Biology of basal cell carcinoma (Part I)

Miller, Stanley J.

doi:10.1016/0190-9622(91)70001-i

Cited by 365 publications

(181 citation statements)

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“…Malignancies appear in adolescence proving fatal in the third decade [8,9]. Cutaneous cancers i.e., BCC and SCC are the commonest cancers universally, occurs in old age while in teenage XP patients [19,20]. BCC is currently the most common cutaneous cancer in humans [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Halkud

Shenoy

Naik

et al. 2014

Indian J Surg Oncol

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Multiple oculo-cutaneous malignancies are a common manifestation on sun-exposed facial areas in patients with Xeroderma pigmentosum (XP). Commonly seen are the basal cell carcinoma and the squamous cell carcinomas which manifest in the early first decade in contrast to fifth and sixth decade in the general population. XP manifests as photosensitivity, hyperpigmentation, premature skin aging and malignant changes like squamous cell carcinoma, basal cell carcinoma, fibrosarcoma and rarely malignant melanoma as well as internal malignancies. We report 11 cases of Xeroderma pigmentosa managed in our institute which included sex males and five females. All had photosensitivity, hyperpigmentation and consanguinity with facial malignant lesions like SCC and BCC. Ocular signs of photophobia and excessive lacrimation was seen in all the cases while blurring of vision due to corneal clouding, corneal injection, pterygium and limbal SCC were seen in 5 cases. SCC of the lids were seen in 7 cases while BCC seen in 8 cases and limbal and conjunctival SCC seen in one case. All were managed with excision while one case of melanoma with neck secondaries needed radical neck dissection while the other orbital exenteration. Oculo-cutaneous malignancies occur in the sun exposed areas so patients are advised regular follow up with speciality care. Awareness about the rare condition and importance of early detection and prevention of UV rays induced skin damage should be propagated. The disease is ultimately fatal, life can be prolonged by simple preventive measures to minimize sun exposure and early detection of the skin lesions and management.

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Section: Discussionmentioning

confidence: 99%

“…Cutaneous cancers i.e., BCC and SCC are the commonest cancers universally, occurs in old age while in teenage XP patients [19,20]. BCC is currently the most common cutaneous cancer in humans [19,20]. Incidence ratio of BCC to SCC is 1.5 worldwide while males are affected 1.8 times more than females [21,22].…”

Section: Discussionmentioning

confidence: 99%

Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Halkud

Shenoy

Naik

et al. 2014

Indian J Surg Oncol

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“…The etiology is unknown but for vulvar BCC risk factors have been implicated. Millar et al [4] have identified immunosuppression caused by aging, chronic vulvovaginitis, radiotherapy and hormonal changes as factors that could significantly influence the basal cell degeneration leading to carcinoma. Barrett [3] noted the importance of mutations of the p53 gene in the pathogenesis of BCC in about 50% of cases; these factors that predispose to these gene mutations include advanced age, exposure to ionizing radiation, and chemicals (such as arsenic) inherited and chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Vulvar Basal Cell Carcinoma of a 40 Years Old Black Woman: About a Case and Literature Review

Horo¹,

Aka²,

Koffi³

et al. 2016

OJOG

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“…This has been attributed to the dependence of basal epithelioid cells on the appropriate underlying stroma without which individual cells cannot divide [2]. The rate of metastasis is reported to vary between 0.0028 in an outpatient clinic setting and 0.1 in a tertiary surgical center [3]. Local treatment by excision, cryotherapy, electrodessication and curettage, or radiation is most often curative.…”

Section: Discussionmentioning

confidence: 99%

“…Tumors greater than 10 cm in diameter are reported to have a 45% incidence of metastasis. Although several histologic patterns of BCC are recognized, it appears that no single subtype reliably predicts metastatic potential [3]. Perhaps the most important factor is patient neglect – often attributable to alcoholism, cognitive dysfunction or a reclusive lifestyle.…”

Section: Discussionmentioning

confidence: 99%