2023
DOI: 10.3389/fncel.2023.1279046
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Biomarkers associated with the pathogenesis of Alzheimer’s disease

Hui Wang,
Mengli Sun,
Wenhui Li
et al.

Abstract: Alzheimer’s disease (AD) is a progressive degenerative neurological illness with insidious onset. Due to the complexity of the pathogenesis of AD and different pathological changes, the clinical phenotypes of dementia are diverse, and these pathological changes also interact with each other. Therefore, it is of great significance to search for biomarkers that can diagnose these pathological changes to improve the ability to monitor the course of disease and treat the disease. The pathological mechanism hypothe… Show more

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Cited by 5 publications
(2 citation statements)
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References 103 publications
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“…This dysregulation of interleukins and chemokines in the brain causes neurodegeneration through the modulation of several signaling pathways, most notably nuclear factor kappa B (NFκB) [ 4 ]. One of the factors that affect the generation of an inflammatory milieu is the increased production and deposition of Aβ peptides that activate microglia and the subsequent production of cytokines that further enhance Aβ synthesis [ 5 ], a vicious circle that leads to neuronal death and pathological changes in astrocytes that impair Aβ clearance [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…This dysregulation of interleukins and chemokines in the brain causes neurodegeneration through the modulation of several signaling pathways, most notably nuclear factor kappa B (NFκB) [ 4 ]. One of the factors that affect the generation of an inflammatory milieu is the increased production and deposition of Aβ peptides that activate microglia and the subsequent production of cytokines that further enhance Aβ synthesis [ 5 ], a vicious circle that leads to neuronal death and pathological changes in astrocytes that impair Aβ clearance [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…This dysregulation of interleukins and chemokines in the brain causes neurodegeneration through modulation of several signaling pathways, most notably nuclear factor kappa B (NFκB) [4]. One of the factors that affect the generation of an inflammatory milieu is the increased production and deposition of Aβ peptides that activate microglia and the subsequent production of cytokines that further enhance Aβ synthesis [5], a vicious circle that leads to neuronal death and pathological changes in astrocytes that impair Aβ clearance [6].…”
Section: Introductionmentioning
confidence: 99%