Biology of myelodysplastic syndromes

Yoshida, Yataro

doi:10.1002/stem.5530050502

Cited by 17 publications

(3 citation statements)

References 135 publications

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“…Several reports describe the dysregulation of cellular and humoral immunity. In particular, abnormal T-cell responses to antigen presentation and abnormal B-cell and T-cell interactions in MDS may be important in the pathogenesis of immune dysregulation leading to the development of an autoimmune phenomenon10-12). Alternatively, autoimmune manifestations may precede the onset of MDS.…”

Section: Discussionmentioning

confidence: 99%

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome

Choi

Ahn

Park

et al. 2005

Korean J Intern Med

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Myelodysplastic syndrome (MDS) is a heterogenous group of stem cell disorders usually characterized by progressive refractory cytopenias, which could progress to acute myeloid leukemia. MDS may be associated with a wide spectrum of skin lesions, including neoplastic cell infiltration, Sweet's syndrome, pyoderma gangrenosum, erythema elevatum diutinum, vasculitis, and panniculitis. However, erythema nodosum is rarely associated with MDS. Unusual rheumatologic manifestations in patients with MDS also have been reported, which range from asymptomatic serological abnormalities to classic connective tissue disorders such as Sjogren's syndrome, relapsing polychondritis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease. However, concurrent erythema nodosum and serositis has rarely been reported. We describe a case of MDS with erythema nodosum and immune-mediated pericardial effusion in a 34-year-old woman.

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Section: Discussionmentioning

confidence: 99%

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome

Choi

Ahn

Park

et al. 2005

Korean J Intern Med

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“…Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cells associated with ineffective and dysplastic hematopoiesis. An abnormality in megakaryocyte‐platelet lineage cells reflects a defect in the regulatory systems of megakaryocyte development and platelet formation (10). In MDS, mpl mRNA expression is reportedly increased in about half of patients with refractory anemia with excess of blasts (RAEB), RAEB in transformation and chronic myelomonocytic leukemia, but not in patients with refractory anemia (RA) or RA with ringed sideroblasts, and mpl expression is associated with CD34 + and CD41 + and with the presence of dysmegakaryopoiesis in RAEB and RAEB in transformation (11).…”

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confidence: 99%

Decreased amount of mpl and reduced expression of glycoprotein IIb/IIIa and glycoprotein Ib on platelets from patients with refractory anemia: analysis by a non‐isotopic quantitative ligand binding assay and immunofluorescence

Izumi

Takeshita

Shinjo

et al. 2001

European J of Haematology

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Using a non-isotopic ligand binding assay and immunofluorescence, we examined the amount of mpl, glycoprotein IIb/IIIa (gpIIb/IIIa) and glycoprotein Ib (gpIb) on platelets from healthy volunteers and patients with refractory anemia (RA). For the analysis of mpl expression, we applied both a non-isotopic ligand binding assay and immunofluorescence using anti-mpl monoclonal antibody, and compared the results from both methods. The non-isotopic ligand binding assay has been developed in our laboratory and is suitable for the quantitative analysis of a small amount of cytokine receptors such as mpl on platelets. In platelets from patients with RA, the amount of mpl expressed by the D value was 0.05+/-0.03 (mean+/-standard deviation), and was significantly lower than that in healthy volunteers (0.15+/-0.05, p<0.0001). The mean fluorescence intensities (MFI) of gpIIb/IIIa and gpIb on platelets from RA patients were 28.8+/-8.8 and 20.8+/-7.7, respectively, and were significantly lower than those on normal subjects (93.2+/-22.6 and 67.4+/-9.1, p<0.0001 and p<0.0001, respectively). There was a good correlation between the amount of mpl and the MFI of gpIIb/IIIa (p=0.794, p<0.0001) or gpIb (p=0.774, p<0.0001), and between those of gpIIb/IIIa and gpIb (p=0.728, p<0.0001). We demonstrated a decreased amount of mpl as well as a reduced expression of gpIIb/IIIa and gpIb on platelets from RA patients.

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“…Myelodysplastic syndrome (MDS) is a heterogeneous group of haemopoietic disorders characterized by cytopenias (Jacobs, 1985: Yoshida, 1987. It has been reported that MDS-derived inhibitory macrophage (Ohmori et al, 1990), MDS-monocyte-derived lipid containing macrophage (MDLM) (Ohmori et al, 1992) and MDS derived mononuclear cells (Fukuoka & Fujita, 1987;Cukrova et al, 1989;Cukrova & Neuwirtova, 1990) inhibit the growth of normal CFU-GM colony formation.…”

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MDS‐macrophage derived inhibitory activity on myelopoiesis of MDS abnormal clones

Ohmori

Yamagishi

et al. 1993

Br J Haematol

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We studied the effect of myelodysplastic syndrome (MDS)-derived adherent cells on colony formation of granulocyte-macrophage progenitors (CFU-GM) in both normal and MDS bone marrow cells. MDS-adherent cells suppressed the growth of normal CFU-GM colony formation. Antibodies against ferritin almost totally neutralized the haematopoietic inhibitory activity. Antibody against gamma-interferon (gamma-IFN) did not have such effect. By cytogenetic analysis using G-staining method, MDS-derived CFU-GM colony showed abnormal clones. MDS have been recognized to be a mosaic of normal and abnormal clones. MDS-macrophages suppressed the growth of progenitor cells derived from normal clones by soluble factors, but did not suppress the growth of those from abnormal clones. It is suggested that progenitor cells derived from abnormal clones are freed from the negative myelopoietic regulator that may be related to the progress of leukaemia.

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Biology of myelodysplastic syndromes

Cited by 17 publications

References 135 publications

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome

Decreased amount of mpl and reduced expression of glycoprotein IIb/IIIa and glycoprotein Ib on platelets from patients with refractory anemia: analysis by a non‐isotopic quantitative ligand binding assay and immunofluorescence

MDS‐macrophage derived inhibitory activity on myelopoiesis of MDS abnormal clones

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