Biomarkers in Acute Kidney Injury

Kulvichit, Win; Kellum, John A.; Srisawat, Nattachai

doi:10.1016/j.ccc.2020.11.012

Cited by 24 publications

(17 citation statements)

References 69 publications

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“…Many other biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), tissue inhibitor of metalloproteinase-2 (TIMP-2) × insulin-like growth factor-binding protein 7 (IGFBP7), and C–C Motif Chemokine Ligand 14 (CCL14) have been studied for diagnostic value in early AKI detection [ 4 ]. However, these biomarkers reflect the cell injury in the setting of AKI, other than the cell function, which can identify a patient’s predisposition and risk of developing AKI.…”

Section: Introductionmentioning

confidence: 99%

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

You

Zheng

et al. 2021

j intensive care

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Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI. Methods We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery. Results The meta-analysis comprising 3148 subjects from 11 studies showed that the uUMOD of the AKI group is significantly lower than the non-AKI group (SMD: − 0.71; 95% confidence interval (CI), − 1.00, − 0.42, P < 0. 001, I2 = 78.8%). Subgroup analysis revealed the difference is also significant in a different age, surgery condition, and assay time but not acute rejection (AR) group, especially in children (SMD: − 1.21, 95% CI: − 1.80, − 0.61; P < 0.001) and patients undergoing surgery (SMD: − 1.03, 95% CI: − 1.75, − 0.30; P < 0.001). Lower uromodulin is associated with higher odds for AKI incidence (odds ratio = 2.47, 95% CI: 1.12, 5.47; P < 0.001, I2 = 89%). Meta-reggression found that age was associated with the SMD of uUMOD. The study outcome was reliably confirmed by the sensitivity analysis. Conclusion The present study suggested a negative association between uUMOD and AKI especially in children and surgical patients.

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Section: Introductionmentioning

confidence: 99%

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

You

Zheng

et al. 2021

j intensive care

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“…Their clinical application could possibly help in differentiating several phenotypes of AKI based on etiology, prognosis, and molecular pathways, which potentially may require different therapies [32]. Excellent reviews summarizing an impressive number of studies covering several aspects of the usefulness and limitations of these biomarkers are available for the interested reader [61][62][63][64][65][66]. Some biomarkers such as neutrophil gelatinaseassociated lipocalin (NGAL), and the cell-cycle biomarkers [metalloproteinase inhibitor 2] × [insulin-like growth factor-binding protein 7] ([TIMP-2] × [IGFBP7]), have been approved by regulatory authorities in some countries.…”

Section: Novel Biomarkers and Their Possible Impact On Definition And...mentioning

confidence: 99%

Reflections on the KDIGO Definition of Acute Kidney Injury and Its Integration in the Concept of Acute Diseases and Disorders and Chronic Kidney Diseases

Lameire

2022

Kidney and Dialysis

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Acute kidney injury (AKI) describes a heterogeneous group of conditions, without specification of their etiology and diagnosed only by indirect markers of glomerular filtration rate (GFR), such as serum creatinine and urine output. Bedside estimation of GFR and detection of structural alterations with novel biomarkers, and stress tests have more recently been developed. These novel findings should probably be included in future AKI definitions. Chronic kidney disease (CKD) is defined by abnormalities in kidney function and structure that persist over >3 months and is classified according to cause, GFR, and albuminuria. Acute kidney disease (AKD) is the term representing patients with abnormalities of function and structure with a duration of ≤3 months that fall outside the definitions of AKI or CKD. Since AKI is by definition also AKD, 2 types of AKD have been proposed, one with and one without AKI. AKD without AKI is common, often undetected, occurs frequently in the outpatient population and shows increased risk of CKD, ESKD and mortality. Alternatively, AKD has also been defined as the period of incomplete recovery following an AKI episode, the latter limited for the duration of 7 days. This contribution discusses the pros and cons of the existence of these 2 definitions of AKD.

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“…Therefore, discovering risk factors of AKI in patients with TBI in the early phase and evaluating the possibility of developing AKI among them are essential to avoid the occurrence of AKI by reducing the usage of nephrotoxic drugs and adjusting treatment strategies. Recently, some research studies explored the value of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and insulin-like growth factor-binding protein-7 (IGFBP-7) in evaluating the risk of AKI and even diagnosing AKI among critically ill patients, such as TBI (3)(4)(5)(6)(7)(8)(9)(10). However, the results of these studies showed different values of these markers in predicting AKI.…”

Section: Introductionmentioning

confidence: 99%

Serum Lactate Level in Early Stage Is Associated With Acute Kidney Injury in Traumatic Brain Injury Patients

Wang

Zhang

et al. 2022

Front. Surg.

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BackgroundAcute kidney injury (AKI) is a common complication in the clinical practice of managing patients with traumatic brain injury (TBI). Avoiding the development of AKI is beneficial for the prognosis of patients with TBI. We designed this study to testify whether serum lactate could be used as a predictive marker of AKI in patients with TBI.Materials and MethodsIn total, 243 patients with TBI admitted to our hospital were included in this study. Univariate and multivariate logistic regression analyses were utilized to analyze the association between lactate and AKI. The receiver operating characteristic (ROC) curves were drawn to verify the predictive value of lactate and the logistic model.ResultsAcute kidney injury group had higher age (p = 0.016), serum creatinine (p < 0.001), lactate (p < 0.001), and lower Glasgow Coma Scale (GCS; p = 0.021) than non-AKI group. Multivariate logistic regression showed that age [odds ratio (OR) = 1.026, p = 0.022], serum creatinine (OR = 1.020, p = 0.010), lactate (OR = 1.227, p = 0.031), fresh frozen plasma (FFP) transfusion (OR = 2.421, p = 0.045), and platelet transfusion (OR = 5.502, p = 0.044) were risk factors of AKI in patients with TBI. The area under the ROC curve (AUC) values of single lactate and predictive model were 0.740 and 0.807, respectively.ConclusionSerum lactate level in the early phase is associated with AKI in patients with TBI. Lactate is valuable for clinicians to evaluate the probability of AKI in patients with TBI.

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Biomarkers in Acute Kidney Injury

Cited by 24 publications

References 69 publications

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

Reflections on the KDIGO Definition of Acute Kidney Injury and Its Integration in the Concept of Acute Diseases and Disorders and Chronic Kidney Diseases

Serum Lactate Level in Early Stage Is Associated With Acute Kidney Injury in Traumatic Brain Injury Patients

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