Biologics in rotator cuff surgery

Schär, Michael; Rodeo, Scott A.; Zumstein, Matthias A.

doi:10.1177/1758573214536536

Cited by 7 publications

(3 citation statements)

References 26 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…¶ This increase in included studies allowed for sufficient numbers to be subgrouped into PRP and PRF, as no other meta-analysis had done this. This increase in numbers also allowed for sufficient power to detect a difference in larger tears, as previous studies had found a significant difference in tears <3 cm 6,40,49 but for tears >3 cm, because they were limited by the lack of numbers to detect a difference. Previous studies have not identified a difference in functional outcomes when using PRP.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Arthroscopic Rotator Cuff Repair: A Meta-analysis of Randomized Controlled Trials

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Arthroscopic Rotator Cuff Repair: A Meta-analysis of Randomized Controlled Trials

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There is continued interest in biologic therapies to improve tendon to bone healing in rotator cuff repairs [2,6,29,31]. The cell-based therapy using progenitor cells is a promising strategy for regeneration and healing of the tendon tissues [1, 6, 10, 11, 19, 23, 24, 26-28, 30, 36, 37].…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction

Virk

Luo

Sikes

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Rotator cuff tendon tears are typically degenerative and usually affect the region of tendon insertion on bone. The remnant torn tendon is degenerative and may not be an ideal source for progenitor cells for cellbased therapies. Therefore, the aim of this study was to determine if musculotendinous junction (MTJ), which is adjacent to tendon would be a viable alternate source of progenitor stem cells. We also sought to study the gene expression profile MTJ progenitors and compare it with progenitors isolated from RC tendon, RC muscle and other existing tissue sources (bone marrow, adipose tissue, and Achilles tendon). Methods: Rotator cuff tendon (RCT), muscle (RCM), and RCMTJ as well as Achilles tendon (AT) tissues were harvested from healthy male Lewis rats and progenitor cultures were established from these tissues and also from bone marrow and adipose tissue. Quantitative RT-PCR was performed on RNA extracts from intact tissues and progenitor cells using a custom array for the mesenchymal stem cell (MSC) differentiation marker genes. The gene expression profile of MSC differentiation markers within four tissues types, six progenitor cells, and between tissue and their corresponding progenitors were compared.Results: Progenitors cells can be isolated from rat rotator cuff musculotendinous tissue and their pattern of MSC gene expression was similar to the rotator cuff tendon progenitors for majority of the genes tested. However, there were significant differences between the MSC gene expression patterns of RCMTJ and RCM progenitors. Furthermore, there were differences in gene expression between the RCMTJ tissue and its progenitor cells with respect to MSC differentiation markers. The gene expression pattern of RCMTJ tissue was similar to RCM tissue with respect to markers of chondrogenesis, myogenesis, tenogenesis, and MSC specific markers. Conclusion:We demonstrate that the musculotendinous junction contains distinct set of progenitor cells and their MSC gene expression pattern is similar to rotator cuff tendon progenitors. RCMTJ progenitors will be an attractive option for cell-based regenerative treatment of chronic rotator cuff tears.

show abstract

“… 14 , 43 Because of the inconsistent healing despite significant improvements in mechanical fixation, biological strategies to augment the surgical repair, including bioresorbable scaffolds, have been introduced in an effort to improve the rate of tendon healing. 39 …”

mentioning

confidence: 99%

Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep

Romeo

Easley

Regan

et al. 2022

Journal of Shoulder and Elbow Surgery

View full text Add to dashboard Cite

Background: The purpose of this study was to evaluate the mechanical, structural, and histologic quality of rotator cuff repairs augmented with an interposition electrospun nanofiber scaffold composed of polyglycolic acid (PGA) and poly-L-lactide-co-ε-caprolactone (PLCL) in an acute sheep model. Methods: Forty acute infraspinatus tendon detachment and repair procedures were performed in a sheep infraspinatus model using a double-row transosseous-equivalent anchor technique either with an interposition nanofiber scaffold composed of polyglycolic acid-poly-L-lactide-co-ε-caprolactone or with no scaffold. Animals were euthanized at the 6-week (20 samples) and 12-week (20 samples) postoperative time points to assess the biomechanical and histologic properties of the repairs and to compare differences within each group. Results: Within the scaffold-treated group, there was a significant increase in ultimate failure force (in newtons) from 6 to 12 weeks (P < .01), a significant increase in ultimate failure load from 6 to 12 weeks (P < .01), and a significant increase in ultimate failure stress (in megapascals) from 6 to 12 weeks (P < .01). At 6 weeks, the tendon-bone attachment was most consistent with an ''indirect'' type of insertion, whereas at 12 weeks, a visible difference in the progression and re-formation of the enthesis was observed. Compared with controls, animals in the scaffold-treated group displayed an insertion of the fibrous tendon with the humeral footprint that was beginning to be organized in a manner similar to the ''native'' direct/fibrocartilaginous insertion of the ovine infraspinatus tendon. In the majority of these animals treated with the scaffold, prominent perforating collagen fibers, similar to Sharpey fibers, were present and extending through a region of calcified fibrocartilage and attaching to the humeral footprint. No surgical complications occurred in any of the 40 sheep, including delayed wound healing or infection. Conclusions: In a sheep acute rotator cuff repair model, securing a nanofiber scaffold between the tendon and the bone using a doublerow transosseous-equivalent anchor fixation technique resulted in greater failure strength. Additionally, at the enthesis, Sharpey fiber-like attachments (ie, collagen fibers extending from the tendon into the calcified fibrocartilage of the humerus) were observed, which were not seen in the control group.Institutional review board approval was not required for this basic science study. This study was conducted under Institutional Animal Care and Use Committee approval by board-certified veterinary surgeons (Colorado State University no. 17-7154).

show abstract

Biologics in rotator cuff surgery

Cited by 7 publications

References 26 publications

The Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Arthroscopic Rotator Cuff Repair: A Meta-analysis of Randomized Controlled Trials

The Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Arthroscopic Rotator Cuff Repair: A Meta-analysis of Randomized Controlled Trials

Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction

Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep

Contact Info

Product

Resources

About