Biomarkers and predicting acute kidney injury

Luft, Friedrich C.

doi:10.1111/apha.13479

Cited by 59 publications

(37 citation statements)

References 42 publications

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“… 16 25 45 – 49 To prevent asymptomatic acute kidney injury that may result from COVID-19 infection, we recommend assessment of traditional urine biomarkers such as the glomerular filtration rate of the kidney, creatinine, albumin urea, cystatin C, beta-trace protein, beta-2 microglobulin and fatty acid-binding proteins. 50 51 For a better understanding, biomarkers are presented in table 1 . During the first month of practice, tracking the evolution of kidney and liver biomarkers could be of great help to understand the consequences of the viral infection and prevent a putative worsening due to a too rapid and/or too high energy expenditure.…”

Section: Multiorgan Threat and Global Assessment For Infected Athletementioning

confidence: 99%

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Guivier-Curien

Grélot

Vanbiervielt

et al. 2020

BMJ Open Sport Exerc Med

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COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and headache. In more severe cases, dyspnoea, hypoxaemia, respiratory failure, shock and multiorgan failure occur. This appears to be a self-limiting phenomenon related to individuals with coexisting medical conditions, such as hypertension, diabetes and cardiovascular disorders. Nevertheless, cases have been reported in professional soccer players in extremely good fitness condition, demonstrating that athletes are not spared by the disease. Despite COVID-19 clinical manifestations are mainly respiratory, major cardiac complications are being reported, leading to acute myocarditis. One difficulty is that symptoms of COVID-19 vary among individuals, with athletes being affected with no apparent sign of the disease. This could be a real danger for amateur or professional athletes when returning to their usual training and thus to play. Another threat is that the lock-down policies did not allow most athletes to follow their usual training routines. There is thus a need for a careful approach by the sports medicine community to ensure safety of all athletes before they return to sport. Here, we propose evaluation guidelines of fitness and health of athletes to (1) reduce any lethal risk of practice, especially myocarditis and sudden cardiac death; (2) evaluate the combined consequences of the disease and detraining on the physical abilities and biological profile of athletes; and (3) monitor postinfection fatigue symptoms.

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Section: Multiorgan Threat and Global Assessment For Infected Athletementioning

confidence: 99%

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Guivier-Curien

Grélot

Vanbiervielt

et al. 2020

BMJ Open Sport Exerc Med

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“…The actual criteria used to define AKI and its stages are not entirely accepted by all researchers and clinicians, who consider SCr and urine output more accurate markers of kidney dysfunction than AKI; consequently, both parameters are not ideal markers of AKI [47]. Over the last few years, many urine or blood biomarkers of AKI have been proposed as adjunct diagnostics to SCr and urinary output to improve the early detection, differential diagnosis, and prognostic assessment of AKI [48,49]. The following are among the novel biomarkers of AKI:…”

Section: General Aspects Of Acute Kidney Injurymentioning

confidence: 99%

“…Kidney injury molecule-1 (KIM-1): lesions in proximal tubule cells [44,49,52]. Interleukin-18 (IL-18): lesions in collecting duct and tubular epithelial cells [48,49]. Liver-type fatty acid-binding protein (L-FABP): lesions in proximal tubule cells [49].…”

Section: General Aspects Of Acute Kidney Injurymentioning

confidence: 99%

“…Liver-type fatty acid-binding protein (L-FABP): lesions in proximal tubule cells [49]. Calprotectin (S100A8/9): lesions in collecting ducts and filtrating immune cells [48,50]. In general, the mechanisms involved in the pathophysiology of AKI are attributed to renal damage caused by ischemic process, oxidative stress, and inflammation [30,53].…”

Section: General Aspects Of Acute Kidney Injurymentioning

confidence: 99%

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Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

Diniz¹,

Souza

Duarte

et al. 2020

Molecules

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The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.

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“…Studies on AKI have focused on novel injury biomarkers, contributing to earlier diagnosis of AKI. Although many urinary biomarkers have been reported in adults and children [1,7,8], these early biomarkers have not been widely accepted and adopted to clinical practice, especially in children. Strong evidence is still needed to con rm that early urinary biomarkers of AKI have bene cial effects on the clinical outcomes in a general pediatric intensive care unit (PICU) population.…”

Section: Introductionmentioning

confidence: 99%

Urinary CXCL10 is Associated with Acute Kidney Injury and Sepsis, and Predicts Mortality in Critically Ill Children

Huang¹,

Zhou²,

Wang³

et al. 2020

Preprint

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Background: Acute kidney injury (AKI) biomarkers are often susceptible to confounding factors, limiting their utility as a specific biomarker, in the prediction of AKI, especially in heterogeneous population. The urinary CXC motif chemokine 10 (uCXCL10), as an inflammatory mediator, has been proposed to be a biomarker for AKI in a specific setting. Whether uCXCL10 is associated with AKI and predicts AKI in critically ill patients remains unclear. The aims of the study were to investigate clinical variables potentially associated with uCXCL10 levels and determine the associations of uCXCL10 with AKI, sepsis and PICU mortality in critically ill children, as well as its predictive values of aforementioned issues. Methods: Urinary CXCL10 levels were serially measured in a heterogeneous group of children during the first week after pediatric intensive care unit (PICU) admission. AKI diagnosis was based on the criteria of Kidney Disease: Improving Global Outcomes with serum creatinine and urine output. Sepsis was diagnosed according to surviving sepsis campaign international guidelines for children. Mortality was defined as all-cause death occurring during the PICU stay.Results: Among 342 critically ill children, 52 (15.2%) developed AKI during the first week after PICU admission, and 132 (38.6%) were diagnosed as sepsis and 30 (12.3%) died during PICU stay. Both the initial and peak values of uCXCL10 remained independently associated with AKI with adjusted odds ratios (AORs) of 1.791 (P = 0.010) and 2.002 (P = 0.002), sepsis with AORs of 1.679 (P = 0.003) and 1.752 (P = 0.002), septic AKI with AORs of 3.281 (P <0.001) and 3.172 (P <0.001), and PICU mortality with AORs of 2.779 (P = 0.001) and 3.965 (P <0.001), respectively. The AUCs of the initial uCXCL10 for predicting AKI, sepsis, septic AKI, and PICU mortality were 0.63 (0.53-0.72), 0.62 (0.56-0.68), 0.75 (0.64-0.87), and 0.77 (0.68-0.86), respectively. The AUCs for prediction by using peak uCXCL10 were as follows: AKI 0.65 (0.56-0.75), sepsis 0.63 (0.57-0.69), septic AKI 0.76 (0.65-0.87), and PICU mortality 0.84 (0.76-0.91).Conclusions: Urinary CXCL10 is independently associated with AKI and sepsis, and may be a potential indicator of septic AKI and PICU mortality in critically ill children.

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Biomarkers and predicting acute kidney injury

Cited by 59 publications

References 42 publications

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

Urinary CXCL10 is Associated with Acute Kidney Injury and Sepsis, and Predicts Mortality in Critically Ill Children

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