Biology and function of pericytes in the vascular microcirculation

Wu, Yuanhao; Fu, Jiaqi; Huang, Yuxia; Duan, Ruowang; Zhang, Wentian; Wang, Caihong; Wang, Shang; Zhao, Hui; Wang, Lan; Gao, Guosheng; Yuan, Ping

doi:10.1002/ame2.12334

Cited by 11 publications

(6 citation statements)

References 76 publications

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“…Abnormal structure and function of miniscule arteries and capillaries results in hypoperfusion of blood flow (Mourad and Levy, 2011;Struijker-Boudier and Heijnen, 2011;Wu et al, 2023). Studies have shown that sparse microcirculation may be one of the main causes of hypertension (Ciuffetti et al, 2003).…”

Section: Relationship Between Microcirculation-induced Hypertension A...mentioning

confidence: 99%

Microvascular rarefaction caused by the NOTCH signaling pathway is a key cause of TKI-apatinib-induced hypertension and cardiac damage

Wang,

Li,

et al. 2024

Front. Pharmacol.

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With the advancement of tumour-targeted therapy technology, the survival of cancer patients has continued to increase, and cardiovascular events have gradually become an important cause of death in cancer patients. This phenomenon occurs due to adverse cardiovascular reactions caused by the cardiovascular toxicity of antitumour therapy. Moreover, the increase in the proportion of elderly patients with cancer and cardiovascular diseases is due to the extension of life expectancy. Hypertension is the most common cardiovascular side effect of small molecule tyrosine kinase inhibitors (TKIs). The increase in blood pressure induced by TKIs and subsequent cardiovascular complications and events affect the survival and quality of life of patients and partly offset the benefits of antitumour therapy. Many studies have confirmed that in the pathogenesis of hypertension, arterioles and capillary thinness are involved in its occurrence and development. Our previous findings showing that apatinib causes microcirculation rarefaction of the superior mesenteric artery and impaired microvascular growth may inspire new therapeutic strategies for treating hypertension. Thus, by restoring microvascular development and branching patterns, total peripheral resistance and blood pressure are reduced. Therefore, exploring the key molecular targets of TKIs that inhibit the expression of angiogenic factors and elucidating the specific molecular mechanism involved are key scientific avenues for effectively promoting endothelial cell angiogenesis and achieving accurate repair of microcirculation injury in hypertension patients.

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Section: Relationship Between Microcirculation-induced Hypertension A...mentioning

confidence: 99%

Microvascular rarefaction caused by the NOTCH signaling pathway is a key cause of TKI-apatinib-induced hypertension and cardiac damage

Wang,

Li,

et al. 2024

Front. Pharmacol.

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“…Although ECs, which make up the innermost layer of blood vessels, can naturally form initial networks, the absence of pericyte recruitment causes these structures to rapidly deteriorate [ 33 , 123 ]. Pericytes have an important role to play in the regulation of vascular blood flow, regulation of the internal diameter of the vasculature, and vascular stabilization [ 124 , 125 ].…”

Section: Cell Source For Blood Capillary Formationmentioning

confidence: 99%

Technology for the formation of engineered microvascular network models and their biomedical applications

Li,

Shang,

Zeng

et al. 2024

Nano Convergence

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Tissue engineering and regenerative medicine have made great progress in recent decades, as the fields of bioengineering, materials science, and stem cell biology have converged, allowing tissue engineers to replicate the structure and function of various levels of the vascular tree. Nonetheless, the lack of a fully functional vascular system to efficiently supply oxygen and nutrients has hindered the clinical application of bioengineered tissues for transplantation. To investigate vascular biology, drug transport, disease progression, and vascularization of engineered tissues for regenerative medicine, we have analyzed different approaches for designing microvascular networks to create models. This review discusses recent advances in the field of microvascular tissue engineering, explores potential future challenges, and offers methodological recommendations.

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“…Pericytes are crucial for angiogenesis, influencing vessel stability by interacting with sprouting endothelial cells. They can also adjust capillary diameters, similar to smooth muscle cells, regulating microvessel blood flow [19].…”

Section: Angiogenesismentioning

confidence: 99%

“…They regulate the immune system in the central nervous system. Reduced CD4+ T-cells lead to decreased pericyte coverage, and retinal pericytes inhibit CD4+ T-cell activation [19].…”

Section: Impact On Immune Functionmentioning

confidence: 99%

The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

Issabekova,

Kudaibergen,

Sekenova

et al. 2023

Biomedicines

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Pericytes, as perivascular cells, are present in all vascularized organs and tissues, and they actively interact with endothelial cells in capillaries and microvessels. Their involvement includes functions like blood pressure regulation, tissue regeneration, and scarring. Studies have confirmed that pericytes play a crucial role in bone tissue regeneration through direct osteodifferentiation processes, paracrine actions, and vascularization. Recent preclinical and clinical experiments have shown that combining perivascular cells with osteogenic factors and tissue-engineered scaffolds can be therapeutically effective in restoring bone defects. This approach holds promise for addressing bone-related medical conditions. In this review, we have emphasized the characteristics of pericytes and their involvement in angiogenesis and osteogenesis. Furthermore, we have explored recent advancements in the use of pericytes in preclinical and clinical investigations, indicating their potential as a therapeutic resource in clinical applications.

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Biology and function of pericytes in the vascular microcirculation

Cited by 11 publications

References 76 publications

Microvascular rarefaction caused by the NOTCH signaling pathway is a key cause of TKI-apatinib-induced hypertension and cardiac damage

Microvascular rarefaction caused by the NOTCH signaling pathway is a key cause of TKI-apatinib-induced hypertension and cardiac damage

Technology for the formation of engineered microvascular network models and their biomedical applications

The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

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