Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Hooke, Mary C.; Mathiason, Michelle A.; Kunin‐Batson, Alicia; Blommer, Audrey; Hutter, Jessica; Mitby, Pauline; Moore, Ida M.; Whitman, Susan A.; Taylor, Olga A.; Scheurer, Michael E.; Hockenberry, Marilyn J.

doi:10.1188/21.onf.623-633

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Particularly, higher levels of certain CSF biomarkers (e.g., total tau and amyloid-β) associated with neuronal damage have been shown to act as an accurate predictor of progression from mild cognitive impairment to Alzheimer’s disease [ 32 ]. In cancer, a study indicated greater amounts of the CSF biomarker F2-isoprostane in children with acute lymphocytic leukemia (ALL), correlated with poorer attention and inhibitory control [ 33 ]. It does have to be kept in mind, however, that access to the CSF samples in these patients was made feasible by intrathecal chemotherapy, a relatively common treatment administered for ALL, indicating the limited utility of lumbar puncture for routine CRCI diagnosis in those not receiving intrathecal treatment.…”

Section: Discussionmentioning

confidence: 99%

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Chan

Acharya

et al. 2023

Cancers

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Background: We examined the research attitudes and willingness to participate in clinical research among cancer survivors with varying degrees of cognitive function. Methods: This is a secondary analysis of data collected through the University of California Irvine Consent-to-Contact registry. Cancer survivors completed the Cognitive Function Instrument (CFI), the Research Attitudes Questionnaire (RAQ), and willingness to participate (WTP) in certain research procedures. Perceived cognitive impairment (CI) was defined as the worst 20% CFI scores. Results: Here, 265 CI and 909 cognitively non-impaired (CNI) participants’ data were analyzed. Mean age and sex distribution were similar, with fewer non-Hispanic Whites and education years among CI participants. More CI participants self-reported past diagnoses of Alzheimer’s disease, mild cognitive impairment, stroke, depression, post-traumatic stress disorder, and alcohol abuse (all p < 0.05). CI participants were significantly more interested in studies investigating approved medications (92% vs. 87%, p = 0.030), lumbar puncture (47% vs. 38%, p = 0.027), and autopsy (78% vs. 69%, p = 0.022). After removing survivors with co-existing neuropsychiatric conditions, interest in autopsy studies remained statistically higher among CI (79% vs. 69%, p = 0.022). Conclusions: Participants with cancer and CI are open to research procedures and interventions that are traditionally less utilized, which may facilitate the discovery of the pathogenesis and interventions for cancer-related cognitive impairment (CRCI).

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Section: Discussionmentioning

confidence: 99%

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Chan

Acharya

et al. 2023

Cancers

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“…This study was a companion to a larger primary study that measured symptoms during the first year of ALL treatment (Hockenberry et al, 2017, Hockenberry et al, 2019. As the companion study, some of the results are now published and report how symptoms and biomarkers changed during maintenance therapy after being measured in the first cycle of maintenance (in the primary study) and the last cycle of ALL maintenance treatment (companion study; Hooke, Mathiason et al, 2021;Hooke et al, 2022). To be consistent, the self-report measures used in the primary study were repeated in this companion study.…”

Section: Study Measurement Proceduresmentioning

confidence: 99%

Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy

Hooke

Salisbury

Mathiason

et al. 2023

Journal of Pediatric Hematology/Oncology Nursing

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Background: Symptoms in children with acute lymphocytic leukemia (ALL) change over the trajectory of treatment but little is known about their symptoms as treatment ends. Physical activity may help decrease symptom distress and is vital for ongoing development. The role of biomarkers in symptom science is emerging. The purpose of the study was to explore relationships between self-report of symptoms and physical activity, actigraphy measures, and cerebrospinal fluid (CSF) biomarkers. Methods: Participants were children who were ages 3 to 18 years at the time of ALL diagnosis and were now in the last 12-week cycle of ALL maintenance. Self-reports of fatigue, sleep disturbance, depressive symptoms, and physical activity were completed by participants and parents of younger children. Participants wore a wrist actigraph continuously for the 7 days before other measurements. F2-isoprostanes and interleukin-8 were evaluated in CSF samples. Results: Among the 15 participants, self-report of symptoms and physical activity indicated levels similar to healthy peers. F2-isoprostane had a strong positive correlation with fatigue levels and with depressive symptoms. Fatigue, sleep disturbance, and depressive symptoms positively correlated with each other. Actigraph measures showed children met the CDC guidelines for 60 min of daily moderate to vigorous activity; sleep time was slightly less than healthy norms. Discussion: During maintenance therapy, most children return to healthy norms in symptom burden and physical activity. F2-isoprostane in the CSF is a biomarker for fatigue and depressive symptoms. Children who had persistent symptoms experienced them as a cluster, which confirms previous symptom cluster research.

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Section: What's This Got To Do With Nursing? the Intersection Between...mentioning

confidence: 99%

“…In this model, nurse scientists initiate investigations involving underlying pathophysiological mechanisms that facilitate widespread health policy changes to promote population health (Casavant, 2020). Many nurse researchers are placing greater focus on the biologic processes surrounding diseases at the cellular and molecular levels through the identification of biomarkers (Dekker et al, 2017; Ferranti et al, 2017; Hooke et al, 2021). Furthermore, nurses are utilizing biomarkers to accurately identify a person's health risk, evaluate the biological mechanisms that attribute to adverse clinical outcomes, and develop interventions that optimize health in various patient populations (Ielapi et al, 2020).…”

mentioning

confidence: 99%

What's this got to do with nursing? The intersection between nursing and basic science

Mahoney

2022

Journal of Advanced Nursing

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Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Cited by 4 publications

References 34 publications

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment

Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy

What's this got to do with nursing? The intersection between nursing and basic science

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