Biology of Non-Hodgkin’s Lymphoma

Knowles, Daniel M.

doi:10.1007/978-1-4615-1601-9_6

Cited by 5 publications

(2 citation statements)

References 180 publications

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“…4,5 A hallmark of PEL is its association with human herpesvirus type 8 (HHV-8), although Epstein-Barr virus (EBV) sequences are usually detected in malignant cells. 6,7 PELs rarely express T-or B-cell surface antigens but are almost always genotypically B-cell lymphomas. 8 The pathogenesis of PEL is unclear; however, a number of genes encoded by HHV-8 with antiapoptotic or transforming potential have been identified.…”

Section: Introductionmentioning

confidence: 99%

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Ghosh

Wood

Boise

et al. 2003

Blood

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The survival of viral mediated lymphomas depends upon constitutive nuclear factor kappa B (NF-B) activity. AIDS-related human herpesvirus type 8-associated primary effusion lymphoma (PEL) responds poorly to chemotherapy and is almost invariably fatal. We have previously demonstrated that the antiviral combination of interferon alpha (IFN-␣) and azidothymidine (AZT) induces apoptosis in PEL cell lines. We therefore used these agents as therapy for an AIDS patient with PEL.

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Section: Introductionmentioning

confidence: 99%

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Ghosh

Wood

Boise

et al. 2003

Blood

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“… 82 , 83 Further reports of high rates of NHL occurring in patients with AIDS followed. 83 – 85 Burkitt lymphoma was the most common type of AIDS-related NHL, 86 and many AIDS-related NHL cases are EBV positive. 87 In the early 1980s, previous treatment experience with endemic BL gave clinicians a starting point for treating AIDS-related BL—although unfortunately AIDS-related BL does not share endemic’s BL sensitivity to chemotherapy.…”

Section: Impact Of Ebv and Htlv-1mentioning

confidence: 99%

Viral Causes of Lymphoma: The History of Epstein-Barr Virus and Human T-Lymphotropic Virus 1

Esau

2017

Virology�(Auckl)

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In 1964, Epstein, Barr, and Achong published a report outlining their discovery of viral particles in lymphoblasts isolated from a patient with Burkitt lymphoma. The Epstein-Barr virus (EBV) was the first human cancer virus to be described, and its discovery paved the way for further investigations into the oncogenic potential of viruses. In the decades following the discovery of EBV, multinational research efforts led to the discovery of further viral causes of various human cancers. Lymphomas are perhaps the cancer type that is most closely associated with oncogenic viruses: infection with EBV, human T-lymphotropic virus 1 (HTLV-1), human immunodeficiency virus (HIV), Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, and hepatitis C virus have all been associated with lymphomagenesis. Lymphomas have also played an important role in the history of oncoviruses, as both the first human oncovirus (EBV) and the first human retrovirus (HTLV-1) were discovered through isolates taken from patients with unique lymphoma syndromes. The history of the discovery of these 2 key oncoviruses is presented here, and their impact on further medical research, using the specific example of HIV research, is briefly discussed.

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AIDS and Associated Malignancies

Wood

Harrington

2008

DNA Tumor Viruses

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Biology of Non-Hodgkin’s Lymphoma

Cited by 5 publications

References 180 publications

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Viral Causes of Lymphoma: The History of Epstein-Barr Virus and Human T-Lymphotropic Virus 1

AIDS and Associated Malignancies

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