Biomarker in insulin resistant and its complication.

Abstract

Aims: In Type 2 diabetes, Insulin resistant leads microvascular and macrovascular complication. Early finding prevents from this complication and it is a challenging task. A decade research shows adiponectin may be a marker for insulin resistant. Increasing the level of adiponectin prevent the progression of insulin resistant (IR). In this research we are striving adiponectin as a biomarker for insulin resistant also associating the correlation with lipid parameter in the South Indian population. Methods: 30 Type 2 Diabetic patients, 20 Controls were studied. Fasting serum sample were used to measure Adiponectin, Insulin, Lipid parameters (Cholesterol, Triglyceride, HDL) Fasting plasma sample were used to measure Glucose. Anthropometric data including height, weight, BMI and were measured using a standard technique. Results: Wilcoxon signed rank test shows the significant variation between Adiponectin and other analytes. The reduction of mean adiponectin value observed in patient's sample compared to control sample. Insignificant negative correlation between Fasting blood sugar (FBS) and Adiponectin also negative correlation between Adiponectin and Insulin observed. In lipid parameters, significant positive correlation between Adiponectin and HDL and significant negative correlation between Adiponectin and triglyceride observed. Conclusion: Adiponectin might be a prediction for biomarker in Type 2 diabetes associated insulin resistant among South Indians also if test has been done with the high specificity and sensitivity ELISA kit it will improve the insignificant correlation to significant correlation.

Effect of Exercise Training on Some Anti-Inflammatory Adipokines, High Sensitivity C-Reactive Protein, and Clinical Outcomes in Sedentary Adults With Metabolic Syndrome

“…On the other hand, research has shown that a low level of adiponectin, a peptide produced by adipose tissue (Banu & Elango, 2019), is associated with the prevalence of metabolic syndrome (Banu & Elango, 2019; Mohammad Rahimi et al, 2020), insulin resistance (Adiyaman et al, 2020), coronary heart disease (Lindberg et al, 2017), and diseases related to inflammation (Mohammad Rahimi et al, 2022). Elevated levels of adiponectin promote insulin sensitivity in skeletal muscles by binding to adiponectin receptor type 1 and 2, which triggers the activation of several signaling pathways (Roy & Palaniyandi, 2021).…”