Biology of Metastasizing Ameloblastoma

Metastasizing ameloblastoma

“…6 Articles in the literature concerning malignant, metastasizing ameloblastoma do not address the therapy of metastasis. The ideal method for dealing with metastasis from ameloblastoma is to prevent it by adequately resecting CANCER August I 1989 Vol.…”

Metastasizing ameloblastoma

“…The median survival time after the appearance of metastases ranges from 3 months to 5 years 5 , with the longest reported survival time being 25 years 5,8 . Most malignant amelolastomas are of the plexiform histopathologic type, but their histologic and cytologic features are not significantly different from those of the non-metastatic type 7,9 . There are no morphological criteria to predict the biological behaviour of ameloblastomas with respect to their potential for metastatic spread 7 .…”

“…The interval between diagnosis of the primary and development of a metastasis is generally long, with an average of 10-12 years 4,7 .…”

Malignant odontogenic tumors: an overview

“…Confusion may also arise through the use of the term atypical ameloblastomas to denote lesions with fatal outcome for various reasons, either metastasis, histologic atypia, or relentless local spread [3]. Metastatic deposits of malignant ameloblastomas mostly are seen in the lung [24,33,36,61,67] but have also been reported at a lot of other sites. Their occurrence at sites other than the lung refutes the idea that metastasis of ameloblastoma does not mean real metastatic spread but outgrowth of aspirated tumor fragments.…”