Biomarkers in Growth

Raiten, Daniel J.; Raghavan, Ramkripa; Kraemer, Klaus

doi:10.1159/000357572

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…However, many other growth factors and intracellular and extracellular matrix proteins are also critical to regulate cellular activity, providing structural and biochemical support for local tissue growth ( 6 , 7 ). In addition to hormonal and local control, growth and body composition of growing children living in impoverished areas are likely to be affected by a complex interplay between nutrient metabolism and the immune and neurologic systems ( 8 ). Thus, the global discovery mode of plasma proteomics may help to advance our understanding of dynamic structural or regulatory mechanisms of tissue growth associated with nutritional or other environmental exposures.…”

Section: Introductionmentioning

confidence: 99%

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children

et al. 2017

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Background: Malnutrition affects body growth, size, and composition of children. Yet, few functional biomarkers are known to be associated with childhood morphology.Objective: This cross-sectional study examined associations of anthropometric indicators of height, musculature, and fat mass with plasma proteins by using proteomics in a population cohort of school-aged Nepalese children.Methods: Height, weight, midupper arm circumference (MUAC), triceps and subscapular skinfolds, upper arm muscle area (AMA), and arm fat area (AFA) were assessed in 500 children 6–8 y of age. Height-for-age z scores (HAZs), weight-for-age z scores (WAZs), and body mass index–for-age z scores (BAZs) were derived from the WHO growth reference. Relative protein abundance was quantified by using tandem mass spectrometry. Protein-anthropometry associations were evaluated by linear mixed-effects models and identified as having a false discovery rate (q) <5%.Results: Among 982 proteins, 1, 10, 14, and 17 proteins were associated with BAZ, HAZ, MUAC, and AMA, respectively (q < 0.05). Insulin-like growth factor (IGF)-I, 2 IGF-binding proteins, and carnosinase-1 were associated with both HAZ and AMA. Proteins involved in nutrient transport, activation of innate immunity, and bone mineralization were associated with HAZ. Several extracellular matrix proteins were positively associated with AMA alone. The proteomes of MUAC and AMA substantially overlapped, whereas no proteins were associated with AFA or triceps and subscapular skinfolds. Myosin light-chain kinase, possibly reflecting leakage from muscle, was inversely associated with BAZ. The proteome of WAZ was the largest (n = 33) and most comprehensive, including proteins involved in neural development and oxidative stress response, among others.Conclusions: Plasma proteomics confirmed known biomarkers of childhood growth and revealed novel proteins associated with lean mass in chronically undernourished children. Identified proteins may serve as candidates for assessing growth and nutritional status of children in similar undernourished settings. The antenatal micronutrient supplementation trial yielding the study cohort of children was registered at clinicaltrials.gov as NCT00115271.

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Section: Introductionmentioning

confidence: 99%

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children

et al. 2017

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“…The existing method to evaluate child growth is limited to anthropometric measurement which is not always useful to reflect the accurate role of nutritional supplementation in improving growth (Raiten et al, 2013 ). Instruments are expensive, are of poor sensitivity and nonspecific for detecting impaired growth in nutritionally disadvantaged populations.…”

Section: Discussionmentioning

confidence: 99%

“…Measuring children's weight and height have several advantages due to noninvasiveness and available accepted standards. However, these are limited by lower sensitivity and accuracy and unlikely to provide appropriate warning with a decrease in growth unless conducted over a prolonged period of time (Harkare et al, 2021 ; Raiten et al, 2013 ). Indeed, anthropometry alone is insufficient to predict specific differences in patterns between children growing normally and those who are malnourished.…”

Section: Introductionmentioning

confidence: 99%

Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study

Siddiqua

Roy

Akhtar

et al. 2021

Maternal & Child Nutrition

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Little is known about the usefulness of biomarkers to study the influence of prenatal nutrition supplementation in improving child growth. Anthropometry is not always straightforward to understand how nutrition might impact growth, especially in settings with high rates of malnutrition and infections. We examined the effects of prenatal supplementation on growth and growth biomarkers and the relationship between anthropometric measures and growth biomarkers of children at 4.5 and 9 years of age. Children were enrolled from a longitudinal cohort, where mothers were randomized into daily supplementation with either early‐food (≤9 gestation week [GW]) or usual‐food (~20 GW) (608 kcal 6 days/week); they were further randomized to receive 30‐mg or 60‐mg iron with 400‐μg folic acid, or multiple micronutrients (MM) in rural Bangladesh. Anthropometric data were collected from mothers at GW8 and children at 4.5 (n = 640) and 9 years (n = 536). Fasting blood was collected from children at each age. Early‐food supplementation showed reduced stunting and underweight at 4.5 and 9 years age respectively compared to usual‐food. Prenatal supplementations did not have any effect on growth biomarkers except for STAT5b expression which was lower in the early‐food compared to the usual‐food group (β = −0.21; 95 CI% = −0.36, −0.07). Plasma concentrations of 25‐hydroxy vitamin D and calcium were both inversely associated with weight‐for‐age and body mass index‐for‐age Z‐scores at 9 years, particularly in early‐food and MM groups. Although there was minimal effect on child growth by prenatal supplementations, the associations of biomarkers with anthropometric indices were predominantly driven by timing of food or MM supplementations.

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“…34 As the goals of food assistance shift from simply preventing death to promoting well-being, our metrics need to tell us whether food assistance programs are contributing to more productive individuals and societies. 30,35 Three priority areas for food assistance outcome measures beyond z scores were identified during the Evidence Summit: body composition, brain health, and gut health. Examples of each are outlined subsequently; however, further research and testing are needed to determine the most useful and feasible field indicators in each category.…”

Section: Redefine and Expand Indicators Of Nutritional Statusmentioning

confidence: 99%

Advancing Nutrition in the International Food Assistance Agenda: Progress and Future Directions Identified at the 2018 Food Assistance for Nutrition Evidence Summit

et al. 2019

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Background: Global food insecurity persists despite continued international attention, necessitating evidence-based food assistance interventions that adequately address nutritional concerns. In June 2018, the US Agency for International Development’s Office of Food for Peace through the Food Aid Quality Review (FAQR) project sponsored a “Food Assistance for Nutrition Evidence Summit” to share evidence relevant to policy and programmatic decision-making and to identify critical evidence gaps. Objective: This article presents 4 priority areas to advance nutrition in the international food assistance agenda generated through presentations and discussions with the food assistance community at the Evidence Summit. Methods: Priority areas were identified after the Evidence Summit using a combination of FAQR team discussions, review of presentations and official notes, and supporting literature. Results: Key priority areas to advance nutrition in the international food assistance agenda are as follows: (1) increase research funding for food assistance in all contexts, paying particular attention to emergency settings; (2) research and adopt innovative ingredients, technology, and delivery strategies in food assistance products and programs that encourage long-term well-being; (3) redefine and expand indicators of nutritional status to capture contextual information about the outcomes of food assistance interventions; and (4) augment communication and collaboration across the food assistance ecosystem. Conclusions: These priorities are critical in a time of increased humanitarian need and will be key to fostering long-term resilience among vulnerable groups.

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Biomarkers in Growth

Cited by 7 publications

References 19 publications

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children

Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study

Advancing Nutrition in the International Food Assistance Agenda: Progress and Future Directions Identified at the 2018 Food Assistance for Nutrition Evidence Summit

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