Biomarkers in essential hypertension

Pattanaik, Smita

doi:10.1016/b978-0-12-815923-1.00008-0

Cited by 4 publications

(6 citation statements)

References 252 publications

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“…High levels of E‐selectin and ICAM‐1 upregulation have been already associated with hypertension in the general population 28 . Among the huge amount of biomarkers, none seems to be robust enough to replace BP as a biomarker 29 . Some of them, including 24‐h urine catecholamine, plasma renin and aldosterone concentrations or natriuretic peptides, but nitric oxide (NO), were not evaluated in our study.…”

Section: Discussion/conclusionmentioning

confidence: 94%

“…28 Among the huge amount of biomarkers, none seems to be robust enough to replace BP as a biomarker. 29 Some of them, including 24-h urine catecholamine, plasma renin and aldosterone concentrations or natriuretic peptides, but nitric oxide (NO), were not evaluated in our study. It is well known that impaired release of NO, which characterizes vascular endothelial dysfunction, leads to hypertension.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Effect of medium cut‐off and high‐flux hemodialysis membranes on blood pressure assessed by ambulatory blood pressure monitoring

Silva,

Carvalho,

Manfredi

et al. 2024

Artificial Organs

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BackgroundHypertension is one of the most critical risk factors for cardiovascular disease, which is the leading cause of death in hemodialysis (HD) patients. Medium cut‐off (MCO) membrane increases the clearance of medium molecules, which could improve blood pressure (BP) control. This study aimed to compare the effect of MCO and high‐flux hemodialysis membranes on BP assessed by ambulatory blood pressure monitoring (ABPM).MethodsThis is a pre‐established secondary analysis of a 28‐week, randomized, open‐label crossover clinical trial. Patients were randomized to HD with MCO or high‐flux membranes over 12 weeks, followed by a 4‐week washout period, and then switched to the alternate membrane treatment for 12 weeks. ABPM was started before the HD session and ended at least 24 h later in weeks 1, 12, 16, and 28.Results32 patients, 59% male, with a mean age of 52.7 years, and 40% with unknown CKD etiology, were enrolled. The dialysis vintage was 8 years, and more than 70% of the patients had hypertension. Regarding 24‐h BP control, morning diastolic BP showed an increase in the high‐flux compared to stability in the MCO group (interaction effect, p = 0.039). The adjusted ANOVA models showed no significant difference in the morning BP levels between the groups. Considering only the period of the HD session, patients in the MCO, compared to those in the high‐flux membrane group, showed greater BP stability during dialysis, characterized by smaller variation in the pre‐post HD systolic and minimum systolic BP (treatment effect, p = 0.039, and p = 0.023, respectively).ConclusionsMCO membrane seems to have a beneficial effect on morning BP and favors better BP stability during HD sessions.

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Section: Discussion/conclusionmentioning

confidence: 94%

Section: Discussion/conclusionmentioning

confidence: 99%

Effect of medium cut‐off and high‐flux hemodialysis membranes on blood pressure assessed by ambulatory blood pressure monitoring

Silva,

Carvalho,

Manfredi

et al. 2024

Artificial Organs

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“…Furthermore, our discovery analysis identified several proteins associated with both hypertension and SBP that are established biomarkers for hypertension, such as IL-6 (interleukin-6), LOX-1 (lectin-like oxidized lowdensity lipoprotein receptor 1), NT-proBNP, TNF-α (tumor necrosis factor-alpha), and VEGF-A (vascular endothelial growth factor A). 22,23 Additionally, NT-proBNP was successfully validated for its associations with both hypertension and SBP in our validation analysis.…”

Section: Discussionmentioning

confidence: 99%

Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA Age1/Age2 Cohort Studies

Lin,

Petrera,

Hauck

et al. 2024

Hypertension

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BACKGROUND: Hypertension, a complex condition, is primarily defined based on blood pressure readings without involving its pathophysiological mechanisms. We aimed to identify biomarkers through a proteomic approach, thereby enhancing the future definition of hypertension with insights into its molecular mechanisms. METHODS: The discovery analysis included 1560 participants, aged 55 to 74 years at baseline, from the KORA (Cooperative Health Research in the Region of Augsburg) S4/F4/FF4 cohort study, with 3332 observations over a median of 13.4 years of follow-up. Generalized estimating equations were used to estimate the associations of 233 plasma proteins with hypertension and systolic blood pressure (SBP). For validation, proteins significantly associated with hypertension or SBP in discovery analysis were validated in the KORA-Age1/Age2 cohort study (1024 participants, 1810 observations). A 2-sample Mendelian randomization analysis was conducted to infer causalities of validated proteins with SBP. RESULTS: Discovery analysis identified 49 proteins associated with hypertension and 99 associated with SBP. Validation in the KORA-Age1/Age2 study replicated 7 proteins associated with hypertension and 23 associated with SBP. Three proteins, NT-proBNP (N-terminal pro-B-type natriuretic peptide), KIM1 (kidney injury molecule 1), and OPG (osteoprotegerin), consistently showed positive associations with both outcomes. Five proteins demonstrated potential causal associations with SBP in Mendelian randomization analysis, including NT-proBNP and OPG. CONCLUSIONS: We identified and validated 7 hypertension-associated and 23 SBP-associated proteins across 2 cohort studies. KIM1, NT-proBNP, and OPG demonstrated robust associations, and OPG was identified for the first time as associated with blood pressure. For NT-proBNP (protective) and OPG, causal associations with SBP were suggested.

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“…Protein discovery experiments to identify potential biomarker candidates rely on the analysis of a large number of clinical samples. 1,2 These large-scale (N > 100) proteomic studies have the potential to reveal insights into the underlying biochemical mechanisms of various diseases such as cancer, 1 sepsis, 2,3 hypertension, 4,5, and Alzheimer's disease. 6 Quantitative liquid chromatography−tandem mass spectrometry (LC−MS/MS) approaches, in addition to immunoaffinity proximity extension assays (Olink) 7 and aptamer-based assays (SomaScan), 8−10 allow researchers to measure relative protein levels in patient samples.…”

Section: ■ Introductionmentioning

confidence: 99%

Establishing Quality Control Metrics for Large-Scale Plasma Proteomic Sample Preparation

Oliver,

Choi,

Arul

et al. 2024

ACS Meas. Sci. Au

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Large-scale plasma proteomics studies have been transformed due to the multiplexing and automation of sample preparation workflows. However, these workflows can suffer from reproducibility issues, a lack of standardized quality control (QC) metrics, and the assessment of variation before liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis. The incorporation of robust QC metrics in sample preparation workflows ensures better reproducibility, lower assay variation, and better-informed decisions for troubleshooting. Our laboratory conducted a plasma proteomics study of a cohort of patient samples (N = 808) using tandem mass tag (TMT) 16-plex batches (N = 58). The proteomic workflow consisted of protein depletion, protein digestion, TMT labeling, and fractionation. Five QC sample types (QCstd, QCdig, QCpool, QCTMT, and QCBSA) were created to measure the performance of sample preparation prior to the final LC–MS/MS analysis. We measured <10% CV for individual sample preparation steps in the proteomic workflow based on data from various QC sample steps. The establishment of robust measures for QC of sample preparation steps allowed for greater confidence in prepared samples for subsequent LC–MS/MS analysis. This study also provides recommendations for standardized QC metrics that can assist with future large-scale cohort sample preparation workflows.

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Biomarkers in essential hypertension

Cited by 4 publications

References 252 publications

Effect of medium cut‐off and high‐flux hemodialysis membranes on blood pressure assessed by ambulatory blood pressure monitoring

Effect of medium cut‐off and high‐flux hemodialysis membranes on blood pressure assessed by ambulatory blood pressure monitoring

Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA Age1/Age2 Cohort Studies

Establishing Quality Control Metrics for Large-Scale Plasma Proteomic Sample Preparation

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