Biomarker responses of earthworms (Eisenia fetida) exposured to phenanthrene and pyrene both singly and combined in microcosms

Wu, Shijin; Zhang, Huaxing; Zhao, Shiliang; Wang, Junliang; Li, Huilong; Chen, Jianmeng

doi:10.1016/j.chemosphere.2011.11.055

Cited by 67 publications

(15 citation statements)

References 30 publications

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“…Several proteins produced multiple spots, which was most likely caused by post‐translational modifications (PTMs). In most cases, the shifts in position were horizontal, suggesting that the modifications only affected the pI without changes in molecular mass …”

Section: Discussionmentioning

confidence: 99%

Effects of novel brominated flame retardant TBBPA on human airway epithelial cell (A549) in vitro and proteome profiling

et al. 2018

Environmental Toxicology

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The cellular toxicity response of human airway epithelial cells (A549) to tetrabromobisphenol (TBBPA) was assessed in vitro. Cell viability, levels of intracellular reactive oxygen species (ROS), lipid peroxidation (MDA), and caspase-3 activity were determined after A549 treated with varying concentrations of TBBPA. A comparative proteomic analysis was performed in cells treated with different concentrations of TBBPA (0, 10, and 40 μg/mL). Two-way anova analysis showed that cell viability was significantly decreased after treatment by TBBPA with a concentration of 16 μg/mL for 48 hr, however, the caspase-3 activities, ROS generation, and MDA content increased. Ultrastructural observation revealed that the cell was morphological damaged after exposure to 64 μg/mL TBBPA, with mitochondria seriously injured and the smooth endoplasmic reticulum dilated. There was a good correlation between ROS generation and mitochondrial dysfunction. Seventeen differentially expressed proteins involved in various biological processes were identified. These findings provide a basis for understanding the mechanisms of cell dysfunction and perturbation of antioxidant status induced by additive flame retardant on airway epithelial cells.

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Section: Discussionmentioning

confidence: 99%

Effects of novel brominated flame retardant TBBPA on human airway epithelial cell (A549) in vitro and proteome profiling

et al. 2018

Environmental Toxicology

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“…Biomass changes could be a good indicator of chemical stress and link chemical effects to energy dynamics and, ultimately, to growth inhibition (Shi et al 2007;Wu et al 2012). Previous reports indicated that some monomers of PBDEs significantly inhibited the growth of the earthworm (E. fetida).…”

Section: Discussionmentioning

confidence: 99%

Growth Inhibition and Altered Gene Transcript Levels in Earthworms (Eisenia fetida) Exposed to 2,2′,4,4′-Tetrabromodiphenyl Ether

Shi

Lü

et al. 2015

Arch Environ Contam Toxicol

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“…CAT catalyzes the conversion of H 2 O 2 to water and oxygen and in this way removes H 2 O 2 , providing protection against oxidative damage to the cell. Exposure to chemicals may lead to a decrease in CAT activity and cellular lesions (Wu et al, 2012). Our study indicated that CAT activity was inhibited in earthworms exposed to DBP concentrations of 5-50 mg kg À 1 after 21-28 d of exposure.…”

Section: Discussionmentioning

confidence: 84%

Evaluation of DNA damage and antioxidant system induced by di-n-butyl phthalates exposure in earthworms (Eisenia fetida)

Liu

et al. 2015

Ecotoxicology and Environmental Safety

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Biomarker responses of earthworms (Eisenia fetida) exposured to phenanthrene and pyrene both singly and combined in microcosms

Cited by 67 publications

References 30 publications

Effects of novel brominated flame retardant TBBPA on human airway epithelial cell (A549) in vitro and proteome profiling

Effects of novel brominated flame retardant TBBPA on human airway epithelial cell (A549) in vitro and proteome profiling

Growth Inhibition and Altered Gene Transcript Levels in Earthworms (Eisenia fetida) Exposed to 2,2′,4,4′-Tetrabromodiphenyl Ether

Evaluation of DNA damage and antioxidant system induced by di-n-butyl phthalates exposure in earthworms (Eisenia fetida)

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