Biomarkers in alcoholism

Niemelä, Onni

doi:10.1016/j.cca.2006.08.035

Cited by 227 publications

(181 citation statements)

References 116 publications

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“…It should be noted that alcohol intake was positively associated with ␥-GTP and AST activities, supporting the previous findings that alcohol intake is independently and positively associated with circulating ␥-GTP and AST activities (33). This may be because alcohol intake stimulates ROS production and decreases intracellular GSH levels (34,35).…”

Section: Discussionsupporting

confidence: 84%

Associations between Markers of Liver Injury and Cytokine Markers for Insulin Sensitivity and Inflammation in Middle-Aged Japanese Men Not Being Treated for Metabolic Diseases

Mochizuki

Misaki

Miyauchi

et al. 2011

J Nutr Sci Vitaminol

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Summary Elevated circulating alanine aminotransferase (ALT) and ␥ -glutamyltranspeptidase ( ␥ -GTP) activities in healthy and preclinical subjects are associated with increased risk for obesity, diabetes and related complications. In the present study, we examined the associations between these hepatic enzymes and circulating cytokines as markers for insulin sensitivity (adiponectin) and inflammation [interleukin-6 (IL-6)] in middle-aged Japanese men not being treated for metabolic diseases. We conducted a cross-sectional study of 310 Japanese men aged 40-69 y (mean Ϯ SD, 58.8 Ϯ 7.6 y) who were not being treated for metabolic diseases and who participated in health checkups in Japan. We analyzed their lifestyle factors, clinical factors, and plasma adiponectin and IL-6 concentrations. We determined associations between the concentrations of these cytokines and the clinical and lifestyle factors using Spearman's correlation analysis, Jonckheere-Terpstra's test and multiple linear regression. ALT activity was negatively associated with adiponectin ( r ϭϪ 0.302, p Ͻ 0.001) but not with IL-6. ␥ -GTP activity was positively associated with IL-6 ( r ϭ 0.335, p Ͻ 0.001) and negatively associated with adiponectin ( r ϭϪ 0.129, p Ͻ 0.05). Aspartate aminotransferase (AST) activity was positively associated with IL-6 ( r ϭ 0.131, p Ͻ 0.05) and negatively associated with adiponectin ( r ϭϪ 0.125, p Ͻ 0.05). Multiple linear regression analyses showed that adiponectin was independently and negatively associated with ALT activity, while IL-6 was independently and positively associated with ␥ -GTP activity. Adiponectin and IL-6 were not independently associated with AST activity. The results of this study indicate that circulating ALT activity is negatively associated with adiponectin concentration, ␥ -GTP is positively associated with increased IL-6 concentration, and AST is not associated with these cytokines in middle-aged Japanese men not being treated for metabolic diseases.

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Section: Discussionsupporting

confidence: 84%

Associations between Markers of Liver Injury and Cytokine Markers for Insulin Sensitivity and Inflammation in Middle-Aged Japanese Men Not Being Treated for Metabolic Diseases

Mochizuki

Misaki

Miyauchi

et al. 2011

J Nutr Sci Vitaminol

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“…The need for objective methods for revealing alcohol abuse in its early phase has also been widely acknowledged. 4 A variety of liver enzymes assist in the diagnosis of alcohol addiction; including, gamma-glutamyl transferase (GGT), the most sensitive and widely employed marker, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GGT is one of the longest established biochemical tests for excessive alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Study of serum gamma glutamyl transferase as a diagnostic marker in alcoholic hepatitis

gogoi¹

2012

iosrphr

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Abstract--Serum gamma glutamyl transferase (GGT or γ-GT) is a microsomal enzyme, catalyzes the transfer of the gamma-glutamyl moiety of glutathione to various peptide acceptors. It is a reliable diagnostic marker of alcohol ingestion which is one of the most sensitive and most commonly employed biochemical marker of alcohol consumption . This study was carried out with 30 alcoholic hepatitis and 30 normal non-alcoholic control subjects. The aim of this study was to establish the role of serum GGT alone in the diagnosis of alcoholic hepatitis. A significant correlation in the level of serum GGT is observed in alcoholics when compared with the normal subjects. The enzyme activity of GGT in serum is increased in average by 527.31% in the patients with alcoholic hepatitis compared to normal control subjects (p<0.05). Measurement of GGT in serum appears to be a sensitive index with low specificity in the diagnosis of alcoholics with hepatitis when correlated clinically.

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“…Gamma-glutamyltransferase levels [11], mean corpus-cular volume (MCV) [12,13], serum aminotransferases [8] and carbohydrate-defi cient transferring (CDT) are relatively new markers, but remain inadequately studied [14]. Additionally, acetaldehyde adducts, high density lipoprotein, 5-hydroxytryptophol, ethyl glucoronide, phosphatidylethanol, sialic acid, and genetic markers are also subjects of scientifi c efforts to fi nd alcoholism diagnostic methods [5,6]. Alpha amino-N-butyric acid [15], red blood cells acetaldehyde [16], and red blood cell cysteine [17] are also reported as possible alcoholrelated markers.…”

Section: Introductionmentioning

confidence: 99%

“…Alcoholism currently ranks as one of the main threats to the health and safety of people in most Western countries [5,6] A high priority should be given to methods for reducing its prevalence through more effective diagnosis and early intervention. This brings up the need for objective methods for revealing alcohol abuse at an early phase and even assessing the susceptibility to alcoholism.…”

Section: Introductionmentioning

confidence: 99%

Statistical interpretation of medical data of patients with alcohol abuse

et al. 2012

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AbstractAn attempt is made to assess a set of biochemical, kinetic and anthropometric data for patients suffering from alcohol abuse (alcoholics) and healthy patients (non-alcoholics). The main goal is to identify the data set structure, finding groups of similarity among the clinical parameters or among the patients. Multivariate statistical methods (cluster analysis and principal components analysis) were used to assess the data collection. Several significant patterns of related parameters were found to be representative of the role of the liver function, kinetic and anthropometric indicators (conditionally named “liver function factor”, “ethanol metabolism factor”, “body weight factor”, and “acetaldehyde metabolic factor”). An effort is made to connect the role of kinetic parameters for acetaldehyde metabolism with biochemical, ethanol kinetic and anthropometric data in parallel.

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Biomarkers in alcoholism

Cited by 227 publications

References 116 publications

Associations between Markers of Liver Injury and Cytokine Markers for Insulin Sensitivity and Inflammation in Middle-Aged Japanese Men Not Being Treated for Metabolic Diseases

Associations between Markers of Liver Injury and Cytokine Markers for Insulin Sensitivity and Inflammation in Middle-Aged Japanese Men Not Being Treated for Metabolic Diseases

Study of serum gamma glutamyl transferase as a diagnostic marker in alcoholic hepatitis

Statistical interpretation of medical data of patients with alcohol abuse

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