Biology of Hypothalamic Neurons and Pituitary Cells

Pantić, V.

doi:10.1016/s0074-7696(08)62105-1

Cited by 21 publications

(19 citation statements)

References 191 publications

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“…Lov ren et al (10) and Sekuli} et al (12) have reported that EDP application, in the critical neonatal period, has stimulatory effects on the absolute pituitary weight and glycoprotein-producing cells morphometric parameters. Also, it was demonstrated that EDP treatment increases the Brought to you by | MIT Libraries Authenticated Download Date | 5/10/18 5:37 PM number of chromophobes, PRL (19,20) and LH cells (11), which confirms our results.…”

Section: Resultssupporting

confidence: 90%

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Milošević¹,

Todorović²,

Veličković³

et al. 2012

Journal of Medical Biochemistry

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Summary: Estradiol and human chorionic gonadotropin (hCG) are very important in controlling the secretory activity of hormone producing cells in the female rat pituitary glands. The aim of the present study was to examine the morphometric parameters of immunohistochemically la be led ACTH cells in juvenile (16th day) female rat pituitaries after treatment with five doses of estradiol dipropionate (EDP) and two doses of hCG during the neonatal period of life. The controls were treated on the same schedule with an equivalent volume of vehicle. All animals were sacrificed 24 h after the last treatment. ACTH-producing cells were stu died using the peroxidase-antiperoxidase immunohistochemical procedure. The absolute and relative pituitary weights were increased (p<0.05) only in the EDP treated group by 120.0% and by 121.1% respectively, in comparison with the controls. In this group, the volume of ACTH cells, volume of their nuclei and vo lume density were significantly decreased (p<0.05) by 6.4%, 33.3% and 46.2% respectively, compared to the corresponding controls. After treatment with hCG, there were no significant (p>0.05) changes neither in the volume of ACTH cells nor in the volume of their nuclei, in comparison with the controls. On the basis of the results obtained in our study, it can be concluded that EDP, injected into female rats during the neonatal period of life, has an inhibitory effect on the immunohistomorphometric parameters of ACTH cells, but such an effect is not clearly expressed after treatment with hCG. Keywords: ACTH cells, EDP, hCG, female ratsKratak sadr`aj: Estradiol i humani horionski gonadotropin (hCG) veoma su va`ni u kontroli sekretorne aktivnosti }elija hipofize koje proizvode hormone. Cilj ove studije je bio ispitati morfometrijske parametre imunohistohemijski obele`enih ACTH }elija hipofize `enki pacova, u juvenilnom periodu (16. dan), nakon tretmana sa pet doza estradiol-dipropionata (EDP) ili dve doze humanog horionskog gonadotropina (hCG). Kontrole su bile tretirane na istovetan na~in sa odgovaraju}om koli~inom rastvara~a. Svè ivotinje su bile `rtvovane 24 h nakon poslednjeg tretmana. ACTH }elije su bile imunohistohemijski obele`ene metodom peroksidaza-antiperoksidaza (PAP). Dobijeni rezultati ukazuju na zna~ajno pove}anje (p<0,05) apsolutne i relativne mase hipofize za 120% i 121,1% kod `enki tretiranih sa EDP u odnosu na kontrolu. U ovoj grupi `enki pacova volumen ACTH }elija i njihovih jedara, kao i njihova volumenska gustina su bili zna~ajno smanjeni (p<0,05) za 6,4%, 33,3% i 46,2% u pore|enju sa kontrolom. Nakon tretmana hCG-om, volumen ACTH }elija, kao i volumen njihovih jedara, nisu bili zna~ajno (p>0,05) promenjeni u odnosu na kontrolu. Na osnovu dobijenih rezultata moemo zaklju~iti da EDP, injeciran `enkama pacova tokom neonatalnog perioda `ivota, ima inhibitorni efekat na imuno histomorfometrijske parametre ACTH }e lija, {to nije tako jasno izra`eno nakon tretmana hCG-om.

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Section: Resultssupporting

confidence: 90%

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Milošević¹,

Todorović²,

Veličković³

et al. 2012

Journal of Medical Biochemistry

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“…We observed that the cellular and nuclear volumes of the PRL cells, and their relative volume density in this animal model of menopause Unauthenticated Download Date | 5/11/18 9:13 AM (35,45). Finally, estradiol replacement represents the classical therapeutic approach in the prevention of menopausal problems, although manifesting some risks (12)(13)(14).…”

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 70%

“…Lysosomes that were occasionally observed in GH cells of acyclic female rats (4,28,32) demonstrated that the GH secretion declines with ageing and the GH-mRNA content decreases due to diminished transcriptional activity of the adequate genes (33). The serum GH level decreased in middle-aged female rats, which is explained by the increased release of somatostatin and the decreased release of growth hormone-releasing hormone (GHRH) from the hypothalamus (34), as well as with a reduced pituitary responsiveness to GHRH stimulation (35). In young female rats, the blood GH levels were significantly higher than those of middleaged females, whereas the amplitude of GH pulsatile release was lower in the middle-aged rats compared with the young rats (34).…”

Section: The Effects Of Estradiol Application On Pituitary Hormone-prmentioning

confidence: 99%

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Milošević

Ajdžanović

2014

Serbian Journal of Experimental and Clinical Research

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Female ageing represents the biological process of structural and functional changes in endocrine cells and tissues, as well as in pituitary hormone-producing cells. In addition to the hypothalamic releasing hormones, estradiol plays a signifi cant role in the regulation SAŽETAK Starenje kod ženskog pola je biološki proces tokom kojeg dolazi do promena u strukturi i funkciji endokrinih ćelija i tkiva, a posebnu osetljivost ispoljavaju hipofi zne hormonprodukujuće ć elije. Pored oslobađajućih hormona hipotalamusa i estradiol ostvaruje zapaženu ulogu u regulaciji sinteze i sekrecije hipofi znih hormona, a još uvek se koristi u terapiji menopauzalnih tegoba. Efekti starenja ili ovarijektomije, kao i primene sintetskog estradiola pod tim okolnostima su ispitivani na hormon-produkujućim ć elijama hipofi ze ženki pacova srednjeg doba (animalni modeli menopauze) i to: gonadotropima (FSH i LH), tirotropima (TSH), somatotropima (GH), mamotropima (PRL) i kortikotropima (ACTH

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“…Namely, besides the daily-based pulsatile GH secretion in young individuals of both genders (3), maturing females express the luteinizing hormone (LH) increase coinciding decline in circulating GH/IGF1 levels (4, 5), while high circulating estradiol is followed with GH elevation (6,7,8). Generally, it is well founded that estradiol has stimulatory effect on the pituitary weight of female rats when applied in critical neonatal period of life (9,10,11,12) as well as that increases the number of chromophobes, prolactin (PRL), luteinizing hormone-(LH) and follicle stimulating hormone-(FSH) producing cells (9,13,14,15,16). On the other hand, immunohistomorphometric features of pituitary adrenocorticotropic (ACTH) cells of infant and peripubertal female rats appear decreased upon application of estradiol (11,12).…”

Section: Introductionmentioning

confidence: 99%

Immunohistomorphometric Characteristics Of Pituitary GH Cells In Infant And Peripubertal Female Rats After Treatment With Estradiol Or Human Chorionic Gonadotropin

Ristić

Ajdžanović

Trifunović

et al. 2015

Serbian Journal of Experimental and Clinical Research

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Biology of Hypothalamic Neurons and Pituitary Cells

Cited by 21 publications

References 191 publications

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Immunohistomorphometric Features of ACTH Cells in Juvenile Rats after Treatment with Estradiol or Human Chorionic Gonadotropin

Pituitary Hormone-producing Cells After Estradiol Application in Rat Models of Menopause

Immunohistomorphometric Characteristics Of Pituitary GH Cells In Infant And Peripubertal Female Rats After Treatment With Estradiol Or Human Chorionic Gonadotropin

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