Biology of the Cementum

Gottlieb, B

doi:10.1902/jop.1942.13.1.13

Cited by 55 publications

(16 citation statements)

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“…An association between enamel and cementum formation is compatible with the fact that coronal cementum is a normal structure on the enamel surface in a variety of rodents and Herbivora such as elephants, sheep, cows, rabbits and guinea-pigs (Gottlieb 1942, Hunt 1959, Weinreb & Sharav 1964, Listgarten 1968, Ainamo 1970, Schroeder 1986. There are no enclosed cells in areas where the cementum is thin, but in areas with a thick layer of cementum, there are enclosed cells, which appear to be both of epithelial and mesenchymal origin.…”

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confidence: 64%

Enamel matrix, cementum development and regeneration

Hammarström

1997

J Clinic Periodontology

652

633

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Studies during the last 20 years have indicated that enamel-related proteins are involved in the formation of cementum. In the present article, this relation is further explored. Attention is called to the fact that coronal acellular extrinsic fiber cementum is formed on the enamel surface in a number of species. The composition of the enamel matrix proteins and the expression of these proteins during root formation are briefly reviewed. The dominating constituent of the enamel matrix, amelogenin, is shown by means of immunohistochemistry to be expressed in human teeth during root formation. Amelogenin was also found to be present in Tomes' granular layer of human teeth. When mesenchymal cells of the dental follicle were exposed to the enamel matrix a non-cellular hard tissue matrix was formed at the enamel surface. Application of porcine enamel matrix in experimental cavities in the roots of incisors of monkeys induced formation of acellular cementum that was well attached to the dentin. In control cavities without enamel matrix, a cellular, poorly attached hard tissue was formed. The present studies provide additional support to the idea that enamel matrix proteins are involved in the formation of acellular cementum and also that they have the potential to induce regeneration of the same type of cementum.

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confidence: 64%

Enamel matrix, cementum development and regeneration

Hammarström

1997

J Clinic Periodontology

652

633

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“…The idea of following nature's strategies to regenerate periodontal tissues goes back to Bernhard Gottlieb, who almost 6 decades ago suggested that ''if these ideas about the biology of the cementum are correct, it is then our task to find out just how nature provides for continuous cementum deposition, and having done so, to imitate the procedure'' [9]. Another milestone in the science of periodontal regeneration was the work of Tony Melcher, who proposed that the PDL contains the progenitors for the regeneration of all 3 tissues, PDL, alveolar bone, and root cementum [10].…”

Section: Introductionmentioning

confidence: 99%

Successful Periodontal Ligament Regeneration by Periodontal Progenitor Preseeding on Natural Tooth Root Surfaces

Dangaria

Ito

Diekwisch

2011

Stem Cells and Development

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“…The specified intermediate, green‐staining layer seen in Fig. 5 may be either mantle dentine or the intermediate cementum as described by Hopewell‐Smith (1920) and Gottlieb (1942). Mantle dentine is the first‐formed dentine and forms a layer approximately 150 μm that is less mineralized than underlying dentine.…”

Section: Discussionmentioning

confidence: 92%