Biomarker discovery and validation: technologies and integrative approaches

Ilyin, Sergey E.; Belkowski, Stanley M.; Plata‐Salamán, Carlos R.

doi:10.1016/j.tibtech.2004.06.005

Cited by 166 publications

(95 citation statements)

References 23 publications

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“…Summarily, biomarkers are entities within the body capable of providing impartial information regarding the current physiologic state of a living organism (29).…”

Section: Biomarkers and Clinical Realitymentioning

confidence: 99%

Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities

et al. 2013

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SUMMARY The pursuit of timely, cost-effective, accurate, and noninvasive diagnostic methodologies is an endeavor of urgency among clinicians and scientists alike. Detecting pathologies at their earliest stages can significantly affect patient discomfort, prognosis, therapeutic intervention, survival rates, and recurrence. Diagnosis and monitoring often require painful invasive procedures such as biopsies and repeated blood draws, adding undue stress to an already unpleasant experience. The discovery of saliva-based microbial, immunologic, and molecular biomarkers offers unique opportunities to bypass these measures by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Here we discuss saliva and its significance as a source of indicators for local, systemic, and infectious disorders. We highlight contemporary innovations and explore recent discoveries that deem saliva a mediator of the body's physiological condition. Additionally, we examine the current state of salivary diagnostics and its associated technologies, future aspirations, and potential as the preferred route of disease detection, monitoring, and prognosis.

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“…Summarily, biomarkers are entities within the body capable of providing impartial information regarding the current physiologic state of a living organism (29).…”

Section: Biomarkers and Clinical Realitymentioning

confidence: 99%

Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities

et al. 2013

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“…131 Table 4 provides an overview of some key techniques used for identifying putative CVD biomarkers. 133 Table 5 defines broadly these "Omics" tools. 134 -137 Table 6 provides information about some of the mathematical and molecular biological techniques within the "Omics" toolbox.…”

Section: Biomarker Discovery: Molecular Biology Toolsmentioning

confidence: 99%

Biomarkers of Cardiovascular Disease

2006

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“…Companies may purchase tissue from a vendor that specializes in tissue (e.g., Asterand, Cooperative Human Tissue Network, National Disease Research Interchange, and/or Ontario Tissue Bank) or enter into a customized agreement with a hospital or consortium of hospitals. 12,15 Although there are advantages and disadvantages to each route, this article focused on the latter.…”

Section: Sourcing Human Tissuementioning

confidence: 99%