Biomarker Associations in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Spantler, Dora; Molnár, Tihamér; Simon, Diána; Berki, Tímea; Büki, András; Schwarcz, Attila; Csécsei, Péter

doi:10.3390/ijms23158789

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Few observational studies had been conducted to investigate the relationship between FGFs and IA, most of which focused on FGF-2 (also known as bFGF). It was reported that higher expression level of FGF-2 was associated with IA and might contribute to vascular remodeling [31], while contradictory nding revealed that the expression pattern of FGF-2 did not differ in normal arterial, ruptured aneurysm, or unruptured aneurysm wall [32,33]. Evidence provided by in vitro and in vivo experimental studies showed that cellular proliferation, tissue brosis, and vascular wall thickness were enhanced by FGF-2 in aneurysm models [34,35].…”

Section: Discussionmentioning

confidence: 98%

Circulating Inflammatory Biomarkers and Risk of Intracranial Aneurysm: A Mendelian Randomization Study

Fang

Cao

2023

Preprint

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Background Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design. Methods For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8,293 Finnish participants. Summary data of IA was extracted from a GWAS which comprised 7,495 cases and 71,934 controls in European descent. For targeted analysis, summary statistics were extracted from two proteomic studies, which recruit 3,301 and 5,368 European participants, respectively. Summary data of IA were acquired from FinnGen study with 5,342 cases and 342,673 controls. We employed inverse variance weighted (IVW) method as main approach, with sensitivity analyses using weighted median, MR-Egger, and MR-PRESSO methods. Reverse MR analyses were conducted to minimize bias from reverse causality. Results No causation of cytokines with IA was identified in both primary and targeted analysis after Bonferroni correction. In primary analysis, vascular endothelial growth factor (VEGF) and fibroblast growth factor basic (bFGF) levels were suggestively associated with IA [(VEGF→IA: odds ratio (OR) = 1.11, 95% confidence interval (95% CI) = 1.02–1.20, P = 0.01; bFGF→IA: OR = 0.68, 95% CI = 0.48–0.96, P = 0.03]. Statistical significance failed to replicate in targeted analysis. Instead, suggestive protective effects for aneurysmal subarachnoid hemorrhage (aSAH) were identified in FGF-9 (FGF-9→aSAH: OR = 0.74, 95% CI = 0.62–0.89, P = 0.001) and FGF-16 (FGF-16→aSAH: OR = 0.84, 95% CI = 0.72–0.97, P = 0.017). Furthermore, reverse analyses identified suggestive effect of IA and its subtypes on IL-10, RANTES, MIF, GRO-alpha, FGF-16, and FGF-19. Result remained robust after applying sensitivity tests. Conclusions Our study provided novel insights into the potential protective role of FGF-9 and FGF-16 in aSAH. Future studies are in need to evaluate the temporal dynamics of cytokines in conjunction with IA.

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Section: Discussionmentioning

confidence: 98%

Circulating Inflammatory Biomarkers and Risk of Intracranial Aneurysm: A Mendelian Randomization Study

Fang

Cao

2023

Preprint

View full text Add to dashboard Cite

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“…Few observational studies had been conducted to investigate the relationship between FGFs and IA, most of which focused on FGF-2 (also known as bFGF). It was reported that higher expression level of FGF-2 was associated with IA and might contribute to vascular remodeling [ 32 ], while contradictory finding revealed that the expression pattern of FGF-2 did not differ in normal arterial, ruptured aneurysm, or unruptured aneurysm wall [ 33 , 34 ]. Evidence provided by in vitro and in vivo experimental studies showed that cellular proliferation, tissue fibrosis, and vascular wall thickness were enhanced by FGF-2 in aneurysm models [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study

Fang,

Cao,

2024

Eur J Med Res

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Background Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design. Methods For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8293 Finnish participants. Summary data of IA were extracted from a GWAS which comprised 7495 cases and 71,934 controls in European descent. For targeted analysis, summary statistics were extracted from two proteomic studies, which recruit 3301 and 5368 European participants, respectively. Summary data of IA were acquired from FinnGen study with 5342 cases and 342,673 controls. We employed inverse variance weighted (IVW) method as main approach, with sensitivity analyses using weighted median, MR-Egger, and MR-PRESSO methods. Reverse MR analyses were conducted to minimize bias from reverse causality. Results No causation of cytokines with IA subtypes was identified in both primary and targeted analysis after Bonferroni correction. In primary analysis, vascular endothelial growth factor (VEGF) and fibroblast growth factor basic (bFGF) levels were suggestively associated with aneurysmal subarachnoid hemorrhage (aSAH) [VEGF → aSAH: OR = 1.15, 95%CI 1.04–1.26, P = 0.005; bFGF → aSAH: OR = 0.62, 95% CI 0.42–0.92, P = 0.02]. Statistical significance failed to replicate in targeted analysis. Instead, suggestive protective effects for aSAH were identified in FGF-9 (FGF-9 → aSAH: OR = 0.74, 95% CI 0.62–0.89, P = 0.001) and FGF-16 (FGF-16 → aSAH: OR = 0.84, 95% CI 0.72–0.97, P = 0.017). Furthermore, reverse analyses identified suggestive effect of unruptured IA on RANTES, MIF, GRO-alpha, FGF-16, and FGF-19. Result remained robust after applying sensitivity tests. Conclusions No causality of inflammatory biomarkers on the risk of IA subtypes was identified. Future large-scale studies are in need to evaluate the temporal dynamics of cytokines in conjunction with IA.

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“…Spantler et al ( 43 ) analyzed a multiplex serum biomarker in 112 patients with aSAH at two time points. Their findings illustrated that monocyte chemotactic protein-3 and chemokine (C-X3-C motif) ligand-1 concentrations at Day 5–7 were relevant to DCI after aSAH.…”

Section: Application Of Peripheral Blood Biomarkers In Ruptured Intra...mentioning

confidence: 99%

Potential application of peripheral blood biomarkers in intracranial aneurysms

Wu,

Zhao,

Kang

et al. 2023

Front. Neurol.

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Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis and treatment rely on costly equipment, lacking effective indicators for progression prediction and specific drugs for treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune and inflammatory state of the body in real-time, have shown promise in providing additional information for risk stratification and treatment in IA patients, which may improve their outcomes after aneurysm rupture through anti-inflammatory therapy. Therefore, this paper reviewed the progress of potential biomarkers of IAs, including inflammatory blood indicators, cytokines, and blood lipids, aiming to aid individual management and therapy of aneurysms in clinical practices.

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Biomarker Associations in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Cited by 5 publications

References 46 publications

Circulating Inflammatory Biomarkers and Risk of Intracranial Aneurysm: A Mendelian Randomization Study

Circulating Inflammatory Biomarkers and Risk of Intracranial Aneurysm: A Mendelian Randomization Study

Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study

Potential application of peripheral blood biomarkers in intracranial aneurysms

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