Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance from Helicobacter pylori Next Generation Sequencing Data

Vital, Joana S.; Tanoeiro, Luís; Lopes-Oliveira, Ricardo; Vale, Filipa F.

doi:10.3390/biom12050691

Cited by 23 publications

(24 citation statements)

References 260 publications

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“…The presence of mutations in genes that are known to be associated with CD provided evidence that microbiota play a part in the pathogenesis of the illness. This might be accomplished by a change in the immune response, mucosal permeability, or the metabolic products of microbes [48][49][50][51][52]. Antibiotics and probiotics are two examples treatments targeting bacteria, and there has been a recent increase of the use of both approaches.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

Helicobacter Pylori Infection Correlates with Lower Prevalence and Subsequent Incidence of Crohn’s Disease

Hu¹,

Lei²,

Tai³

et al. 2024

Helicobacter Pylori Infection - An Up to Date on the Pathogenic Mechanisms, Diagnosis and Clinical Management

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According to some researchs, Crohn’s disease (CD) and Ulcerative colitis (UC), two chronic inflammatory bowel illnesses, may be protected against Helicobacter pylori infection. Many case–control studies have revealed that individuals with CD and UC had lower H. pylori prevalence than healthy controls. However, whether or not H. pylori plays a protective role in the development of Crohn’s disease is debatable. CD was more common in H. pylori-negative individuals than in H. pylori-positive patients. After eradication of H. pylori, the CD was more common in the H. pylori-negative group than in the H. pylori-positive group over the previous research follow-up period. Although it has been strongly indicated in previous studies that H. pylori infection plays a significant role and triggers autoimmune reactions and may be implicated in the pathogenesis of autoimmune diseases, the role of H. pylori in inflammatory bowel disease, including Crohn’s disease, is unclear.

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Section: Molecular Mechanismsmentioning

confidence: 99%

Helicobacter Pylori Infection Correlates with Lower Prevalence and Subsequent Incidence of Crohn’s Disease

Hu¹,

Lei²,

Tai³

et al. 2024

Helicobacter Pylori Infection - An Up to Date on the Pathogenic Mechanisms, Diagnosis and Clinical Management

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“…Тому в багатьох державах Європи та Америки розроблено стандарти лікування інфекції H.pylori у хворих на виразкову хворобу [7,8]. Елімінація мікроорганізмів із шлункової слизової оболонки значно знижує частоту виникнення ускладнень виразкової хвороби [9]. Однак практичний досвід показує, що антихелікобактерна терапія супроводжується у частини хворих виникненням несприятливих побічних реакцій.…”

Section: резюмеunclassified

Effectiveness of the modified scheme for treatment of Н.pylori-associated peptic ulcer of the duodenum in children

Sorokman

Moldovan

2022

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Background. None of the known regimens for the treatment of H.pylori-associated peptic ulcer of the duodenum (PUD) is 100 % effective. The purpose was to evaluate the effectiveness of the modified comprehensive therapy for Н.pylori-associated peptic ulcer of the duodenum in children. Materials and methods. The study included 66 patients aged 7 to 18 years with Н.pylori-associated PUD in the acute stage. Serum vitamin D levels were measured using the electrochemiluminescence method (Roche Diagnostics GmbH, Mannheim, Germany). The classical method of stool culture was used. The children were divided into three groups: the first — 20 patients who received protocol eradication therapy, the second — 23 children who received modified comprehensive therapy with the inclusion of vitamin D3, the third — 23 patients who received modified comprehensive therapy with the inclusion of vitamin D3 and a synbiotic. Results. The average length of stay in the hospital for patients who received modified therapy with the inclusion of vitamin D3 was reduced by 18.8 %, and in those who received synbiotic additionally — by 23.8 % compared to the first group. During the endoscopic examination conducted after 1 month, the presence of an elongated red scar at the site of the ulcer defect was observed significantly more often in group I (65.5 %) than in groups II (47.8 %) and III (39.1 %), χ2 = 3.87, p < 0.05; after 1 year, 33.3 % of children in group I, 17.3 % in group II, and 8.7 % in group III (p < 0.01) had a recurrence of the disease. The determination of the main indicators for the effectiveness of PUD treatment using a modified scheme showed that the relative risk of disease recurrence will decrease by 0.42 times (χ2 = 3.96, p < 0.05) when vitamin D3 preparation is included in the treatment scheme and by 0.52 times (χ2 = 4.06, p < 0.01) when using vitamin D3 and a synbiotic. Conclusions. 1. Children with Н.pylori-associated peptic ulcer of the duodenum have vitamin D3 deficiency and various disturbances of the intestinal microbiota, which can complicate the course, increase the chronicity of the process, and reduce the effectiveness of anti-Helicobacter therapy. 2. The use of a modified comprehensive treatment for duodenal ulcer associated with H.pylori leads to a reduction in the duration of the main clinical manifestations of the disease, the duration of inpatient treatment of sick children and a decrease in the frequency of recurrence of the disease.

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“…The outer membrane porins (Hop) or Hop-related proteins (Hor) are responsible for the transport of various molecules, including antibiotics, by passive diffusion. The adhesins SabA and BabA bind epithelial cells; the iron-regulated outer membrane proteins, which include the FecA- and FrpB-like proteins, bind heme and hemoglobin; the efflux pump outer membrane proteins, which expel various molecules from the bacterial cytoplasm; the Hof and Hom families, which are involved in adhesion to gastric cells [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Implications of Helicobacter pylori Antibiotic Resistance in Italy: A Review of the Literature

et al. 2022

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Helicobacter pylori (H. pylori) resistance to antibiotics has increased worldwide in recent decades, especially to clarithromycin. As a result, the World Health Organization (WHO) identified clarithromycin-resistant H. pylori as a “high priority” pathogen in 2017. As international guidelines recommend empirical therapy as first-line treatment, it is crucial to know local resistance rates and history of antibiotic use to determine the most appropriate first-line antibiotic treatment. Italy is one of the European countries with the highest prevalence of H. pylori infection and the highest percentage of antibiotic-resistant H. pylori. The aim of this review is to summarize all data on H. pylori antibiotic resistance in Italy in order to quantify the current rate and determine the most effective therapeutic approach. The study confirms an elevated level of resistance to clarithromycin, metronidazole, and levofloxacin in Italy. In addition, our results show a satisfactory eradication rate for a bismuth-based regimen when used as first- or second-line treatment. Naive patients are also successfully treated with clarithromycin-based quadruple therapies. Considering the good results of bismuth-based therapy as recovery therapy, this argues for the potential use of clarithromycin quadruple therapy as a first-line treatment.

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Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance from Helicobacter pylori Next Generation Sequencing Data

Cited by 23 publications

References 260 publications

Helicobacter Pylori Infection Correlates with Lower Prevalence and Subsequent Incidence of Crohn’s Disease

Helicobacter Pylori Infection Correlates with Lower Prevalence and Subsequent Incidence of Crohn’s Disease

Effectiveness of the modified scheme for treatment of Н.pylori-associated peptic ulcer of the duodenum in children

Clinical Implications of Helicobacter pylori Antibiotic Resistance in Italy: A Review of the Literature

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