Biomarkers Association and their Predictive Value in SARS-CoV-2-Infected Hospitalized Patients at a Tertiary Health Care Center

Abstract

This study investigated the association and predictive value of biomarkers in hospitalized patients with SARS-CoV-2 infection. Coronavirus disease (COVID) infection has been linked to a significant hyperinflammatory immune response described as a “cytokine storm,” which results in organ deterioration and damage. Several studies have shown that cytokine levels, notably interleukin 6, can be used as indicators of COVID-19 disease severity. This hospital-based cross-sectional study was conducted in DMIMS Medical College, Sawangi-Meghe, Wardha, from March 2020 to April 2020. The study population was confirmed adult cases of COVID-19 admitted to the hospital during the study period. A positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction or rapid antigen test from a nasopharyngeal swab or other respiratory sample was defined as a confirmed SARS-CoV-2 case. A purposive sampling technique was used and a total of 100 study subjects were enrolled for the study. Our study discovered a link between hematological, coagulation, and inflammatory indicators and infection severity. However, whether these indicators have a mechanistic or causative role in illness progression has to be investigated further.