Bioluminescence resonance energy transfer using luciferase-immobilized quantum dots for self-illuminated photodynamic therapy

Hsu, Chih-Yu; Chen, Ching-Wen; Yu, Hsiu-Ping; Lin, Yanfu; Lai, Ping‐Shan

doi:10.1016/j.biomaterials.2012.08.044

Cited by 144 publications

(163 citation statements)

References 41 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…664 By chemically stimulating QD emission with BRET in situ, utilizing the excitation approach demonstrated in the seminal earlier work of Rao, 69 the authors demonstrated a way to potentially overcome the limitations of light penetration into deep tissue if the QD complex is effectively targeted to specific disease locations. An overview of the approach is shown in Figure 131A.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications

Spillmann²,

et al. 2016

View full text Add to dashboard Cite

Luminescent semiconductor quantum dots (QDs) are one of the more popular nanomaterials currently utilized within biological applications. However, what is not widely appreciated is their growing role as versatile energy transfer (ET) donors and acceptors within a similar biological context. The progress made on integrating QDs and ET in biological configurations and applications is reviewed in detail here. The goal is to provide the reader with (1) an appreciation for what QDs are capable of in this context, (2) how this field has grown over a relatively short time span, and, in particular, (3) how QDs are steadily revolutionizing the development of new biosensors along with a myriad of other photonically active nanomaterial-based bioconjugates. An initial discussion of QD materials along with key concepts surrounding their preparation and bioconjugation is provided given the defining role these aspects play in the QDs ability to succeed in subsequent ET applications. The discussion is then divided around the specific roles that QDs provide as either Förster resonance energy transfer (FRET) or charge/electron transfer donor and/or acceptor. For each QD-ET mechanism, a working explanation of the appropriate background theory and formalism is articulated before examining their biosensing and related ET utility. Other configurations such as incorporation of QDs into multistep ET processes or use of initial chemical and bioluminescent excitation are treated similarly. ET processes that are still not fully understood such as QD interactions with gold and other metal nanoparticles along with carbon allotropes are also covered. Given their maturity, some specific applications ranging from in vitro sensing assays to cellular imaging are separated and discussed in more detail. Finally a perspective on how this field will continue to evolve is provided.

show abstract

Section: Photodynamic Therapymentioning

confidence: 99%

Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications

Spillmann²,

et al. 2016

View full text Add to dashboard Cite

show abstract

“…2, 3 A recent advanced approach that attempted to overcome the limitation of tissue penetration of light is the use of chemi/bioluminescent systems that can avoid the external light and use chemi/bioluminescence is an internal light source. 4, 5 …”

Section: Introductionmentioning

confidence: 99%

Cerenkov Radiation Induced Photodynamic Therapy Using Chlorin e6-Loaded Hollow Mesoporous Silica Nanoparticles

Kamkaew¹,

Cheng

Goel³

et al. 2016

ACS Appl. Mater. Interfaces

144

113

View full text Add to dashboard Cite

Traditional photodynamic therapy (PDT) requires external light to activate photosensitizers for therapeutic purposes. However, the limited tissue penetration of light is still a major challenge for this method. To overcome this limitation, we report an optimized system that uses Cerenkov radiation for PDT by using radionuclides to activate a well-known photosensitizer (Chlorin e6, Ce6). By taking advantage of hollow mesoporous silica nanoparticles (HMSNs) that can intrinsically radiolabel oxophilic zirconium-89 (89Zr, t1/2 = 78.4 h) radionuclide, as well as possess great drug loading capacity, Ce6 can be activated by Cerenkov radiation from 89Zr in the same nanoconstruct. In vitro cells viability experiments demonstrated dose-dependent cell deconstructions as a function of concentration of Ce6 and 89Zr. In vivo studies show inhibition of tumor growth when mice were subcutaneously injected with [89Zr]HMSN-Ce6 and histological analysis of tumor section showed damage to tumor tissues, implying that reactive oxygen species mediated the destruction. This study offers a way to use internal radiation source to achieve deep-seated tumor therapy without using any external light source for future applications.

show abstract

“…Therefore, alternative approaches to PDT have been attempted using a new type of excitation that employs light generated inside of the body by CL instead of using an external light source [138,139]. The endogenous light generation by CL is also useful for autofluorescence-free diagnostic imaging with high sensitivity.As an example, thermally controllable polymeric NPs were devised for in vivo imaging [140,141].…”

Section: Chemi-and Bioluminescence-based Imaging and Photodynamic Thementioning

confidence: 99%

Nanoparticles of Conjugated Molecules and Polymers for Biomedical Applications

Seo

Lee

Cho

et al. 2015

Advances in Polymer Science

View full text Add to dashboard Cite

Semiconducting organic materials based on π-conjugated molecules or polymers have recently received considerable attention for their use as imaging and therapeutic agents for biomedical applications. Because π-conjugated materials exhibit desirable characteristics such as high brightness, photostability, emission tunability, and low toxicity, they are an attractive alternative to conventional fluorophores. In this review, the recent development of π-conjugated molecular nanoparticles for in vitro and in vivo biomedical applications is discussed.

show abstract

Bioluminescence resonance energy transfer using luciferase-immobilized quantum dots for self-illuminated photodynamic therapy

Cited by 144 publications

References 41 publications

Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications

Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications

Cerenkov Radiation Induced Photodynamic Therapy Using Chlorin e6-Loaded Hollow Mesoporous Silica Nanoparticles

Nanoparticles of Conjugated Molecules and Polymers for Biomedical Applications

Contact Info

Product

Resources

About