Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD)

Das, Saikat; Chowdhuri, Soumeek; Ghosh, Ritwik

doi:10.26735/16586794.2019.011

Cited by 2 publications

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“…of the onset of symptoms, otherwise within 24hrs. after the late was last seen alive (6) . Sudden cardiac deaths due to acute myocardial infarction constitutes a significant percentage of caseload for death investigators, coroners, and forensic pathologist.…”

Section: Introductionmentioning

confidence: 99%

Creditability of Cardiac Biomarkers in Sudden Cardiac Death

Tamara Ablahad Hanna,

Muataz A. AL-Qazzaz

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Natural deaths constitute a significant portion of total deaths cases received for autopsy in general. Cardiovascular system occupies the vast majority of natural death causes. Sudden cardiac death is a catastrophic complication of a number of cardiovascular diseases and affect all ages. Death is mostly unexpected and has a devastating impact on both the surviving family and community. Clinicians use cardiac markers, highly sensitive and specific for detection of myocardial damage to screen living patients for acute myocardial infarction (AMI), however to that point, the utility of those markers for diagnosis of cardiac death in autopsy setting has not been fully established. Materials and Methods: A prospective postmortem case control study was carried out on 103 medico-legal cases referred to the Medico-Legal directorate in Baghdad during 6 months period in 2020. The cases under study were classified in to two groups, those died due to cardiac causes (53) as cases group, and those died due to traumatic causes (50) as control group. Blood samples were collected using disposable syringes to withdraw 3-5ml of blood then immediately centrifuged to separate the serum and stored at -20°C till biochemical analysis for cardiac biomarkers (High sensitive troponin I, MB fraction of Creatin kinase and Lactate dehydrogenase). Results: Males constituted 77% from the total number while females constituted 23%. The mean age of the total study group was 42.57± 15.125 years with a range between 11-72 years. The total number of cases group were 53 case( 77% male and 23% female) with a mean age of 48.89±12.566, compared with 50 cases as controls group from the total number(76%male and 24% female) with mean age of 35.88±14.825. Sensitivity of High sensitive troponin I was 96.2% which was acceptable and it's specificity for diagnosis of sudden cardiac causes of death was 22% which was very low. While Sensitivities of MB fraction of Creatin kinase and Lactate dehydrogenase were 96.2% and 94.3% respectively and their specificities were 6% and 14% respectively. There were no correlations between post mortem interval and all three biochemical parameters levels. Conclusion: High sensitive troponin I, MB fraction of Creatin kinase and Lactate dehydrogenase were not reliable as diagnostic biomarkers for sudden cardiac deaths without gross postmortem and histopathological examination. There were no correlations between the three biomarkers (High sensitive troponin I, MB fraction of Creatin kinase and Lactate dehydrogenase) and the post mortem interval .

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Section: Introductionmentioning

confidence: 99%

Creditability of Cardiac Biomarkers in Sudden Cardiac Death

Tamara Ablahad Hanna,

Muataz A. AL-Qazzaz

2021

Indian Journal of Forensic Medicine & Toxicology

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Gene Expression Pattern Analysis for Forensic Diagnosis of Sudden Cardiac Death

Das

Ghosh

Chowdhuri

2020

ijmsdr

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Diagnosis of Sudden cardiac death (SCD) is challenging for forensic experts. In the current scenario, genetic analysis is rapidly gaining interest in forensic science. Previous studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for forensic diagnostic purposes. This review article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process. Keywords: Sudden Cardiac Death, forensic, gene expression

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Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD)

Cited by 2 publications

References 0 publications

Creditability of Cardiac Biomarkers in Sudden Cardiac Death

Creditability of Cardiac Biomarkers in Sudden Cardiac Death

Gene Expression Pattern Analysis for Forensic Diagnosis of Sudden Cardiac Death

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