Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study

Li, Xueliang; Sun, Zhaowei; Li, Xiaoxiao; Wang, Qinlei; Chen, Menshou; Zhang, Bingyuan; Feng, Yujie; Han, Bing; Hu, Xiao; Guo, Jingyun; Wang, Maobing; Ma, Kai

doi:10.1097/md.0000000000033314

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Both TBS and AAPR, common indicators in cancer patients, have predictive effects on the prognosis of ICC patients. 7 , 19 Our study combines TBS and AAPR to predict ICC patients' prognosis, exploring their combined role in predicting long‐term outcomes after curative surgery. This is the first study to investigate the role of TBS combined with AAPR in the postoperative prognosis of ICC patients, holding important clinical implications.…”

Section: Discussionmentioning

confidence: 99%

Tumour burden score combined with albumin‐to‐alkaline phosphatase ratio predicts prognosis in patients with intrahepatic cholangiocarcinoma

Wang,

Liu,

Xiang

et al. 2024

J Cellular Molecular Medi

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Tumour morphology (tumour burden score (TBS)) and liver function (albumin‐to‐alkaline phosphatase ratio (AAPR)) have been shown to correlate with outcomes in intrahepatic cholangiocarcinoma (ICC). This study aimed to evaluate the combined predictive effect of TBS and AAPR on survival outcomes in ICC patients. We conducted a retrospective analysis using a multicentre database of ICC patients who underwent curative surgery from 2011 to 2018. The Kaplan–Meier method was employed to examine the relationship between a new index (combining TBS and AAPR) and long‐term outcomes. The predictive efficacy of this index was compared to other conventional indicators. A total of 560 patients were included in the study. Based on TBS and AAPR stratification, patients were classified into three groups. Kaplan–Meier curves demonstrated that 124 patients with low TBS and high AAPR had the best overall survival (OS) and recurrence‐free survival (RFS), while 170 patients with high TBS and low AAPR had the worst outcomes (log‐rank p < 0.001). Multivariate analyses identified the combined index as an independent predictor of OS and RFS. Furthermore, the index showed superior accuracy in predicting OS and RFS compared to other conventional indicators. Collectively, this study demonstrated that the combination of liver function and tumour morphology provides a synergistic effect in evaluating the prognosis of ICC patients. The novel index combining TBS and AAPR effectively stratified postoperative survival outcomes in ICC patients undergoing curative resection.

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Section: Discussionmentioning

confidence: 99%

Tumour burden score combined with albumin‐to‐alkaline phosphatase ratio predicts prognosis in patients with intrahepatic cholangiocarcinoma

Wang,

Liu,

Xiang

et al. 2024

J Cellular Molecular Medi

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Molecular biological role of epithelial splicing regulatory protein 1 in intrahepatic cholangiocarcinoma

Haruna,

Kudo,

Ishino

et al. 2024

Hepatology Research

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AimEpithelial splicing regulatory protein 1 (ESRP1) regulates tumor progression and metastasis through the epithelial‒mesenchymal transition by interacting with zinc finger E‐box binding 1 (ZEB1) and CD44 in cancers. However, the role of ESRP1 in intrahepatic cholangiocarcinoma (iCCA) remains unclear.MethodsThree iCCA cell lines (HuCCT‐1, SSP‐25, and KKU‐100) were analyzed using small interfering RNA to investigate the molecular biological functions of ESRP1 and ZEB1. The association between clinicopathological features and the expression of ESRP1 and ZEB1 in iCCA tissues was analyzed immunohistochemically. Proteomic analysis was performed to identify molecules related to ESRP1 expression.ResultsESRP1 expression was upregulated in HuCCT‐1 and SSP‐25 cells. Cell migration and invasion were enhanced, and the expression of ZEB1 and CD44s (CD44 standard) isoforms were upregulated in the ESRP1 silencing cells. Moreover, ESRP1 silencing increased the expression of N‐cadherin and vimentin, indicating the presence of mesenchymal properties. Conversely, ZEB1 silencing increased the expression of ESRP1 and CD44v (CD44 variant) isoforms. Immunohistochemical analysis revealed that a lower ESRP1‐to‐ZEB1 expression ratio was associated with poor recurrence‐free survival in patients with iCCA. Flotillin 2, a lipid raft marker related to epithelial‒mesenchymal transition, was identified as a protein related to the interactive feedback loop in proteomic analysis.ConclusionsESRP1 suppresses tumor progression in iCCA by interacting with ZEB1 and CD44 to regulate epithelial‒mesenchymal transition.

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Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study

Cited by 2 publications

References 24 publications

Tumour burden score combined with albumin‐to‐alkaline phosphatase ratio predicts prognosis in patients with intrahepatic cholangiocarcinoma

Tumour burden score combined with albumin‐to‐alkaline phosphatase ratio predicts prognosis in patients with intrahepatic cholangiocarcinoma

Molecular biological role of epithelial splicing regulatory protein 1 in intrahepatic cholangiocarcinoma

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