Biomarkers in connective tissue diseases

Jog, Neelakshi R.; James, Judith A.

doi:10.1016/j.jaci.2017.10.003

Cited by 41 publications

(33 citation statements)

References 122 publications

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“…In RA, ongoing research is focused on finding biomarkers for diagnosis, prognosis, treatment selection, and optimized therapy (Jog & James, ). Two of the most common autoantibodies in patients with RA are rheumatoid factor (RF), directed against the Fc portion of the IgG class of antibodies, and antibodies against citrullinated proteins (ACPAs).…”

Section: Introductionmentioning

confidence: 99%

Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature

et al. 2019

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Objective Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insight into the association between periodontitis and RA. The aim of our study was to review the literature on cytokines in GCF of RA patients including the effect of anti‐rheumatic treatment with biological disease‐modifying anti‐rheumatic drugs (DMARDs) and periodontal treatment on these cytokines. Materials and methods MedLine/PubMed searches with different combinations of keywords “rheumatoid arthritis or RA” and “crevicular fluid or GCF” until June 2019 revealed 64 articles. Ten cross‐sectional observational studies and nine treatment studies fulfilled the inclusion criteria. Results Rheumatoid arthritis patients have increased circulating and GCF levels of pro‐inflammatory cytokines and proteins, despite anti‐rheumatic treatment with biological DMARDs. Presence of periodontitis was accompanied by higher cytokine and protein levels. Treatment of periodontitis resulted in a decrease of these levels. Conclusion Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non‐specific inflammatory burden. Data for a specific relationship are barely present in GCF.

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Section: Introductionmentioning

confidence: 99%

Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature

et al. 2019

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“…69,70 Autoantibodies have been widely used by rheumatologists as a clinical tool in the diagnosis of underlying CTDs. 71 The detection of these autoantibodies often plays a crucial role in the diagnostic workflow of NSIP, as it is the most common form seen in CTD-ILD. Its presence may assist the diagnosis of a previously unrecognized occult CTD and would have major implications for the subsequent management and prognosis of such patients.…”

Section: Diagnostic Testingmentioning

confidence: 99%

Nonspecific Interstitial Pneumonia

Teoh

Corte

2020

Semin Respir Crit Care Med

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Nonspecific interstitial pneumonia (NSIP) is a complex disorder commonly associated with other conditions such as connective tissue diseases (CTDs) and environmental exposures. Although idiopathic NSIP has been recognized as a separate clinical entity, recent studies have suggested that a proportion of these cases have autoimmune features suggestive of underlying CTDs. The diagnosis of NSIP usually carries a better prognosis compared with idiopathic pulmonary fibrosis but has an unpredictable natural history. Its pathogenesis is thought to be an inflammatory-driven process involving multiple pathways, including a genetic predisposition. The lack of specific clinical features often makes the diagnosis of NSIP difficult. The huge variability of radiological and histological features seen in NSIP adds to the complexity of achieving an accurate diagnosis of NSIP and a multidisciplinary approach is often required. There is a lack of consensus on the optimal management strategy of NSIP. Early clarification of the goals of therapy and close monitoring for the progression of disease is important across the spectrum of NSIP irrespective of its etiology. Although immunosuppressive and immunomodulatory agents are commonly used for severe and progressive disease, the therapeutic landscape of NSIP is constantly evolving as the role of newer agents such as antifibrotic therapies is being explored.

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“…Изучение динамики цитокинового профиля имеет важное значение для мониторинга и прогнозирования эффективности терапии ГИБП [35,[382][383][384]. Нами исследованы динамика концентрации аутоантител и цитокинов у больных РА через 12 и 24 нед на фоне терапии препаратом Ацеллбия ® в сопоставлении с препаратом Мабтера ® у 54 пациентов с РА.…”

Section: биоаналоги ритуксимабаunclassified