Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project

Goode, Adam P.; Hu, David; George, Steven Z.; Schwartz, Todd A.; Kraus, Virginia B.; Huebner, Janet L.; Cleveland, Rebecca J.; Taylor, Kenneth A.; Jordan, Joanne M.; Golightly, Yvonne M.

doi:10.1016/j.ocarto.2022.100270

Cited by 10 publications

(8 citation statements)

References 41 publications

(68 reference statements)

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“…To examine reported association of these markers with painful conditions, we performed a rapid review which retrieved 211 studies, of which 17 were included in the final analysis. 18,39,[55][56][57][58][59][60][61][62][63][64][65][66][67][68] Several chemokines, including CCL3, 4, 5, and 24 and CXCL5 and 10, were reported to be negatively associated with pain, specifically with CNMP, PP, BP, and OA (Figure 2B). CXCL8, most reported for its association with painful conditions, was also reported to be both positively and negatively associated with pain outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…To examine reported association of these markers with painful conditions, we performed a rapid review which retrieved 373 studies, of which 24 were included in the final analysis. 56, Bone 3B). Thus, the increase in bone resorption marker NTX in astronauts is similar to the commonly reported increase in BRM in painful musculoskeletal conditions, however MMP9 was consistently decreased in astronauts and bone formation marker, PINP was variably affected.…”

Section: Resultsmentioning

confidence: 99%

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Markers of Tissue Deterioration and Pain on Earth and in Space

Patron,

Neset,

Mielkozorova

et al. 2024

JPR

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Purpose Pain is an understudied physiological effect of spaceflight. Changes in inflammatory and tissue degradation markers are often associated with painful conditions. Our aim was to evaluate the changes in markers associated with tissue deterioration after a short-term spaceflight. Patients and Methods Plasma levels of markers for systemic inflammation and tissue degeneration markers were assessed in two astronauts before and within 24 h after the 17-day Axiom Space AX-1 mission. Results After the spaceflight, C-reactive protein (CRP) was reduced in both astronauts, while INFγ, GM-CSF, TNFα, BDNF, and all measured interleukins were consistently increased. Chemokines demonstrated variable changes, with consistent positive changes in CCL3, 4, 8, 22 and CXCL8, 9, 10, and consistent negative change in CCL8. Markers associated with tissue degradation and bone turnover demonstrated consistent increases in MMP1, MMP13, NTX and OPG, and consistent decreases in MMP3 and MMP9. Conclusion Spaceflight induced changes in the markers of systemic inflammation, tissue deterioration, and bone resorption in two astronauts after a short, 17-day, which were often consistent with those observed in painful conditions on Earth. However, some differences, such as a consistent decrease in CRP, were noted. All records for the effect of space travel on human health are critical for improving our understanding of the effect of this unique environment on humans.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Markers of Tissue Deterioration and Pain on Earth and in Space

Patron,

Neset,

Mielkozorova

et al. 2024

JPR

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“…Lumican has been proposed as a discriminative biomarker of lumbar intervertebral disc degeneration (IVDD) and low back pain (LBP) [ 64 ] and a longitudinal baseline biomarker reflective of the disc space narrowing, vertebral osteophyte formation, inflammatory marker upregulation and increased mechanosensitivity displayed in IVDD, which correlates with elevated LBP levels [ 65 ]. An evaluation of the inflammatory profile of herniated IVDs using proteomic and bioinformatics methodologies found elevated LUM levels in IVD tissues correlated with elevated Modic scores and endplate avulsion [ 66 ].…”

Section: Lumican and Musculoskeletal Diseasementioning

confidence: 99%

Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

Smith,

Melrose

2024

IJMS

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This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby regulating cell proliferation, differentiation, inflammation and the innate and humoral immune systems to combat infection. The exponential increase in publications in the last decade dealing with lumican testify to its role as a pleiotropic biomarker regulatory protein. Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 infections; thus, it may also prove useful in the delineation of the complex tissue changes that characterize COVID-19 disease. Lumican may be useful as a prognostic and diagnostic biomarker of long COVID disease and its sequelae.

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“…33,34 In chronic MSK conditions such as osteoarthritis and low back pain, studies have shown that inflammatory cytokines and redox signalling biomarkers, which play a crucial role in regulating inflammatory responses, may be used to identify patients with a higher likelihood of presenting lower physical function, higher pain intensity, greater pain catastrophizing, and multiple painful areas (widespread pain). 16,35 Thereby, treatment strategies that aim to modify these biomarkers are of great relevance. In this regard, the findings from the present study are of great potential given the 400N and 800N SMT's ability to modify systemic oxidative stress biomarkers, which is in agreement with pre-clinical and clinical evidence that SMT can modulate oxidants and antioxidant biomarkers while improving pain and physical function.…”

Section: Systemic Redox Signalling Biomarkers Have Promising Clinical...mentioning

confidence: 99%

Preliminary Insights into the Effects of Spinal Manipulation Therapy of Different Force Magnitudes on Blood Biomarkers of Oxidative Stress and Pro-Resolution of Inflammation Mediators

Duarte,

Funabashi,

Starmer

et al. 2023

Preprint

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IntroductionEvidence has reported that spinal manipulation therapy (SMT) leads to spine segmental hypoalgesia through neurophysiological and peripheral mechanisms related to regulating inflammatory biomarker function. However, these studies also showed substantial inter-individual variability in the biomarker responses. Such variability may be due to the incomplete understanding of the fundamental effects of force-based manipulations (e.g., patient-specific force-time characteristics) on a person’s physiology in health and disease. This study investigated the short-term effects of distinct SMT force-time characteristics on blood oxidative stress and pro-resolution of inflammation biomarkers.MethodsNineteen healthy adults were clustered into three groups: control (preload only), target total peak force of 400N, and 800N. A validated force-sensing table technology (FSTT®) determined the SMT force-time characteristics. Blood samples were collected at pre-intervention, immediately after SMT, and 20 minutes post-intervention. Parameters of the oxidant system (total oxidant status, lipid peroxidation and lipid hydroperoxide), the antioxidant system (total antioxidant capacity and bilirubin), and lipid-derived resolvin D1 were evaluated in plasma and erythrocytes through enzyme-linked immunosorbent assay and colorimetric assays.ResultsOverall, 400N seemed to decrease blood oxidants, and 800N generally increased blood oxidants, decreased antioxidants and resolvin D1 mediatorConclusionOur findings indicate that different single SMT force-time characteristics presented contrasting effects on the systemic redox signalling biomarkers and pro-resolution of inflammation mediators in healthy participants, providing baseline information and direction for future studies in a clinical population.

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Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project

Cited by 10 publications

References 41 publications

Markers of Tissue Deterioration and Pain on Earth and in Space

Markers of Tissue Deterioration and Pain on Earth and in Space

Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

Preliminary Insights into the Effects of Spinal Manipulation Therapy of Different Force Magnitudes on Blood Biomarkers of Oxidative Stress and Pro-Resolution of Inflammation Mediators

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