Biomagnetic of Apatite-Coated Cobalt Ferrite: A Core–Shell Particle for Protein Adsorption and pH-Controlled Release

Abstract

Magnetic nanoparticle composite with a cobalt ferrite (CoFe2O4, (CF)) core and an apatite (Ap) coating was synthesized using a biomineralization process in which a modified simulated body fluid (1.5SBF) solution is the source of the calcium phosphate for the apatite formation. The core–shell structure formed after the citric acid–stabilized cobalt ferrite (CFCA) particles were incubated in the 1.5 SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of 15.56 emug-1 and a coercivity of 1808.5 Oe were observed for the CFCA-Ap obtained. Bovine serum albumin (BSA) was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution, thus indicating that the BSA release is dependent on the local pH.

Surface reactivity of hydroxyapatite nanocoatings deposited on iron oxide magnetic spheres toward toxic metals

“…The hydroxyapatite coating procedure was adapted from previous reports and summarized in Scheme 1 [15,29]. In a first step, 1 g of the iron oxide spheres was dispersed into 35 mL of a…”

“…The latter applications are related to its wellknown ability to immobilize divalent and tri-valent metal ions, either by partial cationic exchange with calcium ions or via a dissolution/reprecipitation reaction [8][9][10][11][12] Recently, the possibility to combine the properties of hydroxyapatite with other inorganic phases within core-shell nanostructures has attracted great attention. For instance, lanthanide-doped hydroxyapatite/silica [13], hydroxyapatite/TiO 2 [14] and hydroxyapatite/cobalt ferrite [15] core-shell nanoparticles have been studied for fluorescence imaging, photocatalytic processes and drug delivery, respectively. The association of hydroxyapatite with iron oxide particles provides a promising method to design sorbents that combines large sorption capacities and easy recovery via magnetic separation [16,17].…”

Double-perovskite magnetic La2NiMnO6 nanoparticles for adsorption of bovine serum albumin applications

“…Recently, magnetic nanoparticles, such as CoFe 2 O 4 , MnFe 2 O 4 , Fe 2 O 3 , Fe 3 O 4 , and Fe [6-10], have been studied mostly for biomedical applications, but the application of double-perovskite La 2 NiMnO 6 nanoparticles in biomedical has not been reported. Double-perovskite La 2 NiMnO 6 is a ferromagnetic material and attractive due to its impressive properties.…”

SPE and purification of DNA using magnetic particles

“…Especially PEGs with long polymeric chains, which are highly water‐soluble and to a large extent non‐toxic, have found significant applications in the structure stabilisation and delivery of drug biological molecules . The shell can also be prepared with inert materials such as calcium phosphate or apatite .…”