Biomarkers in Cancer Epidemiology

Boffetta, Paolo; Trichopoulos, D.; Adami, Hans‐Olov; Hunter, David J.

doi:10.1093/oso/9780190676827.003.0005

Cited by 1 publication

(1 citation statement)

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“…MN are a potent tool to study any subgroup of the population at risk. [9] MN are an important marker in the cells of the oral cavity which is obtained from the scrapings of the oral mucosa to know about cellular and nuclear damage. [1] Genetic and chromosomal alterations can be studied in epithelial cells of the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Micronuclei as prognostic marker: A clinicopathologic study

Sherashiya¹,

Nagaraj²,

Hemavathy³

et al. 2016

JMRPS

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Background: Tobacco products attribute to oral cancer. Chronic smoking causes permanent damage to the oral mucosal cells and results in micronuclei (MN) formation. Aims and Objectives: The present study design was to assess the MN number in different locations of the oral cavity and to assess the damaging effects in patients who smoke and those who had left the habit recently. Materials and Methods:Three groups were included in the study. The first group included smokers; the second group included those who recently quit the smoking habit; and the third group included those without habit. Cytosmears were taken and stained with rapid Papanicolaou. MN were observed using a polarized light microscope. Results: Mean values of MN were observed more in the buccal mucosa, followed by lower labial mucosa and floor of the mouth. A significant increase in MN was observed in smokers group, a significant decrease in recently quit habit group and no MN observed in the control group. Conclusion: The genotoxic effects of tobacco smoke cause MN, and the counts can be used as a non-invasive early diagnostic tool. This finding was important in using MN detection in various areas of the mouth and a prognostic indicator to determine smoking cessation.

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Section: Discussionmentioning

confidence: 99%