Biology and Diseases of Mice

Jacoby, Robert O.; Fox, James G.; Davisson, Muriel T.

doi:10.1016/b978-012263951-7/50006-5

Cited by 51 publications

(55 citation statements)

References 157 publications

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“…13,14). 56 Most S. aureus lesions are thought to be opportunistic and secondary to trauma. For example, penetration of hair fragments into the periodontal tissues occurs frequently in mice, especially those prone to excessive grooming that introduces Staphylococcus and other oropharyngeal flora deep in the soft tissues (Fig.…”

Section: Bacterial Agentsmentioning

confidence: 99%

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Of Mice and Microflora

et al. 2011

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The phenotype of genetically engineered mice is a combination of both genetic and environmental factors that include the microflora of the mouse. The impact a particular microbe has on a mouse reflects the host-microbe interaction within the context of the mouse genotype and environment. Although often considered a confounding variable, many host-microbe interactions have resulted in the generation of novel model systems and characterization of new microbial agents. Microbes associated with overt disease in mice have been the historical focus of the laboratory animal medical and pathology community and literature. The advent of genetic engineering and the complex of mouse models have revealed previously unknown or disregarded agents that now oblige the attention of the biomedical research community. The purpose of this article is to describe and illustrate how phenotypes can be affected by microflora by focusing on the infectious diseases present in genetically engineered mouse (GEM) colonies of our collective institutions and by reviewing important agents that are rarely seen in most research facilities today. The goal is to introduce the concept of the role of microflora on phenotypes and in translational research using GEM models.

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Section: Bacterial Agentsmentioning

confidence: 99%

“…Although S. aureus abscesses are apparently common in SCID mice in the research setting, reports of this disease are limited. 18,56,98 Staphylococci have a number of ways to avoid immune defenses. Some of the organisms may be resistant to eradication in neutrophils through charge neutralization of their anionic cell surfaces.…”

Section: Bacterial Agentsmentioning

confidence: 99%

Of Mice and Microflora

et al. 2011

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“…Among them, Pasteurella pneumotropica in rodents, mainly mice and rats, and Pasteurella multocida in rabbits cause significant clinical or latent infections (Manning et al 1989). P. pneumotropica is an opportunistic pathogen for rodents (Manning et al 1989, Aiello 1998, Jacoby et al 2002. Therefore, the organism has weak pathogenicity and exists in a subclinical carrier state in rodent colonies.…”

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confidence: 99%

Ultrastructural characteristics of the external surfaces of Pasteurella pneumotropica from mice and Pasteurella multocida from rabbits

et al. 2007

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SummaryThe surface structures of the cells of Pasteurella pneumotropica from mice and Pasteurella multocida from rabbits were examined by transmission electron microscopy after ruthenium red staining and polycationic ferritin labelling. P. pneumotropica strains ATCC 35149 and K 79114 had slight extracellular fibrous materials associated with cell walls with ruthenium red staining. Ferritin labelling method revealed thick strands or sparsely ferritinlabelled materials on the cell surface of the strains. P. multocida strains Pm-78 and P-2440 had ferritin-labelled capsules surrounded with the cell wall. Strain Pm-78, which was serotyped as A:12, had a thick capsule, whereas serotype À:3 strain P-2440 had a thin and irregular capsule.

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“…15,16 Additionally, in the absence of susceptible neonates the virus has no chance to spread or even survive. 14 However, the breeding suspension is thought to fail in colonies of immunodeficient or transgenic mice since those animals often shed virus for extended periods. 17 Therefore, it was questionable as to whether this approach would be suitable for sanitizing a rotavirus infection in current experimental mouse colonies comprising a huge variety of transgenic mice with partially unknown immune status.…”

mentioning

confidence: 99%

“…13,14 This method provides the opportunity to build up immunity in adult mice and has been successfully applied to eradicate murine coronaviruses. 15,16 Additionally, in the absence of susceptible neonates the virus has no chance to spread or even survive.…”

mentioning

confidence: 99%

Successful sanitation of an EDIM-infected mouse colony by breeding cessation

2011

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Despite decreasing prevalence, rotavirus infections still rank among the most important viral infections in colonies of laboratory mice. Although the disease is characterized by low mortality and a relatively short and mild clinical period, the infection has the potential to alter the outcome of experiments substantially. For animal facilities, it is therefore essential to eradicate the virus. Here we report a successful sanitation of a rotavirus-infected mouse colony in an animal facility. Despite a high ratio of transgenic and partially immunodeficient strains, a permanent eradication of the virus was achieved by euthanasia of highly susceptible mice, a prolonged breeding cessation in areas containing immunocompromised mice and a strict hygienic management. The management of a rotavirus infection reported here is a feasible and inexpensive opportunity for sanitation that benefits from maintaining most of the animal population, even in today's mouse colonies comprising mainly transgenic mice with unknown or compromised immune status.

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Biology and Diseases of Mice

Cited by 51 publications

References 157 publications

Of Mice and Microflora

Of Mice and Microflora

Ultrastructural characteristics of the external surfaces of Pasteurella pneumotropica from mice and Pasteurella multocida from rabbits

Successful sanitation of an EDIM-infected mouse colony by breeding cessation

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