Biology and Diseases of Rabbits

Kraus, Alan L.; Weisbroth, Steven H.; Flatt, Ronald E.; Brewer, Nathan

doi:10.1016/b978-0-12-263620-2.50014-8

Cited by 27 publications

(43 citation statements)

References 45 publications

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“…Wild and domestic rabbits are said to have a definite period of anestrus. 22 Therefore, it is certain that there is a significant change in sex hormone level in the rabbit. In this respect, the possibility of certain change in the receptor density or the receptor affinity to neurotransmitters still exists in the rabbit.…”

Section: Discussionmentioning

confidence: 99%

Histological and functional aspects of different regions of the rabbit vagina

et al. 2003

Int J Impot Res

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Relatively little data is available on regional differences in both morphological and functional studies of vaginal smooth muscle in the rabbit. Histological and in vitro strip studies were performed upon the vaginal walls of 10-week-old New Zealand White rabbits discriminately according to location (upper, middle or lower) and the type of muscle arrangement (longitudinal or circular). The contraction and relaxation responses of the vaginal smooth muscle were assessed. The upper and middle third of the vagina were histologically characterized by an abundance of smooth muscle, while the lower third was composed of numerous sinusoids scattered among smooth muscle bundles. The peak amplitudes of 60 mM KCl-induced contraction per tissue strip weight were regionally different (upper4middle4lower). Contractile responses induced by adrenergic agonists (epinephrine, norepinephrine, phenylephrine and isopreterenol) showed regional differences, and were mainly of a tonic nature in lower part and strong phasic in middle and upper vagina. Electrical field stimulation induced a prominent relaxation response in the lower third of the vagina precontracted with phenylephrine (5 lM). This relaxation response was partially inhibited by N-omega-nitro-L-arginine methyl ester (NAME, 43.3 7 6.9%, s.e.), a nitric oxide synthase inhibitor, and D-vasoactive intestinal peptide (VIP) (11.3 7 4.4%), a VIP receptor antagonist. The type of muscle arrangement did not affect the results. Our results demonstrated that rabbit vagina has regional difference, not only histologically but also functionally. The contractile response was induced in all regions of the rabbit vagina by sympathetic agonists, while the prominent nerve-mediated relaxation was identified in the lower third portion of the rabbit vagina. The nature of relaxation and contractile function of vagina awaits future investigation.

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Section: Discussionmentioning

confidence: 99%

Histological and functional aspects of different regions of the rabbit vagina

et al. 2003

Int J Impot Res

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“…It is not uncommon that the gradual development of fur balls leads to intestinal stasis and fatal rupture (Jackson 1991). Hair pulling and fur balls are seen more often in singly-caged than in group-housed rabbits (Kraus et al 1994, Vera Baumans 2004.…”

Section: Rabbitsmentioning

confidence: 99%

Hair pulling: a review

Reinhardt

2005

Lab Anim

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“…1979;Kaplan et at. 1983;Kraus et al 1984) were used, The results are given in Table 1 and are comparable to doses given intraperitoneally or orally (0.1-14 mmol/kg body weight) Mitchell et al 1971;Reid 1973;Kluwe et at. 1984;Rush et al 1984).…”

Section: Methodsmentioning

confidence: 97%

Species differences in short term toxicity from inhalation exposure to bromobenzene

Dahl¹,

Becher²,

Aarstad

et al. 1990

Arch Toxicol

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Lung, liver and kidney injury were studied in mice, rats and rabbits 48 h after termination of a 4 h inhalation exposure to bromobenzene vapour (250-3400 ppm). Light and electron microscopy of lung tissue revealed injury to Clara cells and adjacent epithelium in mouse bronchioli (bromobenzene concentration 250 ppm and 1000 ppm) and to Clara cells of rat bronchi and bronchioli (1000 ppm bromobenzene) and of rabbit bronchi (2500 ppm and 3400 ppm). Histological and clinicochemical indices of liver damage were found in the same animals, whereas kidney toxicity was observed in mice (two out of ten showed tubular necrosis and elevated concentration of plasma urea) and rats (all had elevated plasma concentrations of creatinine) exposed to 1000 ppm bromobenzene. Inhalation exposure thus produced less kidney injury than expected from previous studies with equimolar doses given intraperitoneally. The mouse was the most severely affected species, followed by the rat, and lastly the rabbit. The animal susceptibility could not be ranked according to the rate of 14C-bromobenzene covalent binding in lung or liver, but it was inversely related to the rate of N-demethylation of benzphetamine (indicative of P450IIB activity) in both lung and liver microsomal preparations. Differences in a P450 mediated detoxification could therefore be of importance in species variability to bromobenzene injury.

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Biology and Diseases of Rabbits

Cited by 27 publications

References 45 publications

Histological and functional aspects of different regions of the rabbit vagina

Histological and functional aspects of different regions of the rabbit vagina

Hair pulling: a review

Species differences in short term toxicity from inhalation exposure to bromobenzene

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