Biologische Wirkungen des Phaeantharinchlorids und einiger Synthesezwischenprodukte

Knabe, J.; Baldauf, J.; Hanke, B.

doi:10.1002/ardp.19883210111

Cited by 15 publications

(17 citation statements)

References 8 publications

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“…1 The chemistry and property of hydantoin and its derivatives have been investigated for more than 140 years. These studies indicate that hydantoin and its derivatives have a broad range of biological activities including anticonvulsants, 2 antiarithmics, 3 antitumor, 4 antidepressants, 5 and antiviral agents. 6 Phenytoin 1 (5,5-diphenylhydantoin, DPH) is one of the best known derivatives of hydantoin.…”

Section: Introductionmentioning

confidence: 94%

Solvent-free highly regioselective Michael addition of phenytoin to α,β-unsaturated esters in the presence of TBAB under ultrasound irradiation

Imanzadeh¹,

Rezaee-Gatar²

2015

Arkivoc

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The highly regioselective C-N bond formation between phenytoin and acrylic/fumaric esters was accomplished. Solvent-free media Michael addition of phenytoin to acrylic esters led to the selective synthesis of N3-substituted phenytoins (as mono-Michael adducts) in the presence of tetrabutylammonium bromide (TBAB) and potassium carbonate under ultrasonic irradiation conditions at room temperature. These reactions produced N1,N3-disubstituted phenytoins (as bis-Michael adducts) at 70 ºC. Surprisingly, the addition of phenytoin to fumaric esters, instead of acrylic esters, selectively provided only N3-substituted phenytoins at both room temperature and 70 ºC under the same conditions.

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Section: Introductionmentioning

confidence: 94%

Solvent-free highly regioselective Michael addition of phenytoin to α,β-unsaturated esters in the presence of TBAB under ultrasound irradiation

Imanzadeh¹,

Rezaee-Gatar²

2015

Arkivoc

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“…[1][2][3][4][5]. Thiohydantoins find important applications as medicinal (anticonvulsant drugs in the treatment of epilepsy [6,7], antiarrhythmic [8,9], antitumor [10] and anticancer [11] drugs), as agrochemicals (bactericides and ISSN: 2320-5407 Int. J. Adv.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Use of 2-(1-(4-Bromophenyl) Ethylidene)hydrazinecarbothioamide and 2-(5-Chloro-2-Oxoindolin-3-Ylidene)hydrazinecarbothioamide in the Syntheses of 2-Thiohydantoin, Pyrimidine Derivatives: Evaluation of Their Antimicrobial Activities.

El-Hady¹,

nathali²,

Sayed³

2017

IJAR

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“…Due to their diverse biological and pharmacological properties, these compounds have been used in a wide variety of applications [1]. For instance, hydantoins have been widely used as antiarrhythmic and antihypertensive [2,3], antiviral [4], antineoplastic [5], antitumoral [6] and anticonvulsant agents [7,8]. Thiohydantoins are known for their uses as hypolipidemic [9], antimutagenic [10] and anticarcinogenic agents [11].…”

Section: Introductionmentioning

confidence: 99%

Crystal structures of racemic and enantiomeric 5-isopropyl-5-methylhydantoin

et al. 2014

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KEYWORDSCrystal structures of racemic and enantiomeric 5-isopropyl-5-methylhydantoin (IPrMH) have been determined by single crystal X-ray diffraction. Melting temperatures and solid state infrared spectra are also measured. Racemic IPrMH has a lower melting temperature than the pure enantiomer by 25 °C. The infrared spectrum of racemic IPrMH is identical with that of the pure enantiomer. Nevertheless, the racemic IPrMH doesn't crystallize as a conglomerate but as a racemic compound. The racemic and the enantiomeric crystals are very similar to each other in molecular geometries and intermolecular interactions. In the both cases, the molecules are connected via N−H···O hydrogen bonds to form R 2 2(8) rings, and these rings are linked into infinite one-dimensional tapes. In the racemic crystal, a single tape is composed of single enantiomer and itself is homochiral. Hydantoin Enantiomer Conglomerate Crystal structure Racemic compound Imidazolidine-2,4-dione

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Biologische Wirkungen des Phaeantharinchlorids und einiger Synthesezwischenprodukte

Cited by 15 publications

References 8 publications

Solvent-free highly regioselective Michael addition of phenytoin to α,β-unsaturated esters in the presence of TBAB under ultrasound irradiation

Solvent-free highly regioselective Michael addition of phenytoin to α,β-unsaturated esters in the presence of TBAB under ultrasound irradiation

Use of 2-(1-(4-Bromophenyl) Ethylidene)hydrazinecarbothioamide and 2-(5-Chloro-2-Oxoindolin-3-Ylidene)hydrazinecarbothioamide in the Syntheses of 2-Thiohydantoin, Pyrimidine Derivatives: Evaluation of Their Antimicrobial Activities.

Crystal structures of racemic and enantiomeric 5-isopropyl-5-methylhydantoin

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