Biomarcadores de estrés oxidativo como indicadores de actividad en la enfermedad articular inflamatoria crónica

Feijóo, Montserrat; Túnez, Isaac; Ruíz, A Trujillano; Tasset, Inmaculada; Muñoz, Elisa; Collantes, Eduardo

doi:10.1016/j.reuma.2008.12.016

Cited by 19 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Presence of lipid molecules and pale macroscopic appearance of the liver indicated possible hepatotoxicity. 19 Liver weight gain can also be attributed to the adaptive mechanism of the hepatocytes in counteracting the toxic effect of the CCl 4 by hypertrophy. 11 This might also be due to the infiltration of the liver by inflammatory cells subsequently resulting in liver necrosis.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats

Genfi

Larbie

Emikpe

et al. 2020

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

Liver diseases have now become a global canker due to increasing drug abuse and several viral infections. The current medicines on the market are woefully inadequate and limited in the application against these diseases. Fortunately, medicinal plants continue to serve as a potential source of drug discovery that could be explored to improve the situation. The present study, therefore, evaluated the hepatoprotective activities of the aqueous extract of various parts (leaves, flower and stem) of Ocimum americanum L on carbon tetrachloride (CCl4)- and acetaminophen-induced toxicity in rats. The protective effect of the plant was assessed using biochemical parameters, histology, levels of liver antioxidants, and expression of some pro-inflammatory cytokines (NF-κβ and IL-1) in the liver. The leaves and stem extracts, orally administered for 7 days at 250 mg/kg, effectively prevented CCl4-induced elevation of serum biochemical parameters, prooxidants, as well as the expression of NFk-B and IL-1, which were comparable to Silymarin (standard drug). A comparative histopathological analyses of the liver exhibited virtually normal architecture compared with CCl4-treated group. The findings showed that the hepatoprotective effect of Ocimum americanum was probably due to the inhibition of oxidative stress and downregulation of proinflammatory cytokines by the effective parts of the medicinal plant.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats

Genfi

Larbie

Emikpe

et al. 2020

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

show abstract

“…Since HNE, a major aldehydic product of lipid peroxidation, is believed to be largely responsible for cytopathological effects observed during oxidative stress [ 1 – 3 ], we studied the effect of C. nudiflora against CCl 4 -induced formation of HNE-modified protein adducts in the liver. The production of HNE-modified protein adducts is indicated by the appearance of yellow coloration (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, liver diseases pose serious health issues. Environmental pollutants, infectious agents, and hepatotoxins (carbon tetrachloride) are reported to cause liver injuries [ 1 , 2 ]. Carbon tetrachloride (CCl 4 ) is a compound that is most commonly used to induce liver injuries in experimental animals [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The potential protective effect of Commelina nudiflora L. against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, mediated by suppression of oxidative stress and inflammation

Shah

D'Souza

Iqbal

2017

Environ Health Prev Med

View full text Add to dashboard Cite

BackgroundThis study aims to assess the hepatoprotective potential of Commelina nudiflora against CCl4-induced hepatic injury in rats.MethodAntioxidant activities were determined. Phytochemical analysis was performed by gas chromatography mass spectrometry (GCMS). In the in vivo study, Sprague Dawley rats were pretreated with C. nudiflora (150, 300, and 450 mg kg body weight (b.wt.)) once daily for 14 days followed by two doses of CCl4 (1 ml/kg b.wt.). After 2 weeks, the rats were sacrificed and hepatoprotective analysis was performed.ResultsIn vitro studies have shown that the extract possessed strong antioxidant activity and has ability to scavenge 2,2-diphenyl-2-picrylhydrazyl-free radicals effectively. GCMS analysis of the C. nudiflora extract revealed the presence of various bioactive compounds. Administration of C. nudiflora significantly reduced the impact of CCl4 toxicity on serum markers of liver damage, serum aspartate transaminase (AST), and alanine transaminase (ALT). C. nudiflora also increased antioxidant levels of hepatic glutathione (GSH) and antioxidant enzymes and ameliorated the elevated hepatic formation of malondialdehyde (MDA) induced by CCl4 in rats. Histopathological examination indicated that C. nudiflora protect the liver from the toxic effect of CCl4 and healed lesions such as necrosis, fatty degeneration, and hepatocyte injury as irregular lamellar organization and dilations in the endoplasmic reticulum. The immunohistochemical studies revealed that pretreatment of C. nudiflora decreased the formation of 4-hydroxy-2-nonenal (HNE)-modified protein adducts and 8-hydroxy-2′-deoxyguanosine (8-OHdG). Furthermore, overexpression of the proinflammatory cytokines TNF-α, IL-6, and prostaglandin E2 is also reduced.ConclusionThese findings exhibited the potential prospect of C. nudiflora as functional ingredients to prevent ROS-related liver damage.

show abstract

“…The oxygen radicals such as superoxide, hydroxyl radicals, and non-free radical species (H 2 O 2 ), and singlet oxygen are generated in many redox processes of normal physiochemical pathways. 4,5 Antioxidants trap and destroy these radicals. Vitamin deficiency, overproduction of free radicals and reduced antioxidants were considered predisposed factors of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin deficiency, overproduction of free radicals and reduced antioxidants were considered predisposed factors of oxidative stress. 5 Over the past few years research on oxidants and antioxidants has shown a link between most diseases such as cardiovascular disease, cancer, osteoporosis, degenerative diseases, etc., and production of reactive oxygen species (ROS) along with oxidative stress. [6][7][8] Hepatitis is one of the most prevalent diseases in the world.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats

Ayyanna¹,

Mounika²,

Yella³

et al. 2021

JYP

View full text Add to dashboard Cite

The leaves were collected from Tirumala hills. The voucher number is 1146. ExtractionThe collected whole plant of Tephrosia villosa was washed thoroughly with water and dried in the shade. The dried powder was defatted with n-hexane using Soxhlet apparatus. The defatted powder was dried at room temperature and then extracted using 95% ethanol by continuous hot percolation until the clear liquid was obtained in the siphon tube. After completing the extraction, the solvent was removed by steam distillation method to get a solid mass. After obtaining the Whole plant of Tephrosia villosa extract, the phytochemical screening was carried out to identify the various components in the extract.

show abstract

Biomarcadores de estrés oxidativo como indicadores de actividad en la enfermedad articular inflamatoria crónica

Cited by 19 publications

References 15 publications

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats

The potential protective effect of Commelina nudiflora L. against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, mediated by suppression of oxidative stress and inflammation

Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats

Contact Info

Product

Resources

About