Biology of Lipid Rafts: Introduction to the Thematic Review Series

Sviridov, Dmitri; Miller, Yury I.

doi:10.1194/jlr.in119000330

Cited by 14 publications

(10 citation statements)

References 20 publications

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“…FOXO1). However, it also potentiating OGT activity through tyrosine phosphorylation ( 323 ) and directs its translocation to cell membranes, particularly lipid rafts ( 92 ) that play a significant role in protein complex assembly and signal transduction [for review ( 324 )]. In a detailed characterization of feeding-related O -GlcNAc regulatory patterns in the fly body, Liu et al demonstrate how both eating and circadian rhythmicity drive transient elevations in pre-prandial Ogt and fasting Oga ( 64 ).…”

Section: O- Glcnacylation In Lipid Storage and Releasementioning

confidence: 99%

A nexus of lipid and O-Glcnac metabolism in physiology and disease

Lockridge

Hanover

2022

Front. Endocrinol.

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Although traditionally considered a glucose metabolism-associated modification, the O-linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids and is required to maintain lipid homeostasis. The enzymes of O-GlcNAc cycling have molecular properties consistent with those expected of broad-spectrum environmental sensors. By direct protein-protein interactions and catalytic modification, O-GlcNAc cycling enzymes may provide both acute and long-term adaptation to stress and other environmental stimuli such as nutrient availability. Depending on the cell type, hyperlipidemia potentiates or depresses O-GlcNAc levels, sometimes biphasically, through a diversity of unique mechanisms that target UDP-GlcNAc synthesis and the availability, activity and substrate selectivity of the glycosylation enzymes, O-GlcNAc Transferase (OGT) and O-GlcNAcase (OGA). At the same time, OGT activity in multiple tissues has been implicated in the homeostatic regulation of systemic lipid uptake, storage and release. Hyperlipidemic patterns of O-GlcNAcylation in these cells are consistent with both transient physiological adaptation and feedback uninhibited obesogenic and metabolic dysregulation. In this review, we summarize the numerous interconnections between lipid and O-GlcNAc metabolism. These links provide insights into how the O-GlcNAc regulatory system may contribute to lipid-associated diseases including obesity and metabolic syndrome.

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Section: O- Glcnacylation In Lipid Storage and Releasementioning

confidence: 99%

A nexus of lipid and O-Glcnac metabolism in physiology and disease

Lockridge

Hanover

2022

Front. Endocrinol.

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“…As discussed in the previous section, broader application of this concept, e.g. by including reprogramming of lipid metabolism, allows to hypothesize that epigenetic modifications of genes for ABC transporters or sphingomyelin metabolism would result in chronic elevation of the abundance and modified properties of the lipid rafts, a key pathogenic element in many cardiovascular, metabolic and neurological disorders (63)(64)(65)(66). Consistent with this idea, monocytes from virologically suppressed HIV-infected individuals were shown to have decreased expression of ABCA1 and reduced cholesterol efflux (67).…”

Section: Trained Immunity and Hiv Co-morbiditiesmentioning

confidence: 99%

Trained Immunity and HIV Infection

2022

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Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light. It was found that the key cells responsible for heterologous protection are innate immune cells such as natural killer cells (NKs), dendritic cells, and monocytes/macrophages. These cells are ‘primed’ by initial infection, allowing them to provide enhanced response to subsequent infection by the same or unrelated agent. This phenomenon of innate immune memory was termed ‘trained immunity’. The proposed mechanism for trained immunity involves activation by the first stimulus of metabolic pathways that lead to epigenetic changes, which maintain the cell in a “trained” state, allowing enhanced responses to a subsequent stimulus. Innate immune memory can lead either to enhanced responses or to suppression of subsequent responses (‘tolerance’), depending on the strength and length of the initial stimulation of the immune cells. In the context of HIV infection, innate memory induced by infection is not well understood. In this Hypothesis and Theory article, we discuss evidence for HIV-induced trained immunity in human monocytes, its possible mechanisms, and implications for HIV-associated co-morbidities.

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“…[197] For instance, lipid rafts are highly controversial microdomains found in the PM and are considered to be organized "islands" of different polarities and represent heterogeneities in the fluid membrane. [198]…”

Section: Plasma Membrane Selective Stainingmentioning

confidence: 99%

Fluorescent Benzothiadiazole Derivatives as Fluorescence Imaging Dyes: A Decade of New Generation Probes

Neto

Corrêa

Spencer

2021

Chemistry A European J

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The current review describes advances in the use of fluorescent 2,1,3‐benzothiadiazole (BTD) derivatives after nearly one decade since the first description of bioimaging experiments using this class of fluorogenic dyes. The review describes the use of BTD‐containing fluorophores applied as, inter alia, bioprobes for imaging cell nuclei, mitochondria, lipid droplets, sensors, markers for proteins and related events, biological processes and activities, lysosomes, plasma membranes, multicellular models, and animals. A number of physicochemical and photophysical properties commonly observed for BTD fluorogenic structures are also described.

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Biology of Lipid Rafts: Introduction to the Thematic Review Series

Cited by 14 publications

References 20 publications

A nexus of lipid and O-Glcnac metabolism in physiology and disease

A nexus of lipid and O-Glcnac metabolism in physiology and disease

Trained Immunity and HIV Infection

Fluorescent Benzothiadiazole Derivatives as Fluorescence Imaging Dyes: A Decade of New Generation Probes

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