Biologische Effekte von Bariumsulfat als R�ntgenkontrastmittelbeimengung in Knochenzementen

Abstract

The investigations presented in this paper concern the question of toxicity of Bariumsulfate as an ingredient of bone-cement. In 6 rabbits the medullary cavity of the right femur was filled with bone-cement which contained Bariumsulfate as X-ray contrast ingredient and the left one with BaSO4-free bone-cement. 4 1/2 months post operationem the femura were investigated by histological and microradiographic methods. The status of both sides was compared. On the BaSO4-containing side regularly necrotic lamellar bone structures in the zones of osteogenesis and single disseminated necroses are found which are not caused by the primary lesion occuring during the implantation procedure. Additionally the zone of primary lesions which is found on both sides was more extensive at the BaSO4-containing side.

Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent

“…To realize the multifunction, further surface modification of this porous BaSO 4 microparticle is carried out. In this study, PDA coating is used as a platform for modification, which is an easy method for surface modification, is not only applied to modify most materials but also forms functional groups for further reaction [17,20,21,22]. EDS result shows that Ag and I-CD are modified on the surface of porous BaSO 4 microparticles with the help of PDA coating.…”

“…Silver-based nanomaterials are known for their strong antibacterial activities for a lot of bacteria [17,21,22]. Previous studies indicated the presence of catechol structure in polydopamine could inhibit the growth and proliferation of bacteria in some extent.…”

“…Micro/nano-sized BaSO 4 particles have high specific surface area, and which may be benefit for improving its biocompatibility and optical imaging property [16]. In recent years, porous materials have been widely used in the field of catalysis, adsorption, and drug delivery due to their large specific surface area, tailored pore size, structure and surface properties [17]. With the purpose to further increase the specific surface area of BaSO 4 particles to enhance biocompatibility and realize multifunction, porous BaSO 4 particles are raised [11,16].…”

“…The antibacterial property of BaSO 4 particles could be realized by PDA-assisted Ag deposition. Ag modification is a useful method to inhibit bacterial infection [17,21,22,23]. Inflammation caused by bacteria is common in patients after surgeries.…”

“…The therapeutic effect of BaSO 4 particles as radiopaque agent could be endowed with loading therapeutic drugs by porous structure, PDA coating and cyclodextrin (CD). The porous BaSO 4 particles can load drugs [17]. PDA modification may also promote protein adsorption on the surface of particles [20].…”