Biologika und „small molecules“ bei der rheumatoiden Arthritis

Blüml, Stephan

doi:10.1007/s00393-020-00766-7

Cited by 8 publications

(6 citation statements)

References 75 publications

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“… 20 Rheumatologists now have a large variety of highly efficient drugs with different mechanisms of action in which the molecular target of the drug is known, which is not the case for csDMARDs. 21 …”

Section: Discussionmentioning

confidence: 99%

“…The interaction between cytokines and their signaling pathways are the basis for the development of new strategies with small molecules or bispecific antibodies 20 . Rheumatologists now have a large variety of highly efficient drugs with different mechanisms of action in which the molecular target of the drug is known, which is not the case for csDMARDs 21 …”

Section: Discussionmentioning

confidence: 99%

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Going Further: Comprehensive Disease Control of Rheumatoid Arthritis, Targeting Cytokines and Chemokines

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Going Further: Comprehensive Disease Control of Rheumatoid Arthritis, Targeting Cytokines and Chemokines

et al. 2020

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“…Often, the disorder cannot be cured and thus requires life-long therapy (3,4). Hence, there is a huge demand for cost-effective and safe additive therapies, as lifelong medication is not only expensive, but also comes along with a marked risk of adverse effects (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders– results from a prospective, randomized, placebo-controlled trial

Donaubauer,

Becker,

Klein

et al. 2024

Front. Immunol.

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In this randomized, placebo-controlled cross-over trial we aimed to investigate if radon spa therapy exerts more pain relief than exposure to warm water alone. In addition, immunological parameters were assessed in both treatment groups. In the RAD-ON02 trial, 116 patients suffering from musculoskeletal disorders (MSDs) received either serial radon spa or solely warm water baths. Pain intensity was assessed by determination of different pain parameters on a visual analogue scale and by pressure point dolorimetry at baseline and at weeks 4, 12 and 24. The longitudinal immune status of the patients was analyzed by a flow cytometry-based assay from peripheral blood at the time points of pain assessments. There were no side effects attributable to radon exposure observed. However, radon spa was superior to warm water applications at week 4 in terms of pain reduction. Pain and morning stiffness at the time of assessment were significantly reduced after radon spa (p<0.001, p<0.01) but not after warm water baths. The dolorimetry resulted in a significantly higher exerted pressure strength in patients after radon spa (p<0.001), but not after warm water applications. During the long-term follow-up, both treatment modalities reduced pain to a similar degree and pain modulation was not distorted by the participants’ intake of analgesics. No significant changes in the immune status attributable specifically to radon were found, even though the increase in regulatory T cell counts occurs earlier after radon baths than after sole warm water baths and a higher level of significance is reached after radon spa at week 24. Serial radon spa has additive pain-relieving effects. The immunological parameters assessed in our study appear not to be directly linked to the pain reduction caused by radon exposure, at least in MSD patients with predominantly degenerative diseases.Clinical trial registrationhttps://www.clinicaltrialsregister.eu/ctr-search/search?query=rad-on02, identifier 2016-002085-31; https://drks.de/search/de/trial, identifier DRKS00016019.

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“…Environmental and genetic factors are reported to associate with disease pathogenesis. In recent years, much progress has been made for treatment of RA, for instance, a number of specific drugs have been developed and used for medical treatment 3 . However, effects of the medicines on RA patients still need to be discussed and adverse effects cannot be neglected.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis

Zhou

et al. 2021

Int J of Rheum Dis

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Aim Previous studies have shown that silent information regulator 1 (SIRT1) expression is elevated in rheumatoid arthritis (RA) patients. However, whether gene polymorphisms in SIRT1 gene associated with RA in a Chinese Han population remains to be discussed. Method In this case‐control study, 529 RA patients and 700 healthy controls were selected, and association of 11 SIRT1 gene polymorphisms (rs12415800, rs3740051, rs932658, rs3740053, rs7895833, rs10509291, rs33957861, rs7069102, rs2273773, rs3818292, rs1467568) with RA susceptibility was evaluated. Results Frequency of GA+GG genotype of rs3740051 in RA patients was significantly lower than that in healthy controls (P = .037). Frequencies of GC and GC+GG genotypes of rs7069102 were significantly lower than those in healthy controls (P = .036, P = .047). Frequencies of GA and GA+GG genotypes of rs1467568 were lower in RA patients as compared to those in healthy controls (P = .011, P = .013). For rs2273773, RA patients who carried the T allele had higher number of tender joints than patients who carried the C allele (P = .033). Other polymorphisms did not associate with RA risk. Conclusion The findings suggest that rs3740051, rs7069102 and rs1467568 variants in SIRT1 gene are related to RA susceptibility in a Chinese Han population.

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Biologika und „small molecules“ bei der rheumatoiden Arthritis

Cited by 8 publications

References 75 publications

Going Further: Comprehensive Disease Control of Rheumatoid Arthritis, Targeting Cytokines and Chemokines

Going Further: Comprehensive Disease Control of Rheumatoid Arthritis, Targeting Cytokines and Chemokines

Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders– results from a prospective, randomized, placebo-controlled trial

Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis

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