Biomarker Potential of Vimentin in Oral Cancers

Mogre, Saie; Makani, Vidhi; Pradhan, Sangram K.; Devre, Pallavi; More, Shyam; Vaidya, Milind M.; Dmello, Crismita

doi:10.3390/life12020150

Cited by 6 publications

(2 citation statements)

References 91 publications

(124 reference statements)

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“…Consistent with these studies, we have demonstrated that vimentin regulates differentiation switching via the modulation of K5/14 transcript levels, perhaps via ΔNP63 signaling. The expression of K5/14 and vimentin correlated with a poor prognosis of oral cancer patients [ 56 , 57 ].…”

Section: Aberrant Expression Of Keratins In Osccmentioning

confidence: 99%

Utility of Keratins as Biomarkers for Human Oral Precancer and Cancer

Vaidya

Dmello

Mogre

2022

Life

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Human oral cancer is the single largest group of malignancies in the Indian subcontinent and the sixth largest group of malignancies worldwide. Squamous cell carcinomas (SCC) are the most common epithelial malignancy of the oral cavity, constituting over 90% of oral cancers. About 90% of OSCCs arise from pre-existing, potentially malignant lesions. According to WHO, OSCC has a 5-year survival rate of 45–60%. Late diagnosis, recurrence, and regional or lymph nodal metastases could be the main causes of the high mortality rates. Biomarkers may help categorize and predict premalignant lesions as high risk of developing malignancy, local recurrence, and lymph nodal metastasis. However, at present, there is a dearth of such markers, and this is an area of ongoing research. Keratins (K) or cytokeratins are a group of intermediate filament proteins that show paired and differentiation dependent expression. Our laboratory and others have shown consistent alterations in the expression patterns of keratins in both oral precancerous lesions and tumors. The correlation of these changes with clinicopathological parameters has also been demonstrated. Furthermore, the functional significance of aberrant keratins 8/18 expression in the malignant transformation and progression of oral tumors has also been documented. This article reviews the literature that emphasizes the value of keratins as biomarkers for the prognostication of human oral precancers and cancers.

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Section: Aberrant Expression Of Keratins In Osccmentioning

confidence: 99%

Utility of Keratins as Biomarkers for Human Oral Precancer and Cancer

Vaidya

Dmello

Mogre

2022

Life

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“…Vimentin is crucial for the EMT, metastasis, and invasion of mesenchymal cells ( Satelli and Li, 2011 ; Usman et al, 2021 ). Hence, no wonder that most studies designated the significance of vimentin as a biomarker in cancers with clinical relevance in several types of cancers ( Ben-Ze’ev and Raz, 1985 ; Hu et al, 2004 ; Jin et al, 2010 ; Li M. et al, 2010 ; Wei et al, 2008 ; Bogush et al, 2020 ) and the more in depth information can be found elsewhere ( Satelli and Li, 2011 ; Zhao et al, 2013 ; Polioudaki et al, 2015 ; Mogre et al, 2022 ). In lung cancers, vimentin has been shown to be the target of various regulating factors that control expression or cause post-translational modification of vimentin.…”

Section: Vimentin Intermediate Filaments In Pathological Roles In Lun...mentioning

confidence: 99%

Pathophysiological Role of Vimentin Intermediate Filaments in Lung Diseases

Surolia

Antony

2022

Front. Cell Dev. Biol.

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Vimentin intermediate filaments, a type III intermediate filament, are among the most widely studied IFs and are found abundantly in mesenchymal cells. Vimentin intermediate filaments localize primarily in the cytoplasm but can also be found on the cell surface and extracellular space. The cytoplasmic vimentin is well-recognized for its role in providing mechanical strength and regulating cell migration, adhesion, and division. The post-translationally modified forms of Vimentin intermediate filaments have several implications in host-pathogen interactions, cancers, and non-malignant lung diseases. This review will analyze the role of vimentin beyond just the epithelial to mesenchymal transition (EMT) marker highlighting its role as a regulator of host-pathogen interactions and signaling pathways for the pathophysiology of various lung diseases. In addition, we will also examine the clinically relevant anti-vimentin compounds and antibodies that could potentially interfere with the pathogenic role of Vimentin intermediate filaments in lung disease.

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