2023
DOI: 10.1136/bmjopen-2022-070240
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Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Abstract: IntroductionPrevious studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysisThe BigpAK-2 trial is an international, randomised, controlled, multicentre trial.… Show more

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Cited by 3 publications
(1 citation statement)
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“…The biomarker-guided KDIGO bundle has been shown in previous Prev-AKI trials to be effective in reducing AKI in cardiac surgery patients [121, 122]. Moreover, multiple BIGPAC trials have shown that early biomarker-based prediction of AKI after implementation of the KDIGO care package reduces the risk of postoperative AKI [123, 124]. Anesthetics can improve the level of traditional biomarkers, while the new biomarkers applied by care bundle can be diagnosed earlier.…”
Section: Novel Combination: Anesthetics With the Care Bundlementioning
confidence: 99%
“…The biomarker-guided KDIGO bundle has been shown in previous Prev-AKI trials to be effective in reducing AKI in cardiac surgery patients [121, 122]. Moreover, multiple BIGPAC trials have shown that early biomarker-based prediction of AKI after implementation of the KDIGO care package reduces the risk of postoperative AKI [123, 124]. Anesthetics can improve the level of traditional biomarkers, while the new biomarkers applied by care bundle can be diagnosed earlier.…”
Section: Novel Combination: Anesthetics With the Care Bundlementioning
confidence: 99%