Biomanufacturing of glycosylated antibodies: Challenges, solutions, and future prospects

Dubey, Kashyap Kumar; Kumar, Akshay; Baldia, Anshu; Rajput, Deepanshi; Kateriya, Suneel; Singh, Rajani; Nikita,; Tandon, Ravi; Mishra, Yogendra Kumar

doi:10.1016/j.biotechadv.2023.108267

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“… 26 Recent advances in protein engineering and the ability to intentionally introduce chemical and structural modifications have created a paradigm shift in the fine-tuning of protein properties. 18 These advancements have enabled researchers to modify proteins at the molecular level, allowing precise control over their functional properties. 27 This capability has opened new avenues for the design of protein-based therapeutics with enhanced efficacy and stability, optimized pharmacokinetics and reduced immunogenicity.…”

Section: Introductionmentioning

confidence: 99%