Biomarkers and signaling pathways of colorectal cancer stem cells

Abetov, Danysh; Mustapova, Zhanar; Saliev, Timur; Bulanin, Denis

doi:10.1007/s13277-015-3198-4

Cited by 38 publications

(33 citation statements)

References 202 publications

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“…Additional markers such as CD24, CD166 (ALCAM), Oct4, Nanog, Sox2, ALDH1, CD166, CD26, EpCAM are reportedly expressed in colon CSC (Abetov et al, 2015, Wahab et al, 2017. Additional markers such as CD24, CD166 (ALCAM), Oct4, Nanog, Sox2, ALDH1, CD166, CD26, EpCAM are reportedly expressed in colon CSC (Abetov et al, 2015, Wahab et al, 2017.…”

Section: Discussionmentioning

confidence: 99%

Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs)

Sen

Bose

2017

Cell Biology International

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Colorectal cancer is one of the global causes of cancer deaths. Cancer stem cells (CSCs) inside the tumour niche responsible for metastasis and relapses, and hence need to be targeted for cancer therapeutics. Although dietary fibre and lifestyle changes have been recommended as measures for colorectal cancer prevention, no such recommendations are available for using water soluble vitamins as prophylaxis measure for colorectal cancers. High dose of Vitamin C has been proven to selectively kill colon cancer cells having BRAF and KRAS mutations by inducing oxidative stress. In this study, we show for the first time the opposing effects of the low and high dose of Vitamin C and vitamin B3 on colon CSCs isolated from HT-29 and HCT-15 colorectal carcinoma cell lines. At small doses, both of these vitamins exerted a cell proliferative effect only on CSCs, while there was no change in the proliferation status of non-stem cancer cells and wild-type (WT) populations. On the other hand, the death effects induced by high doses of Vitamin C and B3 were of the order of 50-60% and ∼30% on CSCs from HT-29 and HCT15, respectively. Interestingly, the control fibroblast cell line (NIH3T3) was highly refractory all the tested concentrations of Vitamin C and B3, except for the highest dose - 10,000 μg of Vitamin C that induced only 15% of cell death. Hence, these results indicate the future scope of use of therapeutic doses of Vitamin C and B3 especially in patients with advanced colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs)

Sen

Bose

2017

Cell Biology International

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“…Identification of new prognostic biomarkers could be a useful tool in predicting disease development and making personalized treatment plans 48. With the help of TCGA data and other approaches, now studies have located numbers of molecules that might be used as biomarkers 114–117. Besides the expected biomarkers such as SMAD family member 4, APC, tumor protein p53, phosphatidylinositol- 4,5-bisphosphate 3-kinase catalytic subunit alpha, and KRAS proto-oncogene (KRAS) mutations, frequent mutations in AT-rich interaction domain 1A, sex determining region Y-box 9, and FAM123B/WTX were detected in CRC, indicating that these could be used as specific biomarkers for CRC 116…”

Section: Hh Signaling Pathwaymentioning

confidence: 99%

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Zhu

Liu

et al. 2017

OTT

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Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is a complicated and often fatal cancer, and is related to a high disease-related mortality. Around 90% of mortalities are caused by the metastasis of CRC. Current treatment statistics shows a less than 5% 5-year survival for patients with metastatic disease. The development and metastasis of CRC involve multiple factors and mechanisms. The Hedgehog (Hh) signaling plays an important role in embryogenesis and somatic development. Abnormal activation of the Hh pathway has been proven to be related to several types of human cancers. The role of Hh signaling in CRC, however, remains controversial. In this review, we will go through previous literature on the Hh signaling and its functions in the formation, proliferation, and metastasis of CRC. We will also discuss the potential of targeting Hh signaling pathway in the treatment, prognosis, and prevention of CRC.

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“…The Wnt/β-catenin signaling pathway is highly conserved in evolution and found in all metazoan animals [37], and it regulates many life activities and processes [38–40]. Many cases of dysregulation in the pathway have been shown to promote colon tumorigenesis [41].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

Yan

Zhao

et al. 2016

Oncotarget

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Colorectal cancer (CRC) is one of the most common solid tumors worldwide, often associated with inflammation. The microbes in the human intestine have a key role in inflammations and CRC. Chitotriose renders growth advantage to some bacteria, especially some pathogens, and thus has a role in inflammations. The enzyme chitotriosidase, encoded by the CHIT1 gene of the host, may degrade chitotriose with different efficiencies depending on the alleles. We sequenced the CHIT1 gene for 320 Chinese Han CRC patients and 404 normal controls, and focused on variations rs61745299 and rs35920428 within the CHIT1 gene for their possible roles in CRC. Statistical analyses were conducted using Chi-Square Tests as implemented in SPSS (version 19.0). Multiple sequence alignment was conducted using the Vector NTI, and protein expression levels were analyzed by western blotting. The two variations, rs61745299 and rs35920428 within the CDS region of CHIT1 gene, were associated with the risk of CRC (both with P values < 0.001). Western blotting analysis showed that the variations increased the expression levels of the CHIT1 and C-reaction protein genes in the cancer tissue. We conclude that the two variations of CHIT1, rs61745299 and rs35920428, increase expression of the gene and are associated with CRC in Chinese Han populations.

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Biomarkers and signaling pathways of colorectal cancer stem cells

Cited by 38 publications

References 202 publications

Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs)

Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs)

Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

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