Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

Qin, Qixiong; Cheng, Xue-Min; LiZhi, Lu; Wei, Yunfei; Wang, Dacheng; Li, Haihua; Li, Guohui; Liang, Hongbin; Li, Shengyu; Chen, Li; Liang, Zhijian

doi:10.3748/wjg.v24.i43.4950

Cited by 11 publications

(14 citation statements)

References 36 publications

(48 reference statements)

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“…Similar results were found in our previous studies. 7,9 Increased levels of serum CA125, a type of mucin that is secreted by the cancer cell, were found to be related to hypercoagulability ischemic stroke in patients with cancer. 25 Moreover, autopsy experiments confirmed that there were mucin components that were secreted by cancer cells in the blood vessels, and they were thromboembolic in patients with cancer and ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies showed that the occurrence of CRIS was related to independent risk factors that were derived from serum, and the independent risk factors for CRIS are heterogeneous because they have different pathological types. [7][8][9] It was suggested that the characteristics of specific pathological types of CRIS risk factors may identify CRIS and may even predict its occurrence. Bladder cancer is the tenth most frequent cancer worldwide and the most common urinary tract malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Independent risk factors and the potential predictors of bladder cancer-related ischemic stroke

Quan

Qin

et al. 2020

J Int Med Res

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Objective To investigate the independent risk factors and potential predictors of bladder cancer-related ischemic stroke (BCRIS). Methods This was a multi-center retrospective study including patients with active bladder cancer and acute ischemic stroke without traditional stroke risk factors (BCRIS group), and sex- and age-matched patients with active bladder cancer alone (control group). Data were collected between January 2006 and December 2018. Uni- and multivariate analyses were performed to identify independent risk factors for BCRIS. The predictive performance of these risk factors was assessed using receiver operating characteristic (ROC) curves. Results Records were retrospectively reviewed from 60 BCRIS patients and 120 bladder cancer controls. Univariate analysis revealed that serum D-dimer and carcinoembryonic antigen (CEA) levels and the platelet and neutrophil counts were significantly higher in BCRIS patients compared with controls. Multivariate analysis identified the three above-mentioned variables as independent risk factors for BCRIS. The product of all three factors gave the largest area under the ROC curve. Conclusions Elevated serum D-dimer and CEA levels and increased platelet count were independent risk factors for BCRIS, and the cut-off value based on the product of the three independent risk factors (≥2,640,745.29) could serve as a potential predictor of BCRIS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Independent risk factors and the potential predictors of bladder cancer-related ischemic stroke

Quan

Qin

et al. 2020

J Int Med Res

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“…This was a retrospective study of patients with ECIS from January 2011 to December 2020 at The First Affiliated Hospital of Guangxi Medical University, The Second Affiliated Hospital of Guangxi Medical University, The Ninth Affiliated Hospital of Guangxi Medical University, Fusui County People's Hospital, Wuzhou Red Cross Hospital, Cenxi People's Hospital and The Wuming Hospital of Guangxi Medical University. Based on a previous definition of cancer-related ischemic stroke, [12][13][14] we defined ECIS as acute ischemic stroke in patients with active EC and without conventional stroke risk factors. In the present study, we defined the conventional stroke risk factors as the presence of hypertension, diabetes, hyperlipidemia, atrial fibrillation, valvular heart disease, and cerebral artery stenosis.…”

Section: Patient Selectionmentioning

confidence: 99%

“…11 Moreover, our previous studies have found that every confirmed cancer-related ischemic stroke has its own unique clinical characteristics and risk factors, suggesting that targeting a certain type of cancer-related ischemic stroke will be more conducive to discovering the clinical characteristics and pathogenesis of cancer-related ischemic stroke. [12][13][14] For example, colorectal cancer-related ischemic stroke was associated with elevated CEA and neutrophils, 12 kidney cancerrelated stroke was associated with elevated plasma D-dimer, CA125 and CEA levels, and increased urine protein levels, 13 and breast cancer-related ischemic stroke was associated with endocrine therapy, elevated plasma D-dimer and CA153 levels. 14 Esophageal cancer (EC) is one of the most common digestive tract tumors worldwide.…”

Section: Introductionmentioning

confidence: 99%

The Index of Esophageal Cancer Related Ischemic Stroke: A Retrospective Patient Control Study

Liu¹,

LiZhi²,

Cheng³

et al. 2022

NDT

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To investigate independent risk factors for esophageal cancer-related ischemic stroke (ECIS) and to use them to develop an index of ECIS to help clinicians identify patients at high risk for ECIS or to identify ECIS from other types of ischemic stroke. Methods: We retrospectively enrolled active esophageal cancer (EC) patients with acute ischemic stroke (ECIS group) and patients with active EC without ischemic stroke (EC group), age-and sex-matched with ECIS patients, at seven centers from January 2011 to December 2020. Clinical data and laboratory and imaging findings were collected. Univariate and multivariate analyses were performed to analyze the independent risk factors for ECIS. Optimal cutoffs for sensitivities and specificities were obtained by Youden's J statistic following a receiver operator characteristic (ROC) analysis of each risk factor and the product of the risk factors. Results: A total of 91 ECIS patients and 91 EC patients were included. Elevated levels of carcinoembryonic antigen (CEA) [odds ratio (OR) = 0.105, 95% confidence interval (CI): 1.051-1.174, P < 0.001], D-dimer (DD) (OR = 0.003, 95% CI: 1.002-1.004, P < 0.001), and neutrophil count (OR = 0.857, 95% CI: 1.628-3.407, P < 0.001) were independent risk factors for ECIS. The area under the curve (AUC) of each independent risk factor and the product of the three independent risk factors were calculated by a receiver operator characteristic (ROC) curve, and the cutoff value from the largest AUC was called the ECIS index. Conclusion: It was suggested that elevated plasma DD and CEA levels and increased neutrophils in EC patients may altogether contribute to the development of ECIS. The index of ECIS may facilitate clinicians to identify patients at high risk for ECIS or to identify ECIS from other etiologic types of ischemic stroke.

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“…Some studies in various countries have found that the incidence of AIS is significantly higher in cancer patients than in noncancer patients [1][2][3][4][5][6][7], but the specific causes are not clear. Most of the authors suggested in published articles that the biological indicators we should focus on cancer-associated AIS patients were D-dimers and carbohydrate tumor markers [8][9][10][11][12]. However, the research concerning clinical characteristics, risk factors, pathogenesis, and survival situation of cancerassociated AIS patients were rare.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke

Lin

et al. 2019

BioMed Research International

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Objective. To research the clinical characteristics and risk factors of lung cancer-associated acute ischemic stroke (LCA-AIS). Methods. Patients diagnosed with LCA-AIS, simple lung cancer, and simple AIS were enrolled. The primary information, laboratory results, tumor histopathology, neurological deficits, and survival time of the patients were collected and analyzed. Results. (1) In the LCA-AIS group, the pathology of 69.56% patients were adenocarcinoma, and the proportion of poorly differentiated patients was significantly more than that in moderately differentiated or highly differentiated. The number of stage IV lung cancer patients in the LCA-AIS group was significantly more common than in other stages. (2) 56.52% of patients with lung cancer were diagnosed before AIS, and the peak of AIS attack was 1–6 months after the diagnosis of lung cancer. (3) The independent risk factors of LCA-AIS were CYFRA-211 (OR 1.070; 95% confidence interval 1.005, 1.139; p=0.035), TT (OR 1.275; 95% confidence interval 1.089, 1.493; p=0.003), and Hct (OR 0.878; 95% confidence interval 0.779, 0.990; p=0.034), making ROC curve, suggesting the area under the curve is 0.871. (4) The neurological deficit of patients in the LCA-AIS group was similar to the simple AIS group and could not be identified by the severity of neurological deficits. (5) The median survival time of LCA-AIS group patients was five months (95% confidence interval 3.796, 6.204). There were statistical differences in survival time between LCA-AIS group and simple AIS group patients (p<0.001).Conclusions. The interaction between lung cancer and AIS may shorten patients’ life expectancy and worsen their quality of life.

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Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

Cited by 11 publications

References 36 publications

Independent risk factors and the potential predictors of bladder cancer-related ischemic stroke

Independent risk factors and the potential predictors of bladder cancer-related ischemic stroke

The Index of Esophageal Cancer Related Ischemic Stroke: A Retrospective Patient Control Study

Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke

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