Biologiczne aspekty śródoperacyjnej radioterapii i roli płynów pooperacyjnych w terapii raka piersi

Piotrowski, Igor; Kulcenty, Katarzyna; Murawa, Dawid; Suchorska, Wiktoria Maria

doi:10.21641/los.13.2.13

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…Zależnie od stopnia zaawansowania dobierany jest odpowiedni schemat leczenia oraz szacowane jest rokowanie chorej [16].…”

Section: Natalia Wypij / Zeszyty Naukowe Wco Letters In Oncology Sciunclassified

Obrazowanie raka piersi za pomocą rezonansu magnetycznego- wskazania

Wypij¹

2017

LOS

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StreszczenieRak piersi to najczęstszy nowotwór występujący wśród kobiet . W nowotworze sutka ważną rolę odgrywa diagnostyka obrazowa. Jej głównym celem jest jak najwcześniejsze wykrycie zmiany a także ocena wielkości i położenia. W obrazowaniu raka piersi wykorzystujemy dwie podstawowe metody, do których zaliczamy mammografię i usg oraz metodę dodatkową, tj. rezonans magnetyczny (MRI). MRI cechuje się najwyższą czułością w wykrywaniu niewielkich zmian. Jednak metoda ta nie powszechnie stosowana wśród wszystkich pacjentek. Istnieje szereg wskazań do wykonania tego badania. Część z nich zostanie omówiona w pracy. AbstractBreast cancer is the most commonly occurring tumor in women. In breast cancer diagnostic imaging plays an important role. The main purpose of imaging is to detect the change in breast at the earliest stage and to evaluate the size and location of the lesion. Mammography and Ultrasound are the primary imaging modalities used for breast cancer. Magnetic Resonance Imaging is an additional examination. MRI provides superior sensitivity to detect small changes in breast, but is not used in all patients. There are a number of indications for performing this study. Some of them will be discussed in this work.

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“…Zależnie od stopnia zaawansowania dobierany jest odpowiedni schemat leczenia oraz szacowane jest rokowanie chorej [16].…”

Section: Natalia Wypij / Zeszyty Naukowe Wco Letters In Oncology Sciunclassified

Obrazowanie raka piersi za pomocą rezonansu magnetycznego- wskazania

Wypij¹

2017

LOS

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“…Unfortunately, these therapies have low tumor sensitivity and higher toxicity, which reduces overall therapy effectiveness. The interplay of inflammation in colon cancer is well-established by many epigenetic and pharmacological analyses [5]. Inflammatory cytokines promote tumor cell growth, interrupt differentiation, and aid in cancer cell survival [6].…”

Section: Introductionmentioning

confidence: 99%

An in-Depth Study on the Anti-Oxidant and Anti-Apoptotic Potentials of Quercetin in Human Colon Cancer Cell Lines

Bhatiya¹,

Jain²,

Das³

et al. 2023

Preprint

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(1) Background: Colon cancer is one of the leading causes of cancer morbidity and mortality globally. It is a multi-step process that involves genetic and epigenetic modifications leading to histological and morphological changes. Several complementary therapeutic options have been analyzed, shedding light on plant-based medication as a potential treatment for colon cancer. Flavonoids such as quercetin are known to have anti-cancer and anti-inflammatory properties. This in vitro study examines quercetin's anti-inflammatory, anti-apoptotic, anti-angiogenesis effects and antioxidant properties in colon cancer cells. (2) Methods: The antioxidant capacity of quercetin-treated cells was investigated using biochemical assays, and angiogenesis and cytokine levels were assessed using enzyme-linked immunosorbent assay (ELISA). The epigenetic modulation and differential expression of aging, apoptotic, and proliferation genes, and Histone deacetylases (HDACs) were also investigated. (3) Results: In this study, the quercetin-treated group significantly reduced the antioxidant enzymes, cytokines, and VEGF levels, altering the expression of epigenetic factors. Quercetin also induced significant senescence in colon cancer cells. Moreover, a considerable increase was observed in the apoptotic and hTERT genes. In contrast, a decrease in p53, proliferation genes, and HDACs was observed, providing a basis for the clinical use of quercetin in cancer treatment. (4) Conclusion: In vitro studies showed that quercetin treatment efficiently induces senescence and apoptosis in colon cancer cells. We also found that quercetin effectively modulated the expression of p53, Wnt1, CTNNB1, and HDACs, indicating that it could be used to treat colon cancer.

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“…Intraoperative radiotherapy is performed immediately after surgical removal of the tumour to eradicate any remaining cancer cells located in or around the tumour bed [ 4 , 5 ]. The electrons are produced by a mobile accelerator unit.…”

Section: Introductionmentioning

confidence: 99%

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

Dróżdż

Waluś

Zieliński

et al. 2021

Rep Pract Oncol Radiother.

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Background The availability of linear accelerators (linac) for research purposes is often limited and therefore alternative radiation sources are needed to conduct radiobiological research. The National Centre for Radiation Research in Poland recently developed an intraoperative mobile linac that enables electron irradiation at energies ranging from 4 to 12 MeV and dose rates of 5 or 10 Gy/min. The present study was conducted to evaluate the electron beam parameters of this intraoperative linac and to verify the set-up to evaluate out-of-field doses in a water phantom, which were determined through dosimetric and biological response measurements. Materials and methods The distribution of radiation doses along and across the radiation beam were measured in a water phantom using a semiconductor detector and absolute doses using an ionisation chamber. Two luminal breast cancer cell lines (T-47D and HER2 positive SK-BR-3) were placed in the phantom to study radiation response at doses ranging from 2 to 10 Gy. Cell response was measured by clonogenic assays. Results and Conclusion The electron beam properties, including depth doses and profiles, were within expected range for the stated energies. These results confirm the viability of this device and set-up as a source of megavoltage electrons to evaluate the radiobiological response of tumour cells.

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Biologiczne aspekty śródoperacyjnej radioterapii i roli płynów pooperacyjnych w terapii raka piersi

Cited by 3 publications

References 44 publications

Obrazowanie raka piersi za pomocą rezonansu magnetycznego- wskazania

Obrazowanie raka piersi za pomocą rezonansu magnetycznego- wskazania

An in-Depth Study on the Anti-Oxidant and Anti-Apoptotic Potentials of Quercetin in Human Colon Cancer Cell Lines

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

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