Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers

Ping, Li; Yang, Li; Zhang, Ji; Sang, Yu; Wei, Tong; Hu, Xiaolei; Jia, Guang

doi:10.1097/jom.0000000000000436

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…As SP-D and CC-16 levels seem to reflect different mechanisms of lung damage, we decided to analyze the ratio between these two pneumoproteins ( 37 , 38 ).…”

Section: Resultsmentioning

confidence: 99%

SP-D and CC-16 Pneumoproteins' Kinetics and Their Predictive Role During SARS-CoV-2 Infection

et al. 2022

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BackgroundSurfactant protein D (SP-D) and pulmonary club cell protein 16 (CC-16) are called “pneumoproteins” and are involved in host defense against oxidative stress, inflammation, and viral outbreak. This study aimed to determine the predictive value of these pneumoproteins on the incidence of acute respiratory distress syndrome (ARDS) or death in patients with coronavirus disease-2019 (COVID-19).MethodsThis retrospective study included 87 patients admitted to an emergency department. Blood samples were collected on three time points (days 1, 5, and 14 from hospital admission). SP-D and CC-16 serum levels were determined, and univariate and multivariate analyses considering confounding variables (age, body mass index, tobacco use, dyspnea, hypertension, diabetes mellitus, neutrophil-to-lymphocyte ratio) were performed.ResultsBased on the multivariate analysis, SP-D level on D1 was positively and slightly correlated with subsequent development of ARDS, independent of body mass index, dyspnea, and diabetes mellitus. CC-16 level on D1 was modestly and positively correlated with fatal outcome. A rise in SP-D between D1 and D5 and D1 and D14 had a strong negative association with incidence of ARDS. These associations were independent of tobacco use and neutrophil-to-lymphocyte ratio.ConclusionsOverall, our data reveal that increase in SP-D levels is a good prognostic factor for patients with COVID-19, and that initial CC-16 levels correlated with slightly higher risk of death. SP-D and CC-16 may prove useful to predict outcomes in patients with COVID-19.

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“…As SP-D and CC-16 levels seem to reflect different mechanisms of lung damage, we decided to analyze the ratio between these two pneumoproteins ( 37 , 38 ).…”

Section: Resultsmentioning

confidence: 99%

SP-D and CC-16 Pneumoproteins' Kinetics and Their Predictive Role During SARS-CoV-2 Infection

et al. 2022

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“…Previous studies indicate that circulating CC16 levels are decreased in lung injures caused by agents like tobacco or hexavalent chromium 20, 21. Chronic exposure to toxic agents causes a decline in the overall Clara cells located in terminal and respiratory bronchioles, leading to a relatively low production level of circulating CC16.…”

Section: Discussionmentioning

confidence: 98%

“…Meanwhile, CC16 levels may vary due to differences in sample collection, measurement time points, and methods used in different studies. For example, a previous study of chemical‐induced lung injury in rats has reported decreased serum CC16 levels after an initial transient increase compared to saline solution‐treated control animals 20. Some studies have also revealed that CC16 levels in bronchoalveolar fluid (BALF) differ from blood CC16 levels.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with acute respiratory distress syndrome

Lin

Zhang

Wang

et al. 2017

Clinical Laboratory Analysis

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BackgroundAcute respiratory distress syndrome (ARDS) is a critical condition characterized by bilateral pulmonary infiltrates and severe hypoxemia. This study aimed to evaluate the diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with ARDS.MethodsIn this retrospective observational study, 83 patients with ARDS and 129 non‐ARDS patients on ICU admission were enrolled. The differences in serum CC16 and other laboratory indicators between two groups were analyzed. The sensitivity, specificity, positive and negative predictive values, and accuracy of CC16 as a diagnostic marker on ICU admission were determined by receiver operating characteristic (ROC) curve analysis. The correlation between serum CC16 levels and the severity of ARDS as quantified by PaO2/FiO2 ratio were further assessed. CC16 levels were compared between survivors and non‐survivors. The relationships between CC16 levels and duration of ICU and hospitalization were evaluated.ResultsThe serum CC16 levels in ARDS patients were significantly higher than that in non‐ARDS patients (54.44±19.62 vs 24.13±12.32 ng/mL, P=.001). ROC analysis showed that the sensitivity, specificity, positive predictive value, and negative predictive value were 90.4%, 79.8%, 74.2%, and 92.8%, respectively, when the cut‐off value was set at 33.3 ng/mL. CC16 levels were correlated with the severity of ARDS. The serum CC16 levels were significantly greater in non‐survivors than in survivors from the ARDS group. CC16 levels were associated with ICU stay but not hospital stay.Conclusions CC16 may serve as a diagnostic and stratification marker for ARDS. However, it provided limited prognostic information for ARDS.

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“…However, neither chest X-ray examination nor pulmonary function test is sensitive enough to perceive early health effects. These examinations could be modified by many confounding factors, especially noncompliance of workers and unprofessional determination [ 12 ]. Therefore, it is necessary to investigate proper biomarkers for lung injury among RCFs-exposed workers.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers for Pulmonary Inflammation and Fibrosis and Lung Ventilation Function in Chinese Occupational Refractory Ceramic Fibers-Exposed Workers

Zhu

et al. 2017

IJERPH

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Refractory ceramic fibers (RCFs) can cause adverse health effects on workers’ respiratory system, yet no proper biomarkers have been used to detect early pulmonary injury of RCFs-exposed workers. This study assessed the levels of two biomarkers that are related to respiratory injury in RCFs-exposed workers, and explored their relations with lung function. The exposure levels of total dust and respirable fibers were measured simultaneously in RCFs factories. The levels of TGF-β1 and ceruloplasmin (CP) increased with the RCFs exposure level (p < 0.05), and significantly increased in workers with high exposure level (1.21 ± 0.49 ng/mL, 115.25 ± 32.44 U/L) when compared with the control group (0.99 ± 0.29 ng/mL, 97.90 ± 35.01 U/L) (p < 0.05). The levels of FVC and FEV1 were significantly decreased in RCFs exposure group (p < 0.05). Negative relations were found between the concentrations of CP and FVC (B = −0.423, p = 0.025), or FEV1 (B = −0.494, p = 0.014). The concentration of TGF-β1 (B = 0.103, p = 0.001) and CP (B = 8.027, p = 0.007) were associated with respirable fiber exposure level. Occupational exposure to RCFs can impair lung ventilation function and may have the potential to cause pulmonary inflammation and fibrosis. TGF-β1 and CP might be used as sensitive and noninvasive biomarkers to detect lung injury in occupational RCFs-exposed workers. Respirable fiber concentration can better reflect occupational RCFs exposure and related respiratory injuries.

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Biomarkers for Lung Epithelium Injury in Occupational Hexavalent Chromium-Exposed Workers

Abstract: CC16, as an immunosuppressive protein, and CC16/SP-D can be used as sensitive and noninvasive biomarkers for lung injury. Smoking should be banned in chromium workplaces.

Cited by 17 publications

References 28 publications

SP-D and CC-16 Pneumoproteins' Kinetics and Their Predictive Role During SARS-CoV-2 Infection

SP-D and CC-16 Pneumoproteins' Kinetics and Their Predictive Role During SARS-CoV-2 Infection

Diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with acute respiratory distress syndrome

Biomarkers for Pulmonary Inflammation and Fibrosis and Lung Ventilation Function in Chinese Occupational Refractory Ceramic Fibers-Exposed Workers

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