Biomarker Research Approach to the Pathogenesis of Ossification of the Spinal Ligament: A Review

Kawaguchi, Yoshiharu

doi:10.22603/ssrr.2021-0229

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…SDD related to bone metabolism includes OVF and hyperostotic diseases [i.e., ossification of posterior longitudinal ligament (OPLL) and diffuse idiopathic skeletal hyperostosis (DISH)] ( Figure 3 ). Osteoporosis and hyperostotic diseases have an immune-inflammatory mechanism involved in their pathogenesis ( Zaiss et al, 2019 ; Mader et al, 2021 ; Kawaguchi, 2022 ). Bone is an organ that depends on the dynamic balance between osteoblasts and osteoclasts to maintain normal function.…”

Section: Gut-spine Axismentioning

confidence: 99%

“…Regarding osteoimmunology, GM dysbiosis has been reported to contribute to osteoporosis ( Wang et al, 2017 ; Ibáñez et al, 2019 ; Ling et al, 2021 ) but may also affect hyperostosis diseases. Hyperostotic diseases such as OPLL and DISH exhibit a strong association with obesity, type 2 diabetes mellitus, and the complications of metabolic syndrome, which are characterized by systemic low-grade inflammation related to aging ( Mader et al, 2021 ; Kawaguchi, 2022 ). In addition, OPLL has been reported to be associated with leptin and chronic inflammation ( Kawaguchi, 2022 ).…”

Section: Gut-spine Axismentioning

confidence: 99%

“…Hyperostotic diseases such as OPLL and DISH exhibit a strong association with obesity, type 2 diabetes mellitus, and the complications of metabolic syndrome, which are characterized by systemic low-grade inflammation related to aging ( Mader et al, 2021 ; Kawaguchi, 2022 ). In addition, OPLL has been reported to be associated with leptin and chronic inflammation ( Kawaguchi, 2022 ). As mentioned, GM dysbiosis affects bone metabolism in association with low levels of chronic inflammation-related diseases and the neurotransmitter leptin, suggesting that it could be a pathological factor not only in osteoporosis but also in hyperostotic diseases such as OPLL.…”

Section: Gut-spine Axismentioning

confidence: 99%

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Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases

Morimoto,

Kobayashi,

Kakiuchi

et al. 2023

Front. Microbiol.

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As society ages, the number of patients with spinal degenerative diseases (SDD) is increasing, posing a major socioeconomic problem for patients and their families. SDD refers to a generic term for degenerative diseases of spinal structures, including osteoporosis (bone), facet osteoarthritis (joint), intervertebral disk degeneration (disk), lumbar spinal canal stenosis (yellow ligament), and spinal sarcopenia (muscle). We propose the term “gut-spine axis” for the first time, given the influence of gut microbiota (GM) on the metabolic, immune, and endocrine environment in hosts through various potential mechanisms. A close cross-talk is noted between the aforementioned spinal components and degenerative diseases. This review outlines the nature and role of GM, highlighting GM abnormalities associated with the degeneration of spinal components. It also summarizes the evidence linking GM to various SDD. The gut-spine axis perspective can provide novel insights into the pathogenesis and treatment of SDD.

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Section: Gut-spine Axismentioning

confidence: 99%

Section: Gut-spine Axismentioning

confidence: 99%

Section: Gut-spine Axismentioning

confidence: 99%

See 1 more Smart Citation

Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases

Morimoto,

Kobayashi,

Kakiuchi

et al. 2023

Front. Microbiol.

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A view on the skin–bone axis: unraveling similarities and potential of crosstalk

Morimoto,

Hirata,

Sugita

et al. 2024

Front. Med.

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The phrase “skin as a mirror of internal medicine,” which means that the skin reflects many of the diseases of the internal organs, is a well-known notion. Despite the phenotypic differences between the soft skin and hard bone, the skin and bone are highly associated. Skin and bone consist of fibroblasts and osteoblasts, respectively, which secrete collagen and are involved in synthesis, while Langerhans cells and osteoclasts control turnover. Moreover, the quality and quantity of collagen in the skin and bone may be modified by aging, inflammation, estrogen, diabetes, and glucocorticoids. Skin and bone collagen are pathologically modified by aging, drugs, and metabolic diseases, such as diabetes. The structural similarities between the skin and bone and the crosstalk controlling their mutual pathological effects have led to the advocacy of the skin–bone axis. Thus, the skin may mirror the health of the bones and conversely, the condition of the skin may be reflected in the bones. From the perspective of the skin–bone axis, the similarities between skin and bone anatomy, function, and pathology, as well as the crosstalk between the two, are discussed in this review. A thorough elucidation of the pathways governing the skin–bone axis crosstalk would enhance our understanding of disease pathophysiology, facilitating the development of new diagnostics and therapies for skin collagen-induced bone disease and of new osteoporosis diagnostics and therapies that enhance skin collagen to increase bone quality and density.

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Biomarker Research Approach to the Pathogenesis of Ossification of the Spinal Ligament: A Review

Cited by 2 publications

References 22 publications

Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases

Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases

A view on the skin–bone axis: unraveling similarities and potential of crosstalk

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