Biologics in nail psoriasis: a new trend in treatment?

Rigopoulos, Dimitrios

doi:10.1111/jdv.15988

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Psoriasis is generally characterized by hyperproliferation, [ 30 ] and miR‐215 could effectively suppress cell proliferation in various diseases. [ 9,31,32 ] Consistent with previous studies, overexpression of miR‐215‐5p suppressed the proliferation and cell cycle progression of HaCaT, a type of keratinocytes, which was a key event in the development of chronic inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐215‐5p inhibits the proliferation of keratinocytes and alleviates psoriasis‐like inflammation by negatively regulating DYRK1A and its downstream signalling pathways

Liu

Zhang

Zhao

et al. 2020

Experimental Dermatology

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Psoriasis is a chronic inflammatory disease characterized by abnormal hyperproliferation and differentiation. The object of this study is to explore the role of microRNA‐215‐5p in psoriasis‐like inflammation. The expression of miR‐215‐5p was found to be down‐regulated in pro‐inflammatory factor‐stimulated HaCaT cells and imiquimod (IMQ)‐treated skin tissues. Overexpression of miR‐215‐5p suppressed the proliferation and cell cycle progression of HaCaT cells. Further, miR‐215‐5p agomir alleviated the disease severity, pathological features and Ki67 positive cells in IMQ‐treated mice. Luciferase assay confirmed that miR‐215‐5p could bind to the 3′UTR of DYRK1A. The in vitro and in vivo results showed that miR‐215‐5p negatively regulates DYRK1A, which further inhibited EGFR and its downstream signalling pathways, AKT and ERK. Collectively, our results provide evidence that overexpression of miR‐215‐5p inhibits the proliferation of HaCaT cells and alleviates psoriasis‐like inflammation partly by DYRK1A mediated inhibition of the EGFR signalling pathway. miR‐215‐5p may serve as a novel small molecule for therapeutic intervention in psoriasis.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‐215‐5p inhibits the proliferation of keratinocytes and alleviates psoriasis‐like inflammation by negatively regulating DYRK1A and its downstream signalling pathways

Liu

Zhang

Zhao

et al. 2020

Experimental Dermatology

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Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis

Perrin

2020

The American Journal of Dermatopathology

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To determine whether distal interphalangeal joint psoriatic arthritis (DIP PsA) and nail psoriasis are anatomically linked, we studied 2 fingers taken from a cadaver presenting a typical cutaneous and nail psoriasis in the setting of a dactylitis limited to the fourth toe. This comprehensive study of the inflammatory pattern of DIP PsA is discussed in the context of the controversial theory of the nail as a musculoskeletal appendage. Both the extensor and flexor entheses were focally and quite markedly infiltrated by lymphocytes and showed variable fibrosis and neovascularization. In addition, some clusters of giant cells were seen. Synovial perivascular inflammation was focally relatively dense. Discrete periostitis and bone inflammation of the intertrabecular spaces were seen, maximally at the insertion of the extensor and flexor tendons. The retained superficial fibrocartilaginous and tendinous cuff separated the inflamed extensor enthesis from the surrounding connective tissues. The thick proximal periosteum constituted a barrier between the inflamed bone and the matrical hypoderm. The lateral sections showed inflammation at 3 levels as follows: the enthesis of the interosseous ligament and collateral ligament, periosteum, and nail epithelium. In the 3 specimens, the inflammatory foci involving entheses and nails were prominent and never contiguous. This suggests that DIP PsA is not merely an extensor enthesitis and that the nail unit remains a microanatomical structure independent from the extensor enthesis, even with severe DIP PsA.

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Biologics in nail psoriasis: a new trend in treatment?

Abstract: Linked article: B.E. Elewski et al. J Eur Acad Dermatol Venereol 2019; 33: 2168–2178. https://doi.org/10.1111/jdv.15793.

Cited by 2 publications

References 4 publications

MicroRNA‐215‐5p inhibits the proliferation of keratinocytes and alleviates psoriasis‐like inflammation by negatively regulating DYRK1A and its downstream signalling pathways

MicroRNA‐215‐5p inhibits the proliferation of keratinocytes and alleviates psoriasis‐like inflammation by negatively regulating DYRK1A and its downstream signalling pathways

Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis

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