Biology, Physics and Genetics of Intracranial Aneurysm Formation: A Review

Ćmiel-Smorzyk, K.; Ładziński, Piotr; Kaspera, Wojciech

doi:10.1055/a-1994-8560

Cited by 3 publications

(2 citation statements)

References 166 publications

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“…IAs are persistent, localized dilatations of the arterial wall that are found in approximately 3% of the general population. The most severe complication of IAs is rupture which results in devastating consequences such as SAH and brain damage with serious neurological sequelae [1]. Jiang P. et all.…”

Section: Background and Importancementioning

confidence: 99%

Rapid Growth Progression of an Intracranial Internal Carotid Artery Aneurysm in a Patient with Multiple Inflammatory/Autoimmune Diseases Treated with a Flow Diverter

2023

J Surg

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Background and Importance. Unruptured supraclinoid aneurysms can be treated by surgery or endovascular therapy, but, when individualizing each patient, the associated comorbidities must be considered to select the best approach, follow-up control studies and treatment.Clinical Presentation: Sudden oppressive headache in the frontal-orbital and right retroocular region. Conclusion:Given the demonstration of an aneurysmal volumetric growth of 25% in 10 months, we consider that the risk of rupture of an unruptured aneurysms in patients with inflammatory and autoimmune comorbidities is higher than in patients outside of this context. We suggest carrying out a control study at least every 6 months to assess the evolution of the aneurysm and reconsider the possibility of endovascular treatment, with the placement of a flow diverter being an appropriate therapeutic option for its management.

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Section: Background and Importancementioning

confidence: 99%

Rapid Growth Progression of an Intracranial Internal Carotid Artery Aneurysm in a Patient with Multiple Inflammatory/Autoimmune Diseases Treated with a Flow Diverter

2023

J Surg

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“…Gut flora has been found to assume a part in cardiovascular diseases such as atherosclerosis and hypertension [ 5 , 6 ]. Hypertension and other related factors have long been reported to be significantly associated with intracranial aneurysms [ 7 ]. Therefore, we can speculate that intestinal dysbiosis may increase the risk of intracranial aneurysm through these high-risk factors for intracranial aneurysm.…”

Section: Introductionmentioning

confidence: 99%

Association of gut microbiome with risk of intracranial aneurysm: a mendelian randomization study

Zhang

Mao

et al. 2023

BMC Neurol

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Objective To investigate the potential causal link between genetic variants associated with gut microbiome and risk of intracranial aneurysm (IA) using two-sample mendelian randomization (MR). Methods We performed two sets of MR analyses. At first, we selected the genome-wide statistical significant(P < 5 × 10–8) single nucleotide polymorphisms (SNPs) as instrumental variables (IVs). Then, we selected the locus-wide significant (P < 1 × 10–5) SNPs as IVs for the other set of analyses to obtain more comprehensive conclusions. Gut microbiome genetic association estimates were derived from a genome-wide association study (GWAS) of 18,473 individuals. Summary-level statistics for IA were obtained from 79,429 individuals, which included 7,495 cases and 71,934 controls. Results On the basis of locus-wide significance level, inverse variance weighted(IVW) showed that Clostridia [(odds ratio (OR): 2.60; 95% confidence interval (CI): 1.00—6.72, P = 0.049)], Adlercreutzia (OR: 1.81; 95% CI: 1.10—2.99, P = 0.021) and Victivallis (OR: 1.38; 95% CI: 1.01—1.88, P = 0.044) were positively related with the risk of unruptured intracranial aneurysm(UIA); Weighted median results of MR showed Oscillospira (OR: 0.37; 95% CI: 0.17—0.84, P = 0.018) was negatively with the risk of UIA and Sutterella (OR: 1.84; 95% CI: 1.04—3.23, P = 0.035) was positively related with the risk of UIA; MR-Egger method analysis indicated that Paraprevotella (OR: 0.32; 95% CI: 0.13—0.80, P = 0.035) was negatively with the risk of UIA and Rhodospirillaceae (OR: 13.39; 95% CI: 1.44—124.47, P = 0.048) was positively related with the risk of UIA. The results suggest that Streptococcus (OR: 5.19; 95% CI: 1.25—21.56; P = 0.024) and Peptostreptococcaceae (OR: 4.92; 95% CI: 1.32—18.32; P = 0.018) may increase the risk of UIA according to genome-wide statistical significance thresholds. Conclusion This MR analysis indicates that there exists a beneficial or detrimental causal effect of gut microbiota composition on IAs.

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Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023

Chen,

Luo,

et al. 2024

World J Clin Cases

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BACKGROUND Intracranial aneurysms (IAs) pose significant health risks, attributable to their potential for sudden rupture, which can result in severe outcomes such as stroke and death. Despite extensive research, the variability of aneurysm behavior, with some remaining stable for years while others rupture unexpectedly, remains poorly understood. AIM To employ bibliometric analysis to map the research landscape concerning risk factors associated with IAs rupture. METHODS A systematic literature review of publications from 2004 to 2023 was conducted, analyzing 3804 documents from the Web of Science Core Collection database, with a focus on full-text articles and reviews in English. The analysis encompassed citation and co-citation networks, keyword bursts, and temporal trends to delineate the evolution of research themes and collaboration patterns. Advanced software tools, CiteSpace and VOSviewer, were utilized for comprehensive data visualization and trend analysis. RESULTS Analysis uncovered a total of 3804 publications on IA rupture risk factors between 2006 and 2023. Research interest surged after 2013, peaking in 2023. The United States led with 28.97% of publications, garnering 37706 citations. Notable United States-China collaborations were observed. Capital Medical University produced 184 publications, while Utrecht University boasted a citation average of 69.62 per publication. “World Neurosurgery ” published the most papers, contrasting with “Stroke ”, the most cited journal. The PHASES score from “Lancet Neurology ” emerged as a vital rupture risk prediction tool. Early research favored endovascular therapy, transitioning to magnetic resonance imaging and flow diverters. “Subarachnoid hemorrhage ” stood out as a recurrent keyword. CONCLUSION This study assesses global IA research trends and highlights crucial gaps, guiding future investigations to improve preventive and therapeutic approaches.

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Biology, Physics and Genetics of Intracranial Aneurysm Formation: A Review

Cited by 3 publications

References 166 publications

Rapid Growth Progression of an Intracranial Internal Carotid Artery Aneurysm in a Patient with Multiple Inflammatory/Autoimmune Diseases Treated with a Flow Diverter

Rapid Growth Progression of an Intracranial Internal Carotid Artery Aneurysm in a Patient with Multiple Inflammatory/Autoimmune Diseases Treated with a Flow Diverter

Association of gut microbiome with risk of intracranial aneurysm: a mendelian randomization study

Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023

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