Biomarkers for Risk Prediction in Acute Decompensated Heart Failure

Velde, A. Rogier van der; Meijers, Wouter C.; Boer, Rudolf A. de

doi:10.1007/s11897-014-0207-7

Cited by 17 publications

(11 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several biomarkers measured during an AHF admission have been reported to independently predict death after discharge, including sST2, galectin-3, copeptin, and mid-regional pro-adrenomedullin etc 1, 30–32 . miRNAs have been found to exist in circulation in a consistent and reproducible manner, making them attractive candidates for biomarker development in AHF patients 23, 24 .…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure

Xiao¹,

Gao²,

Bei³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circulating miR-30d as a prognostic marker of survival in patients with AHF has not been explored. Methods: Patients clinically diagnosed with AHF were enrolled and followed up for 1 year. Quantitative reverse transcription polymerase chain reactions were used to determine serum miR-30d levels. The univariate logistic regression analysis and multivariate logistic regression analysis were used to determine the predictors for all-cause mortality in AHF patients. Kaplan–Meier survival analysis was used to analyze the role of miR-30d in prediction of survival. Results: A total of 96 AHF patients were enrolled and followed up for 1 year. Serum miR-30d was significantly lower in AHF patients who expired in the one year follow-up period compared to those who survived. Univariate logistic regression analysis yielded 18 variables that were associated with all-cause mortality in AHF patients, while the multivariate logistic regression analysis identified 4 variables including heart rate, hemoglobin, serum sodium, and serum miR-30d level associated with mortality. ROC curve analysis showed that hemoglobin, heart rate and serum sodium displayed poor prognostic value for AHF (AUCs not higher than 0.700) compared to miR-30d level (AUC = 0.806). Kaplan–Meier survival analysis confirmed that patients with higher serum miR-30d levels had significantly lower mortality (P=0.001). Conclusion: In conclusion, this study shows evidence for the predictive value of circulating miR-30d as 1-year all-cause mortality in AHF patients. Large multicentre studies are further needed to validate our findings and accelerate the transition to clinical utilization.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure

Xiao¹,

Gao²,

Bei³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Inflammatory markers such as C-reactive protein (CRP) and IL-6 can be used to predict cardiovascular diseases and severity of HF while fibrotic markers such as Gal-3 and syndecan-1 are currently used for risk stratification in HF [137], predicting mortality [138] or readmission [139]. Serial biomarker measurements, after taking biological variability into account, could aid in monitoring the “temporal dynamics” of cardiac pathophysiological processes, thereby offering additive prognostic value [134, 135].…”

Section: Diagnosing and Monitoring Inflammation And Fibrosismentioning

confidence: 99%

From Inflammation to Fibrosis—Molecular and Cellular Mechanisms of Myocardial Tissue Remodelling and Perspectives on Differential Treatment Opportunities

Suthahar

Meijers

Silljé

et al. 2017

Curr Heart Fail Rep

Self Cite

234

159

View full text Add to dashboard Cite

Purpose of ReviewIn this review, we highlight the most important cellular and molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss the interplay between inflammation and fibrosis in various precursors of heart failure (HF) and how such mechanisms can contribute to myocardial tissue remodelling and development of HF.Recent FindingsRecently, many research articles attempt to elucidate different aspects of the interplay between inflammation and fibrosis. Cardiac inflammation and fibrosis are major pathophysiological mechanisms operating in the failing heart, regardless of HF aetiology. Currently, novel therapeutic options are available or are being developed to treat HF and these are discussed in this review.SummaryA progressive disease needs an aggressive management; however, existing therapies against HF are insufficient. There is a dynamic interplay between inflammation and fibrosis in various precursors of HF such as myocardial infarction (MI), myocarditis and hypertension, and also in HF itself. There is an urgent need to identify novel therapeutic targets and develop advanced therapeutic strategies to combat the syndrome of HF. Understanding and describing the elements of the inflammatory and fibrotic pathways are essential, and specific drugs that target these pathways need to be evaluated.

show abstract

“…The circulating biomarker, soluble ST2 (sST2) has been shown to be a powerful independent prognosticator for patients with acute myocardial infarction (AMI)1, 2 as well as acute decompensated3, 4 and chronic5, 6, 7, 8, 9 HF. sST2, a member of the interleukin (IL)‐1 receptor‐like family of proteins, is released in response to myocyte stretch, and functions as a decoy receptor, neutralizing its ligand, IL‐33.…”

Section: Introductionmentioning

confidence: 99%

Soluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community‐Dwelling Population

Parikh

Seliger

Christenson

et al. 2016

JAHA

View full text Add to dashboard Cite

BackgroundSoluble ST2 (sST2), a marker of myocyte stretch and fibrosis, has prognostic value in many cardiovascular diseases. We hypothesized that sST2 levels are associated with incident heart failure (HF), including subtypes of preserved (HFpEF) and reduced (HFrEF) ejection fraction, and cardiovascular death.Methods and ResultsBaseline serum sST2 was measured in 3915 older, community‐dwelling subjects from the Cardiovascular Health Study without prevalent HF. sST2 levels were associated with older age, male sex, black race, traditional cardiovascular risk factors, other biomarkers of inflammation, cardiac stretch, myocardial injury, and fibrosis, and abnormal echocardiographic parameters. In longitudinal analysis, greater sST2 was associated with a higher risk of incident HF and cardiovascular death; however, in multivariate models adjusting for other cardiac risk factors and the cardiac‐specific biomarker, N‐terminal pro–type B natriuretic peptide, these associations were attenuated. In these models, an sST2 level above the US Food and Drug Administration–approved cut‐off value (>35 ng/mL) was significantly associated with incident HF (hazard ratio [HR], 1.20; 95% CI, 1.02–1.43) and cardiovascular death (HR, 1.21; 95% CI, 1.02–1.44), and greater sST2 was continuously associated with cardiovascular death (per 1‐ln increment: HR, 1.24; 95% CI, 1.02–1.50). sST2 was not associated with the HF subtypes of HFpEF and HFrEF in adjusted analysis. Addition of sST2 to existing risk models of HF and cardiovascular death modestly improved discrimination and reclassification into a higher risk.ConclusionsThe predictive value of sST2 for HF of all subtypes and cardiovascular death is modest in an elderly population despite strong cross‐sectional associations with risk factors and underlying cardiac pathology.

show abstract

Biomarkers for Risk Prediction in Acute Decompensated Heart Failure

Cited by 17 publications

References 151 publications

Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure

Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure

From Inflammation to Fibrosis—Molecular and Cellular Mechanisms of Myocardial Tissue Remodelling and Perspectives on Differential Treatment Opportunities

Soluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community‐Dwelling Population

Contact Info

Product

Resources

About