Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity

Koupenova, Milka; Ravid, Katya

doi:10.3389/fphar.2018.00037

Cited by 40 publications

(32 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The P2Y13 and P2Y14 receptors are recent P2Y receptors identified and novel members of the Gi-coupled P2Y receptor family. Although both the P2Y13 and P2Y14 receptors present platelets, the contribution of these receptors to platelet functionality has not been established [ 6 , 7 , 8 ]. Therefore, these receptors were initially underestimated.…”

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

“…The polymorphisms of these genes were reported in humans with yet unknown consequences [ 6 ]. The P2Y13 responds to ADP, just like the P2Y12 receptor [ 6 , 7 ]. The canonical signalling of P2Y13 and P2Y14 is coupled to a Gi receptor.…”

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

“…The canonical signalling of P2Y13 and P2Y14 is coupled to a Gi receptor. However, P2Y13 can also couple to different G proteins (Gs/Gq) and can trigger several intracellular pathways related to the activation of mitogen-activated protein kinases and the phosphatidylinositol 3-kinase [ 7 ]. P2Y13 plays a role in the regulation of cholesterol and glucose metabolism, bone homeostasis, and central nervous system function including pain transmission and neuroprotection [ 49 ].…”

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

“…There are two main types of receptors that mediate ADP-induced platelet activation: P2Y1 and P2Y12 receptors [ 5 ]. Platelets also express the P2Y13 and P2Y14 receptors, but the contribution of these receptors to platelet functionality has not been established [ 6 , 7 , 8 ]. In turn, the P2Y13 receptor is mostly involved into cholesterol and glucose metabolism, bone homeostasis, pain transmission, and neuroprotection in central nervous system, whereas its role in platelet activation has not yet been established [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Platelets also express the P2Y13 and P2Y14 receptors, but the contribution of these receptors to platelet functionality has not been established [ 6 , 7 , 8 ]. In turn, the P2Y13 receptor is mostly involved into cholesterol and glucose metabolism, bone homeostasis, pain transmission, and neuroprotection in central nervous system, whereas its role in platelet activation has not yet been established [ 6 , 7 ]. On the other hand, the P2Y14 receptor mediates vasoconstriction of the smooth muscle cells [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Role of P2Y Receptors in Platelet Extracellular Vesicle Release

Rogula

Eyileten

Postuła

et al. 2020

IJMS

View full text Add to dashboard Cite

Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation which may allow us to predict and/or diagnose developing coronary thrombosis before myocardial necrosis occurs. The P2Y1 and P2Y12 receptors play a key role in platelet activation and aggregation. Whereas the P2Y1 antagonists are at the preclinical stage, at present, the P2Y12 antagonists are the most effective treatment strategy to prevent stent thrombosis after percutaneous coronary intervention. Despite an increasing number of publications on PEVs, the mechanisms underlying their formation, including the role of purinergic receptors in this process, remain an active research field. Here, we outline the clinical relevance of PEVs in cardiovascular disease, summarize the role and downstream signalling of P2Y receptors in platelet activation, and discuss the available evidence regarding their role in PEV formation.

show abstract

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

Section: Other P2y Receptors: P2y13 and P2y14mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of P2Y Receptors in Platelet Extracellular Vesicle Release

Rogula

Eyileten

Postuła

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

The adenosinergic pathway in mesenchymal stem cell fate and functions

Galgaro

Beckenkamp

Nunnenkamp

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) play an important role in tissue homeostasis and damage repair through their ability to differentiate into cells of different tissues, trophic support, and immunomodulation. These properties made them attractive for clinical applications in regenerative medicine, immune disorders, and cell transplantation. However, despite multiple preclinical and clinical studies demonstrating beneficial effects of MSCs, their native identity and mechanisms of action remain inconclusive. Since its discovery, the CD73/ecto‐5′‐nucleotidase is known as a classic marker for MSCs, but its role goes far beyond a phenotypic characterization antigen. CD73 contributes to adenosine production, therefore, is an essential component of purinergic signaling, a pathway composed of different nucleotides and nucleosides, which concentrations are finely regulated by the ectoenzymes and receptors. Thus, purinergic signaling controls pathophysiological functions such as proliferation, migration, cell fate, and immune responses. Despite the remarkable progress already achieved in considering adenosinergic pathway as a therapeutic target in different pathologies, its role is not fully explored in the context of the therapeutic functions of MSCs. Therefore, in this review, we provide an overview of the role of CD73 and adenosine‐mediated signaling in the functions ascribed to MSCs, such as homing and proliferation, cell differentiation, and immunomodulation. Additionally, we will discuss the pathophysiological role of MSCs, via CD73 and adenosine, in different diseases, as well as in tumor development and progression. A better understanding of the adenosinergic pathway in the regulation of MSCs functions will help to provide improved therapeutic strategies applicable in regenerative medicine.

show abstract