Biomarkers in Parkinson’s disease (recent update)

Sharma, Sushil; Moon, Carolyn Seungyoun; Khogali, Azza; Haidous, Ali; Chabenne, Anthony; Ojo, Comfort; Jelebinkov, Miriana; Kurdi, Yousef; Ebadi, Manuchair

doi:10.1016/j.neuint.2013.06.005

Cited by 190 publications

(125 citation statements)

References 182 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Neuronal death in return leads to additional amyloid deposition and eventually vicious cycle repeats itself. Charnoly body has been shown to be a universal marker of neuronal damage (30,31,32). Charnoly body is a pre-apoptotic and early biomarker of compromised mitochondrial bioenergetics and its observation in our animals supports this theory.…”

Section: A Csf+ns Normal Tem Appearance Neuronal Nucleus (N) Dendsupporting

confidence: 60%

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Akyuva

Önal²,

Parlakpınar³

et al. 2018

Period Biol

View full text Add to dashboard Cite

Scope: We investigated the potential beneficial effect of Apocynin (APO) on motor and cognitive functions in experimental Alzheimer's disease (AD). Materials and Methods: Experimental AD was induced in rats by Conclusion: These results indicate that APO can provide neuro-protective effect for motor but not for cognitive performance in experimental AD. INTRODUCTIONI nflammation has been shown to play a vital role in the pathophysiology of the Alzheimer's disease (AD). Microglial cells are responsible for removing the remnants of apoptotic neurons and by doing so they induce an inflammatory response against amyloid plaques via oxidative stress. This theory claims that oxidative stress is the main damaging factor in AD (1, 2, 3). However, antioxidant molecules have not shown to demonstrate significant clinical benefits (2, 4).Recent researches indicate that AD is a brain-specific form of diabetes (5, 6). Hyperglycemia and hyperinsulinemia are correlated with development of 7). Defective insulin signaling, altered levels and/or abnormal activation of components of the insulin signaling pathway, and, more importantly, decreased responsiveness to insulin were found in AD (5,8). In response to infection, trauma or abnormal collection of protein aggregates; TNF-a is produced mainly from microglial cells in the brain. TNF-a levels are increased in AD

show abstract

Section: A Csf+ns Normal Tem Appearance Neuronal Nucleus (N) Dendsupporting

confidence: 60%

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Akyuva

Önal²,

Parlakpınar³

et al. 2018

Period Biol

View full text Add to dashboard Cite

show abstract

“…(1995) demonstrated significantly reduced NAA/Cho ratio in PD patients, and researchers have demonstrated that the level of NAA may reflect the status of neuron function. Specifically, reduced NAA level may represent reduced number of neurons or neuron deficiency, whereas a decreased NAA level reflects severe neurodegeneration and motor impairment (Sharma et al., 2013). Our results agree with previous researches, and the biomarker changes in PD patients in our study could point to neuronal loss or degeneration or neural mitochondrial dysfunction in the PD brain.…”

Section: Discussionmentioning

confidence: 99%

Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease

Guan

Wen

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

IntroductionThe accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy (1H‐MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of 1H‐MRS.Methods PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent 1H‐MRS. Chemical information was obtained for ratios of N‐acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions.ResultsCompared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA/Cr and NAA/Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions (p < .01); NAA/Cr and NAA/Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment (p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA/Cr ratios in the substantia nigra (r = −.32; p = .042).Conclusion NAA/Cr and NAA/Cho ratios may be useful metabolic biomarkers for early diagnosis of PD. Multi‐voxel 1H‐MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD.

show abstract

“…The PPMI study is performing clinical tests on blood, urine and CSF samples; performing neuroimaging to identify better markers of the earlier and accurate diagnosis of PD and its progression [59]. The quantification of dopamine has been extensively used and has traditionally been estimated using spectrophotometry and chromatography.…”

Section: Detection Of Biomarkersmentioning

confidence: 99%

Nanotechnology platforms in Parkinson’s Disease

2015

View full text Add to dashboard Cite

Parkinson's disease (PD) remains a serious concern due to its effects on the quality of life of patients and its socioeconomic burden to society. Present day management of PD has limitations in both diagnosis and treatment. Nanotechnology may provide smart solutions to this problem. The present review highlights the recent advancements in the development of nanotechnology platforms for PD. The review focuses on the use of such platforms in diagnostics, treatments, deep brain stimulation, neurosurgery and other

show abstract

Biomarkers in Parkinson’s disease (recent update)

Cited by 190 publications

References 182 publications

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease

Nanotechnology platforms in Parkinson’s Disease

Contact Info

Product

Resources

About

Biomarkers in Parkinson’s disease (recent update)

Cited by 190 publications

References 182 publications

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Detection and application of neurochemical profile by multiple regional 1H‐MRS in Parkinson's disease

Nanotechnology platforms in Parkinson’s Disease

Contact Info

Product

Resources

About

Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease