Biomarker role of maternal soluble human leukocyte antigen G in pre‐eclampsia: A meta‐analysis
Abhinav Bhattarai,
Sangam Shah,
Krishna Dahal
et al.
Abstract:IntroductionHuman leukocyte antigen‐G (HLA‐G) is a non‐classical class I HLA molecule shown to regulate the immunomodulation of maternal immune cells to prevent fetal tissue destruction. Low levels of freely circulating maternal soluble HLA‐G (sHLA‐G) have been observed in pre‐eclampsia, however, no pooled evidence exists. This meta‐analysis aimed to generate pooled findings on the association of sHLA‐G levels with pre‐eclampsia and is the first study to perform a trimester‐wise comparison of the levels of sHL… Show more
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