Biologische Grundlagen der Strahlentherapie

Streffer, C.

doi:10.1007/978-3-642-96346-9_5

Cited by 2 publications

(2 citation statements)

References 84 publications

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“…given the number of fractions n, the fraction size of d, an a/b ratio of 10 Gy for acute skin reactions (29), a time factor c/a of 0.7 Gy/d, the overall treatment time of T, and a starting time for compensatory proliferation T 0 of 21 days (30).…”

Section: Methodsmentioning

confidence: 99%

Association between Polymorphisms in the DNA Repair Genes, XRCC1, APE1, and XPD and Acute Side Effects of Radiotherapy in Breast Cancer Patients

Chang‐Claude

Popanda

Tan

et al. 2005

Clinical Cancer Research

165

101

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Purpose: Several DNA repair gene polymorphisms have been described, which affect DNA repair capacity and modulate cancer susceptibility.We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg Asn), with the risk of acute skin reactions following radiotherapy. Design: We conducted a prospective study of 446 female patients with breast cancer who received radiotherapy after breast-conserving surgery. Individual genetic polymorphisms were determined using melting point analysis of sequence-specific hybridization probes. The development of acute skin reactions (moist desquamation) associated with DNA repair gene polymorphisms was modeled using Cox proportional hazards, accounting for cumulative biologically effective radiation dose. Results: Overall, the development of acute toxicity, which presented in 77 patients, was not associated with the genetic variants studied, although the hazard ratios (HR) were generally below 1. Risks were however differential by body mass index. Among normal-weight patients only, both carriers of the APE1 148Glu and the XRCC1 399Gln alleles had decreased risk of acute skin reactions after radiotherapy (HR, 0.49 and 0.51, respectively). The results for XRCC1 were confirmed by haplotype analysis. When considering joint effects, we observed that compared with homozygote carriers of the wild-type allele in both genes, the risk was most strongly reduced in carriers of both APE1148 Glu and XRCC1 399 Gln alleles with normal weight [HR, 0.19; 95% confidence interval (95% CI), 0.06-0.56] but not in those with overweight (HR, 1.39; 95% CI, 0.56-3.45; P interaction = 0.009). Conclusion: The XRCC1399 Gln or APE1 148

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Section: Methodsmentioning

confidence: 99%

Association between Polymorphisms in the DNA Repair Genes, XRCC1, APE1, and XPD and Acute Side Effects of Radiotherapy in Breast Cancer Patients

Chang‐Claude

Popanda

Tan

et al. 2005

Clinical Cancer Research

165

101

View full text Add to dashboard Cite

show abstract

“…given the number of fractions n, the fraction size of d, an a/b ratio of 10 Gy for acute skin reactions (17), a time factor c/a of 0.7 Gy daily, the overall treatment time of T, and a starting time for compensatory proliferation T 0 of 21 days (18). Acute toxicities.…”

Section: Measurementsmentioning

confidence: 99%

Polymorphisms in Genes Related to Oxidative Stress (CAT, MnSOD, MPO, andeNOS) and Acute Toxicities from Radiation Therapy following Lumpectomy for Breast Cancer

Ahn

Ambrosone

Kanetsky

et al. 2006

Clinical Cancer Research

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Purpose: Because radiotherapy exerts cytotoxic effects via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase (MPO), and endothelial nitric oxide synthase (eNOS) genotypes might result in greater risk of radiotoxicity. Experimental Design: Cases (n = 446) were Caucasian women with breast cancer who received radiotherapy following lumpectomy. Genotypes were determined by matrix-assisted laser desorption/ionization time-of-flight. The development of acute reactions (moist desquamation) associated with genotypes was modeled using the Cox proportional hazards model, accounting for cumulative biologically effective radiation dose. Results: Genotypes associated with higher levels of reactive oxygen species (ROS) were not associated with risk of radiotoxicity. However, relationships between overweight/obesity [body mass index (BMI), >25] and radiotoxicity risk seemed to be modified by eNOS and MPO genotypes associated with higher generation of nitric oxide and ROS, respectively. Women with high BMI (>25) and eNOS GG genotypes were at more than a 6-fold increase in risk (hazard ratio, 6.39; 95% confidence interval, 2.53-16.15) compared with those with BMI <25, and for MPO, those with high BMI (>25) and GG genotypes also had greater risk of radiotoxicity (hazard ratio, 3.61; 95% confidence interval, 1.78-7.35) compared with those with BMI <25. Overweight/obesity was not a strong risk factor among women with other eNOS and MPO genotypes. Exploratory analysis using classification and regression trees indicated that total number of risk alleles contributed, in part, to acute toxicity outcomes among a subgroup of women. Conclusions: Associations between BMI and radiotoxicity risk may be most apparent among women with genotypes related to higher levels of oxidative stress. Regression trees may be useful in future studies to examine the contributions of multiple factors to individual susceptibility to adverse effects of cancer treatment.

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Biologische Grundlagen der Strahlentherapie

Cited by 2 publications

References 84 publications

Association between Polymorphisms in the DNA Repair Genes, XRCC1, APE1, and XPD and Acute Side Effects of Radiotherapy in Breast Cancer Patients

Association between Polymorphisms in the DNA Repair Genes, XRCC1, APE1, and XPD and Acute Side Effects of Radiotherapy in Breast Cancer Patients

Polymorphisms in Genes Related to Oxidative Stress (CAT, MnSOD, MPO, andeNOS) and Acute Toxicities from Radiation Therapy following Lumpectomy for Breast Cancer

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